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SARS-CoV-2 directly interacts with angiotensin-converting enzyme 2 (ACE-2) receptors in the human body. Complementary therapies that impact on expression of IgE and IgG antibodies, including administration of bee venom (BV), have efficacy in the management of arthritis, and Parkinson's disease. A recent epidemiological study in China showed that local beekeepers have a level of immunity against SARS-CoV-2 with and without previous exposure to virus. BV anti-inflammatory properties are associated with melittin and phospholipase A2 (PLA2), both of which show activity against enveloped and non-enveloped viruses, including H1N1 and HIV, with activity mediated through antagonist activity against interleukin-6 (IL-6), IL-8, interferon-\u03b3 (IFN-\u03b3), and tumor necrosis factor-\u03b1 (TNF-\u03b1). Melittin is associated with the underexpression of proinflammatory cytokines, including nuclear factor-kappa B (NF-\u03baB), extracellular signal-regulated kinases (ERK1\/2), and protein kinase Akt. BV therapy also involves group III secretory phospholipase A<jats:sub>2<\/jats:sub>in the management of respiratory and neurological diseases. BV activation of the cellular and humoral immune systems should be explored for the application of complementary medicine for the management of SARS-CoV-2 infections. BV \u201cvaccination\u201d is used to immunize against cytomegalovirus and can suppress metastases through the PLA2 and phosphatidylinositol-(3,4)-bisphosphate pathways. That BV shows efficacy for HIV and H1NI offers opportunity as a candidate for complementary therapy for protection against SARS-CoV-2.<\/jats:p>","DOI":"10.3389\/fpubh.2020.594458","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T04:49:30Z","timestamp":1607575770000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":40,"title":["Bee Venom\u2014A Potential Complementary Medicine Candidate for SARS-CoV-2 Infections"],"prefix":"10.3389","volume":"8","author":[{"given":"Keneth Iceland","family":"Kasozi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gniewko","family":"Niedba\u0142a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Alqarni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Zirintunda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred","family":"Ssempijja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon Peter","family":"Musinguzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibe Michael","family":"Usman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Matama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helal F.","family":"Hetta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ngala Elvis","family":"Mbiydzenyuy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaber El-Saber","family":"Batiha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amany Magdy","family":"Beshbishy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan Christina","family":"Welburn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,12,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e480","DOI":"10.1016\/S2214-109X(20)30068-1","article-title":"Potential association between COVID-19 mortality and health-care resource availability","volume":"8","author":"Ji","year":"2020","journal-title":"Lancet GlobHealth"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/S0140-6736(20)30628-0","article-title":"COVID-19: consider cytokine storm syndromes and immunosuppression","volume":"395","author":"Mehta","year":"2020","journal-title":"Lancet"},{"key":"B3","unstructured":"Coronavirus disease 2019(COVID-19) Situation Report-72 HIGHLIGHTS2020"},{"key":"B4","unstructured":"Coronavirus disease 2019(COVID-19) Situation Report \u2013 882020"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2807\/1560-7917.ES.2020.25.10.2000180","article-title":"Estimating the asymptomatic proportion of coronavirus disease 2019. 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