{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T07:02:41Z","timestamp":1779692561648,"version":"3.53.1"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Direct-acting antivirals (DAAs) have dramatically changed hepatitis C virus (HCV) treatment, by achieving high virological cure rates and a reduced percentage of adverse events compared with previous treatments. Despite this, long-term psychiatric and quality-of-life (QoL) outcomes after viral eradication remain insufficiently understood. This study provides an 80-month follow-up of a previously evaluated cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Of the original 62 patients, 24 (38.7%) were reassessed approximately 80 months after DAA initiation. Psychopathological symptoms (HAM-D, HAM-A, SCL-90-R), coping strategies (COPE), and QoL (SF-36) were evaluated and compared with baseline (T0). Patients were stratified by psychiatric history (Group P vs. Group NP). Non-parametric tests and exploratory correlations and regressions were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In Group P, depressive and anxiety symptoms significantly improved from T0 to follow-up (HAM-D: 16 vs. 3, p &amp;lt; 0.01; HAM-A: 15 vs. 4, p &amp;lt; 0.01), with additional reductions in SCL-90-R Interpersonal Sensitivity, Paranoid Ideation, and Psychoticism (all p &amp;lt; 0.05). Group NP showed stable psychological profiles, reflecting the maintenance of improvements already observed at T1, with significant reductions in HAM-D (7 vs. 4, p &amp;lt; 0.01) and HAM-A (8 vs. 4, p &amp;lt; 0.001). Both groups demonstrated a significant decline in SF-36 Physical Component Summary (Group P: p &amp;lt; 0.05; Group NP: p &amp;lt; 0.01). No between-group differences were detected at follow-up. Avoidant coping and psychiatric history were significant negative predictors of long-term anxiety change.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Seven years after HCV eradication, psychological well-being remains stable or improved, while physical QoL declines. DAAs demonstrate sustained long-term psychiatric safety, underscoring the need for integrated medical\u2013psychological follow-up in HCV survivors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyt.2026.1768493","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T06:04:22Z","timestamp":1779689062000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Long-term psychological and functional outcomes after hepatitis C eradication with direct-acting antivirals: an 80-month follow-up study"],"prefix":"10.3389","volume":"17","author":[{"given":"Salvatore","family":"Cipolla","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Campania \u201cLuigi Vanvitelli\u201d","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Catapano","sequence":"additional","affiliation":[{"name":"Department of 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