{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T06:15:35Z","timestamp":1778652935158,"version":"3.51.4"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Previous research has identified aberrant functional connectivity (FC) in the neural circuits of patients with bipolar mania (BD-M) and bipolar depression (BD-D), yet the specificity of these FC patterns to each mood state remains unelucidated. This study was designed to compare the cerebral-limbic FC characteristics among BD-M, BD-D patients and healthy control (HC) subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Resting-state functional magnetic resonance imaging (fMRI) was performed on 30 BD-M patients, 31 BD-D patients and 30 HC subjects. Interregional cerebral FC values were calculated for group-wise comparisons, and the correlation between abnormal FC and depressive symptom severity was further explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No significant group differences in cerebral-limbic functional connectivity survived false discovery rate (FDR) correction for multiple comparisons (p&amp;lt;0.05); thus, all reported abnormal FC patterns were identified at a stringent uncorrected statistical threshold of p&amp;lt;0.001 and should be strictly interpreted as exploratory neurofunctional trends without statistical validation at the individual connection level. Abnormal cerebral-limbic FC in the default mode network (DMN), attention network and limbic areas was observed in both BD-M and BD-D groups. Specifically, BD-D patients showed elevated FC mainly in the DMN [posterior cingulate gyrus (PCG), precuneus (PCUN)], attention network [superior parietal gyrus (SPG), inferior parietal gyrus (IPG)] and limbic regions [hippocampus (HIP), parahippocampus (PHG)], while BD-M patients displayed reduced cerebral-limbic FC in the DMN and limbic areas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>BD-M and BD-D show distinct and divergent cerebral-limbic FC patterns: reduced DMN FC in BD-M and increased DMN FC in BD-D. These exploratory patterns suggest potential neurofunctional correlates of mood states in bipolar disorder, offering preliminary clues to state-related differences that require validation in larger independent cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyt.2026.1799295","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T05:57:06Z","timestamp":1778651826000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Abnormalcerebral-limbic functional connectivity between bipolar mania and bipolar depression under resting state"],"prefix":"10.3389","volume":"17","author":[{"given":"Shanghao","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Psychiatry, The Second People\u2019s Hospital of Hunan Province (Brain Hospital of Hunan Province)","place":["Changsha, Hunan, 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