{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T15:00:02Z","timestamp":1780930802094,"version":"3.54.1"},"reference-count":58,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Motivation drives goal-directed behavior, often requiring individuals to approach rewards while facing potential punishment (i.e., goal-conflict). Premenstrual dysphoric disorder (PMDD) is marked by emotional and cognitive impairments that may affect motivational functioning. While emotional deficits in PMDD are well-known, their impact on motivation under goal-conflict remains unclear. This study examined neurobehavioral indications for motivational deficits in PMDD during naturalistic goal-conflict and their relation to symptom severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty-one women with regular menstrual cycles (28 with PMDD, 23 healthy controls) completed a computer-based approach-avoidance task during fMRI scanning in the luteal phase. The task included high and low goal-conflict (HiGC or LoGC) conditions, where rewards were threatened by punishment. Neural activity in mesostriatal reward-related regions \u2013 the ventral striatum (VS) and ventral tegmental area (VTA) \u2013 was analyzed using general linear models. Symptom severity was assessed using the Premenstrual Tension Syndrome Observer Rating Scale (PMTS-OR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with healthy controls, participants with PMDD were less able to increase approach behavior as conflict decreased, resulting in fewer approach events under LoGC condition, while no group differences were observed under HiGC. Additionally, within the PMDD group, greater symptom severity (depression and anxiety) was associated with lower approach behavior under HiGC conditions. fMRI analyses revealed diminished activation in the VS and VTA under HiGC in the PMDD group, suggesting reduced conflict-related engagement of reward-related circuitry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PMDD is associated with impaired motivational adaptation across conflict levels, reflected in a blunted increase in approach behavior under conditions of lower risk. Diminished conflict-related activity in reward-related mesostriatal regions (VS, VTA) may underlie this deficit. These findings highlight the potential role of mesolimbic circuitry dysfunction in PMDD and point toward reward processing pathways as candidate therapeutic targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>NCT02448836, ClinicalTrials.gov.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyt.2026.1776826","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T14:18:24Z","timestamp":1780928304000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Motivational neurobehavioral abnormalities under a naturalistic goal-conflict task in patients with premenstrual dysphoric disorder"],"prefix":"10.3389","volume":"17","author":[{"given":"Yulia","family":"Lerner","sequence":"first","affiliation":[{"name":"Sagol Brain Institute, Tel Aviv Sourasky University Medical Center","place":["Tel Aviv, Israel"]},{"name":"Gray Faculty of Medical & Health Sciences, Tel Aviv University","place":["Tel Aviv, Israel"]},{"name":"Sagol School of Neuroscience, Tel Aviv University","place":["Tel Aviv, Israel"]},{"name":"Psychiatry Division, Tel Aviv Sourasky University Medical Center","place":["Tel Aviv, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Krasnoshtein","sequence":"additional","affiliation":[{"name":"Gray Faculty of Medical & Health Sciences, Tel Aviv University","place":["Tel Aviv, Israel"]},{"name":"Psychiatry Division, Tel Aviv Sourasky University Medical Center","place":["Tel Aviv, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Bloch","sequence":"additional","affiliation":[{"name":"Gray Faculty of Medical & Health Sciences, Tel Aviv University","place":["Tel Aviv, Israel"]},{"name":"Psychiatry Division, Tel Aviv Sourasky University Medical Center","place":["Tel Aviv, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Tevet","sequence":"additional","affiliation":[{"name":"Psychiatry Division, Tel Aviv Sourasky University Medical Center","place":["Tel Aviv, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maayan","family":"Doron","sequence":"additional","affiliation":[{"name":"Sagol Brain Institute, Tel Aviv Sourasky University Medical Center","place":["Tel Aviv, Israel"]},{"name":"School of Psychological Sciences, Tel Aviv University","place":["Tel Aviv, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Gonen","sequence":"additional","affiliation":[{"name":"Sagol Brain Institute, Tel Aviv Sourasky University Medical Center","place":["Tel Aviv, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talma","family":"Hendler","sequence":"additional","affiliation":[{"name":"Sagol Brain Institute, Tel Aviv Sourasky University Medical Center","place":["Tel Aviv, Israel"]},{"name":"Gray Faculty of Medical & Health Sciences, Tel Aviv University","place":["Tel Aviv, Israel"]},{"name":"Sagol School of Neuroscience, Tel Aviv University","place":["Tel Aviv, Israel"]},{"name":"Psychiatry Division, Tel