{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:55:59Z","timestamp":1790589359137,"version":"4.1.0"},"reference-count":9,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:p>Taxifolin (dihydroquercetin), a potent antioxidant flavonoid, shows promise for neurodegenerative conditions. Our pilot study aimed at evaluation the efficacy and safety of Taxifolin in patients with amnestic mild cognitive impairment (aMCI) and monitored a set of blood measures. Twenty-three patients (18 female; aged 53-87) received dihydroquercetin oral solution for 8 weeks with a 4-week follow-up period in an open-label study design. Thirteen patients with aMCI were monitored as controls. Outcomes were assessed using cognitive status (MMSE, MoCA, FCSRT-IR), neuropsychiatric symptoms\u2019 (NPI-Q, HDRS), and rater's impression (CGI) scales, along with blood measures monitoring (glutathione reductase (GR), glutamate dehydrogenase (GDH), and superoxide dismutase (SOD); plasma neutrophil elastase (NE), alpha-1-proteinase inhibitor (alpha-1PI)). Responder classification using composite Z-score changes was based on all clinical scales. Results: Eleven patients were classified as responders, showing significant MMSE and MoCA improvement (mean +2.73 points, p=0.001) sustained through 4-week follow-up. Non-responders and control group showed slight cognitive decline. Composite Z-score changes at the 4-week follow-up revealed differences between responders\/non-responders (ANOVA F(2,20)=17.38, p=0.001); biomarker analysis revealed difference in NE\/alpha-1PI ratio (p=0.034), SOD (p=0.023), and GR dynamics (p=0.022), which correlated negatively with clinical response (R=-0.547, p=0.007), and baseline GDH (p=0.049). Conclusion: Taxifolin treatment resulted in significant cognitive benefits in ~half of aMCI patients, with effects sustained for one month post-treatment. Biomarker changes reveal possible mechanisms involving oxidative stress modulation and inflammatory pathways. These findings support further controlled trials of Taxifolin in populations at risk of Alzheimer's disease.<\/jats:p>","DOI":"10.3389\/fpsyt.2026.1814042","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:06:36Z","timestamp":1790586396000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pilot clinical study of Taxifolin Aqua effect in patients with amnestic mild cognitive impairment"],"prefix":"10.3389","volume":"17","author":[{"given":"Elena V.","family":"Ponomareva","sequence":"first","affiliation":[{"name":"Federal State Budgetary Scientific Institution Russian Mental Health Research Centre (FSBSI RMHRC)","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalya D.","family":"Selezneva","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Scientific Institution Russian Mental Health Research Centre (FSBSI RMHRC)","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina S.","family":"Boksha","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Scientific Institution Russian Mental Health Research Centre (FSBSI RMHRC)","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga K.","family":"Savushkina","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Scientific Institution Russian Mental Health Research Centre (FSBSI RMHRC)","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana A.","family":"Prokhorova","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Scientific Institution Russian Mental Health Research Centre (FSBSI RMHRC)","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena B.","family":"Tereshkina","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Scientific Institution Russian Mental Health Research Centre (FSBSI RMHRC)","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana A.","family":"Zozulya","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Scientific Institution Russian Mental Health Research Centre (FSBSI RMHRC)","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana I.","family":"Gavrilova","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Scientific Institution Russian Mental Health Research Centre (FSBSI RMHRC)","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor V.","family":"Kolykhalov","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Scientific Institution Russian Mental Health Research Centre (FSBSI RMHRC)","place":["Moscow, 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