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Psychiatry"],"abstract":"<jats:p>Dementia with Lewy bodies (DLB) is characterized by visual hallucinations. Isolated auditory hallucinations as the presenting psychiatric symptom are uncommon, and misdiagnosis as a primary psychiatric disorder with consequent inappropriate antipsychotic exposure is a substantial risk. A case of probable DLB presenting with isolated auditory hallucinations as the initial manifestation, accompanied by RBD, parkinsonism, and characteristic neuroimaging findings, is described. Initial misdiagnosis as schizophrenia led to severe adverse reactions to antipsychotic agents. After multimodal evaluation, treatment with a cholinesterase inhibitor, combined with a monoamine oxidase-B inhibitor and a melatonin receptor agonist, improved motor and sleep symptoms, and the patient\u2019s condition gradually stabilized. Although isolated auditory hallucinations are not a typical presenting feature of DLB, they should be regarded as a warning signal for \u03b1-synucleinopathy when occurring against a background of neurodegeneration accompanied by RBD, autonomic dysfunction, or Parkinsonism. When clinical features satisfy the criteria for probable DLB, core clinical features are sufficient to establish the diagnosis; cholinesterase inhibitors should be the first-line treatment for neuropsychiatric symptoms in DLB.<\/jats:p>","DOI":"10.3389\/fpsyt.2026.1935514","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:29:00Z","timestamp":1789104540000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Isolated auditory hallucinations as the initial neuropsychiatric manifestation of dementia with Lewy bodies: diagnostic pathway and individualized therapy (a case report)"],"prefix":"10.3389","volume":"17","author":[{"given":"Lijun","family":"Hou","sequence":"first","affiliation":[{"name":"Department of Neurology, Qujing Second People\u2019s Hospital","place":["Qujing, Yunnan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingmei","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qujing Second People\u2019s Hospital","place":["Qujing, Yunnan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunfang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qujing Second People\u2019s Hospital","place":["Qujing, Yunnan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qujing Second People\u2019s Hospital","place":["Qujing, Yunnan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiying","family":"Peng","sequence":"additional","affiliation":[{"name":"Qujing Medical College","place":["Qujing, Yunnan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/s12883-021-02169-w","article-title":"Clinical characteristics of Lewy body dementia in Chinese memory clinics","volume":"21","author":"Gan","year":"2021","journal-title":"BMC Neurol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1212\/wnl.0000000000004919","article-title":"Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium","volume":"89","author":"McKeith","year":"2017","journal-title":"Neurology"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1017\/s0033291718003161","article-title":"Auditory and visual hallucination prevalence in Parkinson's disease and dementia with Lewy bodies: a systematic review and meta-analysis","volume":"49","author":"Eversfield","year":"2019","journal-title":"Psychol Med"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1099-1166(199906)14:6<459::aid-gps957>3.0.co;2-r","article-title":"Olanzapine in dementia with Lewy bodies: a clinical study","volume":"14","author":"Walker","year":"1999","journal-title":"Int J Geriatr Psychiatry"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.2.172","article-title":"Late-onset schizophrenia and very-late-onset schizophrenia-like psychosis: an international consensus. 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