Aviv Sourasky University Medical Center","place":["Tel Aviv, Israel"]},{"name":"School of Psychological Sciences, Tel Aviv University","place":["Tel Aviv, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oren","family":"Tene","sequence":"additional","affiliation":[{"name":"Gray Faculty of Medical & Health Sciences, Tel Aviv University","place":["Tel Aviv, Israel"]},{"name":"Psychiatry Division, Tel Aviv Sourasky University Medical Center","place":["Tel Aviv, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.conb.2013.01.017","article-title":"Neuroscience of affect: brain mechanisms of pleasure and displeasure","volume":"23","author":"Berridge","year":"2013","journal-title":"Curr Opin Neurobiol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2014.00124","article-title":"Approach, avoidance, and their conflict: the problem of anchoring","volume":"8","author":"McNaughton","year":"2014","journal-title":"Front Syst Neurosci"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3758\/s13415-014-0295-6","article-title":"The influence of approach-avoidance motivational orientation on conflict adaptation","volume":"14","author":"Hengstler","year":"2014","journal-title":"Cognit Affect Behav Neurosci"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2023.1123733","article-title":"Reward, motivation and brain imaging in human healthy participants - a narrative review","volume":"17","author":"Weinstein","year":"2023","journal-title":"Front Behav Neurosci"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00378","article-title":"Moods as ups and downs of the motivation pendulum: revisiting reinforcement sensitivity theory (RST) in bipolar disorder","volume":"8","author":"Gonen","year":"2014","journal-title":"Front Behav Neurosci"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biopsycho.2017.04.014","article-title":"Striatal dopaminergic modulation of reinforcement learning predicts reward-oriented behavior in daily life","volume":"127","author":"Kasanova","year":"2017","journal-title":"Biol Psychol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2019.00289","article-title":"Predicting ventral striatal activation during reward anticipation from functional connectivity at rest","volume":"13","author":"Mori","year":"2019","journal-title":"Front Hum Neurosci"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091008","article-title":"Overlapping neural systems represent cognitive effort and reward anticipation","volume":"9","author":"Vassena","year":"2014","journal-title":"PloS One"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.67387","article-title":"The role of ventromedial prefrontal cortex in reward valuation and future thinking during intertemporal choice","volume":"10","author":"Ciaramelli","year":"2021","journal-title":"Elife"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcaa196","article-title":"The orbitofrontal cortex: reward, emotion and depression","volume":"2","author":"Rolls","year":"2020","journal-title":"Brain Commun"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2015_376","article-title":"Mechanisms underlying motivational deficits in psychopathology: Similarities and differences in depression and schizophrenia","volume":"27","author":"Barch","year":"2016","journal-title":"Curr Top Behav Neurosci"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.5.904","article-title":"Personality traits and striatal dopamine synthesis capacity in healthy subjects","volume":"160","author":"Laakso","year":"2003","journal-title":"Am J Psychiatry"},{"key":"B13","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.ajog.2017.05.045","article-title":"Premenstrual disorders","volume":"218","author":"Yonkers","year":"2018","journal-title":"Am J Obstet. Gynecol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-021-01010-9","article-title":"Brain reactivity during aggressive response in women with premenstrual dysphoric disorder treated with a selective progesterone receptor modulator","volume":"46","author":"Kaltsouni","year":"2021","journal-title":"Neuropsychopharmacology"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00380","article-title":"Menstrual cycle influence on cognitive function and emotion processing-from a reproductive perspective","volume":"8","author":"Sundstrom Poromaa","year":"2014","journal-title":"Front Neurosci"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/bs.vh.2018.01.016","article-title":"The menstrual cycle influences emotion but has limited effect on cognitive function","volume":"107","author":"Sundstrom-Poromaa","year":"2018","journal-title":"Vitam. Horm"},{"key":"B17","doi-asserted-by":"publisher","first-page":"198","DOI":"10.3390\/brainsci10040198","article-title":"Cognition, the menstrual cycle, and premenstrual disorders: a review","volume":"10","author":"Le","year":"2020","journal-title":"Brain Sci"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.11305","article-title":"Characterizing a psychiatric symptom dimension related to deficits in goal-directed control","volume":"5","author":"Gillan","year":"2016","journal-title":"Elife"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.3390\/brainsci11091199","article-title":"Sex