{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T06:05:22Z","timestamp":1780380322987,"version":"3.54.1"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to develop and evaluate a culturally adapted psychoeducational intervention to address the severe psychological distress and caregiving burden commonly experienced by caregivers of newly diagnosed pediatric hematologic malignancy patients during the early stages of illness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Among 116 randomized caregivers, 90 completed all three assessments and were included in the complete-case analysis. The intervention group received a 4-week psychoeducation program delivered by medical social workers, whereas the control group received routine care. Outcomes were assessed at baseline, post-intervention, and 48-day follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with controls, caregivers in the intervention group showed greater reductions in depressive and post-traumatic stress symptoms after the intervention, and these reductions were maintained at follow-up. Caregiver burden showed a delayed reduction, with between-group differences becoming apparent at follow-up. Anxiety levels decreased over time in both groups, but the group \u00d7 time interaction was not statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The culturally adapted psychoeducational intervention was associated with reductions in depressive and post-traumatic stress symptoms and a delayed reduction in caregiver burden, but did not show an additional effect on anxiety beyond routine care. These findings provide preliminary support for structured, culturally responsive psychoeducational support in pediatric hematology settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyt.2026.1835671","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:42:19Z","timestamp":1780378939000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of a culturally adapted psychoeducational intervention for family caregivers of children with hematologic malignancy: a randomized controlled trial"],"prefix":"10.3389","volume":"17","author":[{"given":"Zhiyu","family":"Ye","sequence":"first","affiliation":[{"name":"Key Laboratory of Adolescent Cyberpsychology and Behavior (CCNU), Ministry of Education, School of Psychology, Central China Normal University","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Union Hospital,Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisha","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Wuhan Mental Health Center, Department of Psychosomatic, Wuhan Hospital for Psychotherapy, Research Center for Psychological and Health Sciences","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine, Shanghai East Hospital, Tongji University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Wuhan Mental Health Center, Department of Psychosomatic, Wuhan Hospital for Psychotherapy, Research Center for Psychological and Health Sciences","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/nop2.1217","article-title":"Chinese parents' caregiving ability for children with haematological Malignancies: a latent class analysis","volume":"9","author":"Wang","year":"2022","journal-title":"Nurs Open"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2280","DOI":"10.1186\/s12889-025-23469-7","article-title":"Burden of hematologic Malignancies in China from 1990 to 2021: analysis from the Global Burden of Disease Study 2021","volume":"25","author":"Shao","year":"2025","journal-title":"BMC Public Health"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28059","article-title":"Emotional symptoms and family functioning in caregivers of children with newly diagnosed leukemia\/lymphomas and solid tumors: short-term changes and related demographic factors","volume":"67","author":"Peterson","year":"2020","journal-title":"Pediatr Blood Cancer"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.4531","article-title":"Mental health care utilization among parents of children with cancer","volume":"7","author":"Hu","year":"2024","journal-title":"JAMA Netw Open"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25761","article-title":"Standards of psychosocial care for parents of children with cancer","volume":"62","author":"Kearney","year":"2015","journal-title":"Pediatr Blood Cancer"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.3390\/children8111045","article-title":"Utilization of psychotherapeutic interventions by pediatric psychosocial providers","volume":"8","author":"Fair","year":"2021","journal-title":"Children"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1080\/00981389.2018.1441212","article-title":"Psychosocial standards of care for children with cancer and their families: a national survey of pediatric oncology social workers","volume":"57","author":"Jones","year":"2018","journal-title":"Soc Work Health Care"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1177\/1367493518814917","article-title":"The effects of psychoeducational interventions on caregivers of children with cancer: a meta-analysis of randomized controlled