{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T06:17:59Z","timestamp":1778221079669,"version":"3.51.4"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002647","name":"Sungkyunkwan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002647","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Parkinson\u2019s disease is a progressive neurodegenerative disorder in which non-motor psychiatric symptoms are common. Anxiety disorder is associated with poorer clinical outcomes and reduced quality of life in Parkinson\u2019s disease, yet population-based evidence on the risk of newly diagnosed anxiety disorder after Parkinson\u2019s disease remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a nationwide population-based matched cohort study using data from the Korean National Health Insurance Service between 2012 and 2023. Incident Parkinson\u2019s disease was identified using diagnostic codes, and anxiety disorder was defined based on repeated clinical diagnoses. Individuals with a prior history of anxiety disorder were excluded using a three-year washout period. Patients with Parkinson\u2019s disease were matched to general population controls at a 1:5 ratio using propensity scores. Incidence rate ratios and adjusted hazard ratios were estimated using time-stratified Cox regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 3,742 patients with Parkinson\u2019s disease and 18,710 matched controls. The incidence rate of anxiety disorder was higher among patients with Parkinson\u2019s disease than among controls (56.62 vs. 28.10 per 1,000 person-years), corresponding to an incidence rate ratio of 2.01. The increased risk was most pronounced during the first three years after diagnosis and again during long-term follow-up, indicating a time-dependent pattern.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with Parkinson\u2019s disease experience a substantially higher incidence of anxiety disorder compared with the general population, with risk varying over the disease course. These findings highlight anxiety disorder as an important non-motor psychiatric manifestation of Parkinson\u2019s disease and support the need for longitudinal mental health monitoring in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyt.2026.1788684","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T05:51:20Z","timestamp":1778219480000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Incidence of anxiety disorders following Parkinson\u2019s disease: a population-based cohort study"],"prefix":"10.3389","volume":"17","author":[{"given":"Youngoh","family":"Bae","sequence":"first","affiliation":[{"name":"Department of Precision Medicine, Sungkyunkwan University School of Medicine","place":["Suwon, Republic of Korea"]},{"name":"Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine","place":["Seoul, Republic of 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