{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:01:53Z","timestamp":1780470113059,"version":"3.54.1"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"\n Introduction<\/jats:title>\n Cranial Electrotherapy Stimulation (CES) is a non-invasive brain stimulation (NIBS) technique used for anxiety and sleep disorders; however, case-level evidence linking clinical improvement with objective neurophysiological change remains limited. This case presents a multimodal examination of the therapeutic and neurophysiological effects of CES in a patient with sleep disturbances and chronic stress.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A 51-year-old woman with chronic stress, anxiety, and persistent sleep disturbance following thyroid and parathyroid surgery, refractory to pharmacological treatment, underwent a 16-week CES intervention. Outcomes were assessed at baseline and follow-up using EQ-5D-5L, DASS-21, GAD-7, PSQI, and resting-state Electroencephalography (EEG).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Anxiety, stress, and depressive symptoms improved to within normal ranges, alongside significant improvements in mental health-related quality of life. EEG demonstrated increased posterior alpha activity and improved frontal symmetry. Sleep quality showed modest improvement.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This case suggests that CES may be a safe adjunctive intervention associated with symptomatic improvement and changes in neurophysiological patterns in stress-related conditions, supporting further controlled investigation.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fpsyt.2026.1808277","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:05:39Z","timestamp":1780466739000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Multimodal clinical and neurophysiological effects of cranial electrotherapy stimulation in a patient with chronic stress and sleep disturbance"],"prefix":"10.3389","volume":"17","author":[{"given":"Ellie","family":"Mitsi","sequence":"first","affiliation":[{"name":"Research Department, SOZO Brain Center","place":["Nicosia, Cyprus"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Kondratev","sequence":"additional","affiliation":[{"name":"Research Department, SOZO Brain Center","place":["Nicosia, Cyprus"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros","family":"Kattou","sequence":"additional","affiliation":[{"name":"Research Department, SOZO Brain Center","place":["Nicosia, Cyprus"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavria","family":"Georgiou","sequence":"additional","affiliation":[{"name":"Research Department, SOZO Brain Center","place":["Nicosia, Cyprus"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"B1","first-page":"1","volume-title":"The impact of stress on sleep quality: a mediation analysis based on longitudinal 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