differences in dopamine receptors and relevance to neuropsychiatric disorders","volume":"11","author":"Williams","year":"2021","journal-title":"Brain Sci"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2015_5004","article-title":"Translational assessment of reward and motivational deficits in psychiatric disorders","volume":"28","author":"Der-Avakian","year":"2016","journal-title":"Curr Top Behav Neurosci"},{"key":"B21","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/bcpt.13271","article-title":"Emerging roles of striatal dopamine D2 receptors in motivated behaviour: Implications for psychiatric disorders","volume":"126","author":"Olivetti","year":"2020","journal-title":"Basic. Clin Pharmacol Toxicol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyx056","article-title":"Dopamine system dysregulation in major depressive disorders","volume":"20","author":"Belujon","year":"2017","journal-title":"Int J Neuropsychopharmacol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-020-00532-4","article-title":"Stress and the dopaminergic reward system","volume":"52","author":"Baik","year":"2020","journal-title":"Exp Mol Med"},{"key":"B24","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1093\/cercor\/bhq065","article-title":"Dissociating valuation and saliency signals during decision-making","volume":"21","author":"Litt","year":"2011","journal-title":"Cereb. Cortex"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_00535","article-title":"Dissociating motivation from reward in human striatal activity","volume":"26","author":"Miller","year":"2014","journal-title":"J Cognit Neurosci"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1038\/s41467-017-02080-4","article-title":"Distributed neural representation of saliency controlled value and category during anticipation of rewards and punishments","volume":"8","author":"Zhang","year":"2017","journal-title":"Nat Commun"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1037\/a0018865","article-title":"Conjunctive encoding of movement and reward by ventral tegmental area neurons in the freely navigating rodent","volume":"124","author":"Puryear","year":"2010","journal-title":"Behav Neurosci"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.10.021","article-title":"The mysterious motivational functions of mesolimbic dopamine","volume":"76","author":"Salamone","year":"2012","journal-title":"Neuron"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsw014","article-title":"Human mesostriatal response tracks motivational tendencies under naturalistic goal conflict","volume":"11","author":"Gonen","year":"2016","journal-title":"Soc Cognit Affect Neurosci"},{"key":"B30","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.jbtep.2016.07.002","article-title":"Emotional interference and attentional processing in premenstrual syndrome","volume":"54","author":"Eggert","year":"2017","journal-title":"J Behav Ther Exp Psychiatry"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1007\/s00737-003-0018-4","article-title":"The premenstrual symptoms screening tool (PSST) for clinicians","volume":"6","author":"Steiner","year":"2003","journal-title":"Arch Womens. Ment Health"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1007\/s00737-005-0103-y","article-title":"Daily record of severity of problems (DRSP): reliability and validity","volume":"9","author":"Endicott","year":"2006","journal-title":"Arch Womens. Ment Health"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2011.06.058","article-title":"The premenstrual tension syndrome rating scales: an updated version","volume":"135","author":"Steiner","year":"2011","journal-title":"J Affect Disord"},{"key":"B34","volume-title":"ECDEU assessment manual for psychopharmacology","author":"Guy","year":"1976"},{"key":"B35","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1037\/t03713-000","article-title":"The development of markers for the Big-Five factor structure","volume":"4","author":"Goldberg","year":"1992","journal-title":"Psychol Assess"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.1046","article-title":"Paradigm-dependent modulation of event-related fMRI activity evoked by the oddball task","volume":"14","author":"Clark","year":"2001","journal-title":"Hum Brain Mapp"},{"key":"B37","volume-title":"Co-planar stereotaxic atlas of the human brain: 3-dimensional proportional system: an approach to cerebral imaging","author":"Talairach","year":"1988"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.10.044","article-title":"Recent progress and outstanding issues in motion correction in resting state fMRI","volume":"105","author":"Power","year":"2015","journal-title":"Neuroimage"},{"key":"B39","doi-asserted-by":"publisher","first-page":"116189","DOI":"10.1016\/j.neuroimage.2019.116189","article-title":"Automated anatomical labelling atlas 3","volume":"206","author":"Rolls","year":"2020","journal-title":"NeuroImage"},{"key":"B40","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R. Stat Soc Ser B. Stat