{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T04:19:56Z","timestamp":1782015596011,"version":"3.54.5"},"reference-count":109,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T00:00:00Z","timestamp":1608076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold>It is widely known that the harmful effects of fine dust can cause various diseases. Research on the correlation between fine dust and health has been mainly focused on lung and cardiovascular diseases. By contrast, the effects of air pollution on the central nervous system (CNS) are not broadly recognized.<\/jats:p><jats:p><jats:bold>Findings:<\/jats:bold>Air pollution can cause diverse neurological disorders as the result of inflammation of the nervous system, oxidative stress, activation of microglial cells, protein condensation, and cerebral vascular-barrier disorders, but uncertainty remains concerning the biological mechanisms by which air pollution produces neurological disease. Neuronal cell damage caused by fine dust, especially in fetuses and infants, can cause permanent brain damage or lead to neurological disease in adulthood.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold>It is necessary to study the air pollution\u2013CNS disease connection with particular care and commitment. Moreover, the epidemiological and experimental study of the association between exposure to air pollution and CNS damage is critical to public health and quality of life. Here, we summarize the correlations between fine dust exposure and neurological disorders reported so far and make suggestions on the direction future research should take.<\/jats:p>","DOI":"10.3389\/fpubh.2020.575330","type":"journal-article","created":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T13:07:58Z","timestamp":1610284078000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":189,"title":["Air Pollution and Central Nervous System Disease: A Review of the Impact of Fine Particulate Matter on Neurological Disorders"],"prefix":"10.3389","volume":"8","author":[{"given":"Hyunyoung","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Ho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Youl","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Young","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,12,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"30755","DOI":"10.1007\/s11356-019-06382-6","article-title":"Characteristics of cohort studies of long-term exposure to PM2.5: a systematic review","volume":"26","author":"Nabizadeh","year":"2019","journal-title":"Environ Sci Pollut Res Int."},{"key":"B2","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1017\/S146342361400036X","article-title":"Air pollution and your brain: what do you need to know right now","volume":"16","author":"Calderon-Garciduenas","year":"2015","journal-title":"Prim Health Care Res Dev."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1289\/EHP136","article-title":"Effects of ambient air pollution exposure on olfaction: a review","volume":"124","author":"Ajmani","year":"2016","journal-title":"Environ Health Perspect."},{"key":"B4","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.neuro.2015.11.008","article-title":"Neurotoxicity of traffic-related air pollution","volume":"59","author":"Costa","year":"2017","journal-title":"Neurotoxicology."},{"key":"B5","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1093\/neuonc\/nox163","article-title":"Long-term exposure to ambient air pollution and incidence of brain tumor: the European Study of Cohorts for Air Pollution Effects (ESCAPE)","volume":"20","author":"Andersen","year":"2018","journal-title":"Neuro Oncol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1177\/1352458517726866","article-title":"Air pollution is associated to the multiple sclerosis inflammatory activity as measured by brain MRI","volume":"24","author":"Bergamaschi","year":"2018","journal-title":"Mult Scler."},{"key":"B7","doi-asserted-by":"publisher","first-page":"126002","DOI":"10.1289\/EHP4595","article-title":"Air pollution (particulate matter) exposure and associations with depression, anxiety, bipolar, psychosis and suicide risk: a systematic review and meta-analysis","volume":"127","author":"Braithwaite","year":"2019","journal-title":"Environ Health Perspect."},{"key":"B8","doi-asserted-by":"publisher","first-page":"573","DOI":"10.3233\/JAD-140855","article-title":"Ozone, particulate matter, and newly diagnosed Alzheimer's disease: a population-based cohort study in Taiwan","volume":"44","author":"Jung","year":"2015","journal-title":"J Alzheimers Dis."},{"key":"B9","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1289\/ehp.1002767","article-title":"Traffic-related air pollution and cognitive function in a cohort of older men","volume":"119","author":"Power","year":"2011","journal-title":"Environ Health Perspect."},{"key":"B10","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1001\/archinternmed.2011.683","article-title":"Exposure to particulate air pollution and cognitive decline in older women","volume":"172","author":"Weuve","year":"2012","journal-title":"Arch Intern Med."},{"key":"B11","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1289\/ehp.1408973","article-title":"Long-term PM2.5 exposure and neurological hospital admissions in the northeastern United States","volume":"124","author":"Kioumourtzoglou","year":"2016","journal-title":"Environ Health Perspect."},{"key":"B12","doi-asserted-by":"publisher","first-page":"e022404","DOI":"10.1136\/bmjopen-2018-022404","article-title":"Are noise and air pollution related to the incidence of dementia? 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