{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T07:16:00Z","timestamp":1788419760635,"version":"build-2803163510"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2024-00458451, RS-2026-25489827"],"award-info":[{"award-number":["RS-2024-00458451, RS-2026-25489827"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Late-life depression often co-occurs with cognitive difficulty, but whether amyloid burden is associated with mood and cognitive change during transcranial direct current stimulation (tDCS) in older adults is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this single-arm pre\u2013post study, 41 older adults were enrolled; 3 withdrew before receiving the device, and 38 received home-based tDCS and completed baseline (V1), post-stimulation (V2), and follow-up (V3) assessments. Depression, insomnia, subjective cognition, MoCA, and a detailed cognitive battery were examined, and 31 change outcomes were regressed on Centiloid and 21 regional amyloid indicators with covariate adjustment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No participant met the \u226550% GDS response criterion, whereas 60.5% showed a \u22652-point MoCA gain; the absent depression response reflects a floor effect expected from the low baseline severity rather than inefficacy. No association survived Benjamini\u2013Hochberg correction across the complete exploratory family. In a biologically motivated Centiloid-only analysis, however, greater Centiloid burden was associated with smaller MoCA gain, and this association survived correction in both the full-analysis and per-protocol sets. Phonemic-fluency findings were less stable, and no comparable FDR-supported association was detected for depression, insomnia, or subjective cognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings do not support a broad amyloid-related cognitive pattern, but they identify a focused, hypothesis-generating Centiloid\u2013MoCA association during the protocol. Because the study was single-arm, neither the observed changes nor the amyloid association can be attributed to stimulation itself. Controlled studies with prespecified outcomes are required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyt.2026.1916856","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T06:42:42Z","timestamp":1788417762000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Baseline amyloid burden and global cognitive change during a home-based tDCS protocol in late-life depression: an exploratory single-arm study"],"prefix":"10.3389","volume":"17","author":[{"given":"Yiran","family":"Li","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Yongin Severance Hospital","place":["Yongin, Gyeonggi, Republic of Korea"]},{"name":"Institute of Behavioral Science in Medicine, College of Medicine, Yonsei University","place":["Seoul, Republic of Korea"]},{"name":"Yonsei Graduate Program in Cognitive Science, Yonsei University","place":["Seoul, Republic of 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