Methodol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1013699998","article-title":"The control of the false discovery rate in multiple testing under dependency","volume":"29","author":"Benjamini","year":"2001","journal-title":"Ann Stat"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.05.030","article-title":"fMRI in the presence of task-correlated breathing variations","volume":"47","author":"Birn","year":"2009","journal-title":"Neuroimage"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20345","article-title":"Bias between MNI and Talairach coordinates analyzed using the ICBM-152 brain template","volume":"28","author":"Lancaster","year":"2007","journal-title":"Hum Brain Mapp"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.52294\/001c.87681","article-title":"NiMARE: Neuroimaging meta-analysis research environment","volume":"3","author":"Salo","year":"2023","journal-title":"Aperture Neuro"},{"key":"B45","volume-title":"The neuropsychology of anxiety: An enquiry into the functions of the septo-hippocampal system","author":"Gray","year":"1982"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.00028","article-title":"Reduced reward responsiveness in women with moderate - to - severe premenstrual syndrome: Evidence from a probabilistic reward task","volume":"11","author":"Hou","year":"2020","journal-title":"Front Psychiatry"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00403","article-title":"Interactive effects of dopamine baseline levels and cycle phase on executive functions: The role of progesterone","volume":"11","author":"Hidalgo-Lopez","year":"2017","journal-title":"Front Neurosci"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.12703\/r\/11-11","article-title":"Recent advances in understanding\/management of premenstrual dysphoric disorder\/premenstrual syndrome","volume":"11","author":"Tiranini","year":"2022","journal-title":"Fac. Rev"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1590\/1516-3180.2023.0156.R1.16022024","article-title":"Smoking and consumption of ultra-processed foods - a combination of risky choices: A cross-sectional study using Vigitel 2018 data","volume":"142","author":"Ruiz","year":"2024","journal-title":"Sao. Paulo. Med J"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.05.014","article-title":"Frontal cortex and reward-guided learning and decision-making","volume":"70","author":"Rushworth","year":"2011","journal-title":"Neuron"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3381","article-title":"The brain reward circuitry in mood disorders","volume":"14","author":"Russo","year":"2013","journal-title":"Nat Rev Neurosci"},{"key":"B52","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1037\/a0023575","article-title":"Decision making and reward in frontal cortex: complementary evidence from neurophysiological and neuropsychological studies","volume":"125","author":"Kennerley","year":"2011","journal-title":"Behav Neurosci"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11092469","article-title":"From reward to anhedonia-dopamine function in the global mental health context","volume":"11","author":"Dresp-Langley","year":"2023","journal-title":"Biomedicines"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyy081","article-title":"Circuit mechanisms of reward, anhedonia, and depression","volume":"22","author":"H\u00f6flich","year":"2019","journal-title":"Int J Neuropsychopharmacol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/s41398-019-0644-x","article-title":"Meta-analysis of reward processing in major depressive disorder reveals distinct abnormalities within the reward circuit","volume":"9","author":"Ng","year":"2019","journal-title":"Transl Psychiatry"},{"key":"B56","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jad.2017.02.001","article-title":"Reward processing and mood-related symptoms: An RDoC and translational neuroscience perspective","volume":"216","author":"Nusslock","year":"2017","journal-title":"J Affect Disord"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.20220423","article-title":"Toward a better understanding of the mechanisms and pathophysiology of anhedonia: Are we ready for translation","volume":"179","author":"Pizzagalli","year":"2022","journal-title":"Am J Psychiatry"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291717003270","article-title":"Brain activation during emotion regulation in women with premenstrual dysphoric disorder","volume":"48","author":"Petersen","year":"2018","journal-title":"Psychol Med"}],"container-title":["Frontiers in Psychiatry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2026.1776826\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T14:18:26Z","timestamp":1780928306000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2026.1776826\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,8]]},"references-count":58,"alternative-id":["10.3389\/fpsyt.2026.1776826"],"URL":"https:\/\/doi.org\/10.3389\/fpsyt.2026.1776826","relation":{},"ISSN":["1664-0640"],"issn-type":[{"value":"1664-0640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,8]]},"article-number":"1776826"}}