{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:30:17Z","timestamp":1787646617933,"version":"build-2736575974"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Brain metastases after resection of primary non-small cell lung cancer (NSCLC) impose substantial burdens. We examined the concurrent association between psychological resilience and global health status\/quality of life (GHS\/QoL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single-center retrospective study included 207 adults who first developed brain metastases after primary NSCLC resection. Records from the 25-item Connor-Davidson Resilience Scale (CD-RISC), European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30), and European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Brain Neoplasm Module 20 (EORTC QLQ-BN20), collected at the same clinically stable outpatient assessment 4\u201312 weeks after brain-metastasis diagnosis, were linked to retrospectively extracted clinical data. Pearson correlations and a prespecified full-covariate multivariable linear regression model were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CD-RISC scores correlated positively with all QLQ-C30 functioning scales and GHS\/QoL and negatively with the three QLQ-C30 symptom scales and four QLQ-BN20 multi-item symptom scales (all Benjamini\u2013Hochberg-adjusted\n                      <jats:italic>q\u00a0<\/jats:italic>\n                      &amp;lt;\u00a00.001). Each 1-point increase in CD-RISC total score was associated with a 0.452-point higher adjusted GHS\/QoL score (95% confidence interval, 0.326\u20130.578;\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      &amp;lt;\u00a00.001). Higher Karnofsky Performance Status and college-level education were associated with higher GHS\/QoL, whereas pretreatment clinical tumor-node-metastasis stage IIIB or IVA, \u22654 brain metastases, and 30-day complications after lung resection were associated with lower GHS\/QoL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Greater psychological resilience was concurrently associated with better GHS\/QoL and lower QLQ-BN20 multi-item symptom scores. These findings support integrated assessment of resilience, function, and symptoms; temporal direction requires longitudinal confirmation, and intervention effects require prospective trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyt.2026.1890412","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:03:43Z","timestamp":1787645023000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between psychological resilience and global health status\/quality of life in patients with brain metastases after resection of primary non-small cell lung cancer"],"prefix":"10.3389","volume":"17","author":[{"given":"Caijun","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Ningbo Second Hospital","place":["Ningbo, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafen","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ningbo Second Hospital","place":["Ningbo, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000003268","article-title":"Global burden of lung cancer in 2022 and projected burden in 2050","volume":"137","author":"Guo","year":"2024","journal-title":"Chin Med J (Engl)"},{"key":"B2","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s00408-025-00801-x","article-title":"Update 2025: management of non-small-cell lung cancer","volume":"203","author":"Jeon","year":"2025","journal-title":"Lung"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2022.101058","article-title":"Brain metastasis incidence and patterns of presentation after 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