{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T07:16:25Z","timestamp":1788419785062,"version":"build-2803163510"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Data on young-onset dementia (YOD) in Thailand remain limited. We aimed to describe clinical presentation, general cognitive performance, neuropsychiatric symptoms, neuroimaging features, and selected laboratory findings across YOD subtypes in a tertiary-care cohort in Northern Thailand.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cross-sectional study of 295 individuals with YOD (symptom onset &amp;lt; 65 years) treated at Chiang Mai University Hospital (2010\u20132025). Data extracted included demographics, presenting complaints, general cognitive scores (MoCA\/TMSE\/MSET-10), neuropsychiatric symptoms (NPI-Q, TGDS), functional status, neuroimaging findings, and laboratory results (HIV, syphilis serology, glycemic indices, and lipid profiles).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Alzheimer\u2019s disease (AD) and vascular dementia (VaD) were the most common subtypes. Memory impairment was the most frequent presenting complaint overall (78.3%) and was more common in AD than VaD (93.4% vs 77.8%), whereas behavioral change was more common in VaD than AD (31.1% vs 13.2%). General cognitive scores did not significantly differ between AD and VaD. Neuropsychiatric symptoms were frequent, with aberrant motor behavior (42.2%) and irritability\/lability (35.1%) being the most prevalent domains. Regarding neuroimaging features, a substantial burden of subcortical and basal ganglia lesions co-occurred predominantly within the VaD group. Behavioral variant frontotemporal dementia (bvFTD) accounted for 3.7% of cases; most met the International Behavioral Variant FTD Criteria Consortium (FTDC) criteria for probable bvFTD. All tested participants had non-reactive HIV results, and reactive syphilis screening results were uncommon and were not supported by confirmatory treponemal testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Presenting complaints differed between young-onset AD and VaD despite similar general cognitive performance, underscoring the importance of informant history and multimodal assessment for accurate subtyping. Frequent motor-related neuropsychiatric symptoms highlight the clinical relevance of subcortical\/basal ganglia lesion burden in this cohort.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyt.2026.1912953","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T06:43:10Z","timestamp":1788417790000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical characteristics and neuropsychiatric profiles of young-onset dementia: a retrospective cross-sectional study at a tertiary care center in Northern Thailand"],"prefix":"10.3389","volume":"17","author":[{"given":"Sirivipa","family":"Jekpoo","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, Chiang Mai University","place":["Chiang Mai, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kittithatch","family":"Booncharoen","sequence":"additional","affiliation":[{"name":"Center of Medical Excellence, Faculty of Medicine, Chiang Mai University","place":["Chiang Mai, Thailand"]},{"name":"Northern Neuroscience Center, Faculty of Medicine, Chiang Mai University","place":["Chiang Mai, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supisara","family":"Prompila","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, Chiang Mai University","place":["Chiang Mai, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tinakon","family":"Wongpakaran","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, Chiang Mai University","place":["Chiang Mai, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huali","family":"Wang","sequence":"additional","affiliation":[{"name":"Dementia Care and Research Center, Peking University Institute of Mental Health (Sixth Hospital)","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahathai","family":"Wongpakaran","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, Chiang Mai University","place":["Chiang Mai, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1017\/s1041610214001574","article-title":"Young onset dementia \u2013 what does the name imply","volume":"26","author":"Koopmans","year":"2014","journal-title":"Int Psychogeriatrics"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.2161","article-title":"Global prevalence 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