{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T06:23:34Z","timestamp":1787639014356,"version":"build-2736575974"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Post-stroke depression (PSD) is a common complication after stroke that affects prognosis. The triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance, is associated with cerebrovascular diseases, but its relationship with PSD remains unclear. This study investigated the association between TyG index and PSD risk in first-ever acute ischemic stroke (AIS) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We enrolled 398 consecutive first-ever AIS patients and calculated baseline TyG index. PSD was assessed using the 17-item Hamilton Depression Rating Scale at 3 months post-stroke. Logistic regression, restricted cubic splines (RCS), and threshold effect models were used to evaluate the association and dose-response relationship.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At 3 months, 126 patients (31.66%) developed PSD. The PSD group had significantly higher TyG index than the non-PSD group (9.03[8.34\u20139.34] vs. 8.56[8.17\u20139.05], P &amp;lt; 0.001). After adjusting for sex, NIHSS score, LDL-C, and HDL-C, TyG index remained independently associated with PSD (OR\u00a0=\u00a01.64, 95% CI: 1.28\u20132.09, P &amp;lt; 0.001). Patients in the highest TyG quartile had a significantly increased PSD risk compared with the lowest quartile (OR\u00a0=\u00a03.40, 95% CI:1.73\u20136.68, P &amp;lt; 0.001). RCS analysis revealed a non-linear relationship, with a turning point at 8.02 identified by threshold effect analysis; above this value, PSD risk increased significantly (OR\u00a0=\u00a01.97, 95% CI:1.43\u20132.72, P &amp;lt; 0.001). Subgroup analyses showed significant interactions in patients with diabetes (P for interaction = 0.046) and hyperlipidemia (P for interaction = 0.026).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Elevated TyG index is independently associated with increased PSD risk in a non-linear manner. A TyG index \u2265 8.02 may serve as a risk threshold for PSD, and this association appears more pronounced in patients with diabetes or hyperlipidemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyt.2026.1877775","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:34:30Z","timestamp":1787636070000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between the triglyceride-glucose index and the risk of post-stroke depression"],"prefix":"10.3389","volume":"17","author":[{"given":"Xiaohang","family":"Su","sequence":"first","affiliation":[{"name":"Department of Neurology, The Affiliated Hospital of Qingdao University","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jueyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Hospital of Qingdao University","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Hospital of Qingdao University","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Hospital of Qingdao University","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00252-0","article-title":"Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"20","year":"2021","journal-title":"Lancet 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