{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:09:41Z","timestamp":1789711781737,"version":"4.0.1"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate gray matter volume (GMV) differences related to psychiatric manifestations in patients with Wilson disease (WD) and to examine the effect of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In 102 patients with WD, 3.0T T1-weighted MRI scans were analyzed using voxel-based morphometry. Patients were divided into younger (\u226430 years) and older (&amp;gt;30 years) groups and were further grouped according to psychiatric manifestations. Patients with a UWDRS psychiatric subscale (UWDRS-PSY) score of 0 were classified as having no psychiatric manifestations, and those with a score &amp;gt;0 were classified as having psychiatric manifestations. Two-way ANCOVA was performed with total intracranial volume, sex, and education as covariates. Cluster-level family-wise error (FWE) correction was applied. Mean GMV values were extracted from significant caudate clusters and correlated with UWDRS-PSY scores as exploratory analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Significant interactions between age group and psychiatric manifestations were found in the left insula\/Rolandic operculum and right inferior temporal gyrus. Lower GMV in these regions was mainly found in younger patients with psychiatric manifestations. A main effect of psychiatric manifestations was found in the bilateral caudate nuclei, with lower GMV in patients with psychiatric manifestations. Lower caudate GMV was also associated with higher UWDRS-PSY scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Psychiatric manifestations in WD are associated with distinct gray matter patterns that vary with age, while bilateral caudate involvement may represent a more consistent structural correlate. These findings highlight the potential importance of considering age when examining the neuroanatomical correlates of psychiatric manifestations in WD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyt.2026.1960346","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:38:34Z","timestamp":1789709914000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuroanatomical correlates of psychiatric manifestations in Wilson disease: the role of age"],"prefix":"10.3389","volume":"17","author":[{"given":"Anqin","family":"Wang","sequence":"first","affiliation":[{"name":"Imaging Center, The First Affiliated Hospital of Anhui University of Chinese Medicine","place":["Hefei, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunsheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Imaging Center, The First Affiliated Hospital of Anhui 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