{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:20:05Z","timestamp":1777868405347,"version":"3.51.4"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Traumatic brain injury (TBI) with post-traumatic stress disorder (PTSD) is treatment-resistant, with conventional psychotherapy showing limited efficacy due to neurocognitive impairments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Summary<\/jats:title>\n                    <jats:p>We report two patients with severe TBI and psychiatric comorbidities treated with Prism neurofeedback.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case 1<\/jats:title>\n                    <jats:p>44-year-old female, 35 years post-childhood TBI, with agoraphobia and hyperacusis, achieved 42% PTSD reduction and substantial functional gains (social reintegration, independent driving) sustained through 4-month follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case 2<\/jats:title>\n                    <jats:p>40-year-old male, 3.5 years post-adult TBI with bipolar II disorder and severe PTSD (PCL-5\u00a0=\u00a062), achieved 90% PTSD reduction with complete remission sustained at 1-month follow-up, enabling return to work and family system transformation. Both patients developed personalized regulatory strategies and maintained gains without relapse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Prism neurofeedback demonstrates clinically meaningful outcomes in severe TBI-PTSD where traditional psychotherapy shows limited efficacy. The intervention\u2019s circumvention of cognitive processing demands may explain the favorable outcomes. Controlled trials are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyt.2026.1804685","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T11:53:21Z","timestamp":1777550001000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Prism for PTSD in severe traumatic brain injury with psychiatric comorbidities: two cases"],"prefix":"10.3389","volume":"17","author":[{"given":"Diana","family":"Ghelber","sequence":"first","affiliation":[{"name":"Institute for Advanced Psychiatry","place":["Fort Worth, TX, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tal","family":"Harmelech","sequence":"additional","affiliation":[{"name":"GrayMatters Health","place":["Haifa, Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aron","family":"Tendler","sequence":"additional","affiliation":[{"name":"GrayMatters Health","place":["Haifa, Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2009.08101604","article-title":"Exploring the convergence of posttraumatic stress disorder and mild traumatic brain injury","volume":"166","author":"Stein","year":"2009","journal-title":"Am J Psychiatry"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2011.13.2\/rbryant","article-title":"Post-traumatic stress disorder vs traumatic brain injury","volume":"13","author":"Bryant","year":"2011","journal-title":"Dialogues Clin Neurosci"},{"key":"B3","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/s41562-018-0484-3","article-title":"Electrical fingerprint of the amygdala guides neurofeedback training for stress resilience","volume":"3","author":"Keynan","year":"2019","journal-title":"Nat Hum Behav"},{"key":"B4","doi-asserted-by":"crossref","first-page":"115711","DOI":"10.1016\/j.psychres.2023.115711","article-title":"Amygdala-derived-EEG-fMRI-pattern neurofeedback for the treatment of chronic post-traumatic stress disorder. 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