{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:58:37Z","timestamp":1791914317802,"version":"4.3.4"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Schizophrenia is conceptualized as a disorder of brain network dysconnectivity, yet relationships between neural alterations, cognitive deficits, and genetic risk remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We examined 86 participants: schizophrenia patients (SCZ), unaffected siblings (SCZ-SIB), healthy controls (CON), and control siblings (CON-SIB). We used a multiscale graph-theoretic analysis of task-based fMRI during N-back working memory and unsupervised clinical-cognitive clustering.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found that reduced cerebellum-sensorimotor (CER-SM) and cerebellum-cingulo-opercular (CER-CO) connectivity during the 1-back condition robustly discriminated SCZ from CON (AUC = 0.89). Critically, these dysconnectivity patterns were linked to clinical state, present in SCZ vs. SCZ-SIB but absent in SCZ-SIB vs. CON-SIB, suggesting illness expression rather than familial risk. Unsupervised clustering revealed three data-driven subtypes with distinct cognitive- symptomatic profiles: subtype 1 with relative preservation of verbal abilities (predominantly controls), subtype 2 with marked fluid cognitive impairment (enriched in SCZ), and subtype 3 with intermediate performance with working memory sparing (mixed composition). Cerebellar-cortical hypoconnectivity showed graded alignment across these profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These findings demonstrate that cerebellar dysconnectivity is most detectable under moderate cognitive load, tracks with clinical state, and covaries with transdiagnostic cognitive profiles, advancing circuit-based understanding of schizophrenia heterogeneity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyt.2026.1796599","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T05:24:03Z","timestamp":1775107443000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Cerebellar dysconnectivity in schizophrenia spectrum: task-based functional connectivity analysis and cognitive stratification"],"prefix":"10.3389","volume":"17","author":[{"given":"Diana S. M.","family":"Rosales-Gurmendi","sequence":"first","affiliation":[{"name":"School of Engineering and Sciences, Tecnologico de Monterrey","place":["Monterrey, Nuevo Leon, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadam","family":"Hussain","sequence":"additional","affiliation":[{"name":"School of Engineering and Sciences, Tecnologico de Monterrey","place":["Monterrey, Nuevo Leon, Mexico"]},{"name":"School of Medicine and Health Sciences, Tecnologico de Monterrey","place":["Monterrey, Nuevo Leon, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"de Avila-Armenta","sequence":"additional","affiliation":[{"name":"School of Engineering and Sciences, Tecnologico de Monterrey","place":["Monterrey, Nuevo Leon, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo A.","family":"Fumagal-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"School of Engineering and Sciences, Tecnologico de Monterrey","place":["Monterrey, Nuevo Leon, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge A.","family":"Garza-Abdala","sequence":"additional","affiliation":[{"name":"School of Engineering and Sciences, Tecnologico de Monterrey","place":["Monterrey, Nuevo Leon, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alma A.","family":"Pedro-P\u00e9rez","sequence":"additional","affiliation":[{"name":"School of Engineering, Pontificia Universidad Cat\u00f3lica de Chile","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasiel","family":"Toscano","sequence":"additional","affiliation":[{"name":"School of Engineering, Pontificia Universidad Cat\u00f3lica de Chile","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose G.","family":"Tamez-Pe\u00f1a","sequence":"additional","affiliation":[{"name":"School of Engineering and Sciences, Tecnologico de 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