trials","volume":"24","author":"Tang","year":"2020","journal-title":"J Child Health Care"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2011.39.1870","article-title":"Specificity of problem-solving skills training in mothers of children newly diagnosed with cancer: results of a multisite randomized clinical trial","volume":"31","author":"Sahler","year":"2013","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/pon.6208","article-title":"Effectiveness of psychoeducation interventions in reducing negative psychological outcomes and improving coping skills in caregivers of children with cancer: a systematic review and meta\u2010analysis","volume":"32","author":"Phiri","year":"2023","journal-title":"Psycho\u2010Oncology"},{"key":"B11","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1007\/s11864-022-00955-3","article-title":"Understanding and supporting informal cancer caregivers","volume":"23","author":"Molassiotis","year":"2022","journal-title":"Curr Treat Options Oncol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1186\/s12888-023-05084-1","article-title":"Decisional conflict, caregiver mastery, and depression among Chinese parental caregivers of children with leukemia","volume":"23","author":"Liu","year":"2023","journal-title":"BMC Psychiatry"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1186\/s12912-025-03444-8","article-title":"Primary caregiver-reported family resilience in children with cancer in central China: a latent profile analysis","volume":"24","author":"Li","year":"2025","journal-title":"BMC Nurs"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1097\/ncc.0000000000001510","article-title":"Patterns identified in parents' cancer disclosure practices: parent and child perspectives","volume":"10","author":"Cheng","year":"2025","journal-title":"Cancer Nurs"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2024.102425","article-title":"Cultural challenges for adapting behavioral intervention frameworks: a critical examination from a cultural psychology perspective","volume":"110","author":"Fischer","year":"2024","journal-title":"Clin Psychol Rev"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2014.05.021","article-title":"Reliability and validity of the Chinese version of the Patient Health Questionnaire (PHQ-9) in the general population","volume":"36","author":"Wang","year":"2014","journal-title":"Gen Hosp Psychiatry"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare9121709","article-title":"Psychometric properties of the generalized anxiety disorder scale-7 item (GAD-7) in a large sample of Chinese adolescents","volume":"9","author":"Sun","year":"2021","journal-title":"Healthcare"},{"key":"B18","doi-asserted-by":"publisher","first-page":"12245","DOI":"10.3390\/ijerph182212245","article-title":"Factor structure and psychometric properties for the PTSD checklist of Chinese adolescents in the closed period after the COVID-19 outbreak","volume":"18","author":"Chen","year":"2021","journal-title":"Int J Environ Res Public Health"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2009.02019.x","article-title":"Zarit caregiver burden interview: development, reliability and validity of the Chinese version","volume":"63","author":"Lu","year":"2009","journal-title":"Psychiatry Clin Neurosci"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-021-06353-z","article-title":"Designing a need-based program for relieving psychological distress of family caregivers of leukemia patients: a randomized controlled trial","volume":"29","author":"Abdullahzadeh","year":"2021","journal-title":"Supportive Care Cancer"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-017-1738-7","article-title":"Examining the effect of peer helping in a coping skills intervention: a randomized controlled trial for advanced gastrointestinal cancer patients and their family caregivers","volume":"27","author":"Mosher","year":"2018","journal-title":"Qual Life Res"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-016-1400-9","article-title":"Long-term effects of a dyadic psycho-educational intervention on caregiver burden and morbidity in partners of patients with heart failure: a randomized controlled trial","volume":"26","author":"Liljeroos","year":"2017","journal-title":"Qual Life Res"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2021.104162","article-title":"Effectiveness of psychoeducational interventions among caregivers of patients with cancer: a systematic review and meta-analysis","volume":"127","author":"Cheng","year":"2021","journal-title":"Int J Nurs Stud"}],"container-title":["Frontiers in Psychiatry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2026.1835671\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:42:19Z","timestamp":1780378939000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2026.1835671\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,2]]},"references-count":23,"alternative-id":["10.3389\/fpsyt.2026.1835671"],"URL":"https:\/\/doi.org\/10.3389\/fpsyt.2026.1835671","relation":{},"ISSN":["1664-0640"],"issn-type":[{"value":"1664-0640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,2]]},"article-number":"1835671"}}