{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T01:17:40Z","timestamp":1771982260576,"version":"3.50.1"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold><jats:italic>Pneumocystis<\/jats:italic> pneumonia (PCP) is one of the most common opportunistic infections in HIV-infected patients. However, coinfection with <jats:italic>Tropheryma whipplei<\/jats:italic> is infrequent in AIDS patients with PCP.<\/jats:p><jats:p><jats:bold>Case Presentation:<\/jats:bold> We report a 28-year-old male AIDS patient coinfected with <jats:italic>T. whipplei<\/jats:italic> and <jats:italic>Pneumocystis jirovecii<\/jats:italic> diagnosed in the bronchoalveolar lavage. After sulfamethoxazole\u2013trimethoprim and meropenem treatment, the patient showed clinical improvement in 2 weeks.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Clinicians need to be alert to the occurrence of <jats:italic>T. whipplei<\/jats:italic> infection in AIDS patients with PCP and timely diagnosis and antibacterial treatments are essential. This case may help clinicians for timely diagnosis of the coinfection of <jats:italic>T. whipplei<\/jats:italic> and <jats:italic>P. jirovecii<\/jats:italic> in AIDS patients.<\/jats:p>","DOI":"10.3389\/fpubh.2021.663093","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T09:45:55Z","timestamp":1628847955000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Case Report: Tropheryma whipplei Hide in an AIDS Patient With Pneumocystis Pneumonia"],"prefix":"10.3389","volume":"9","author":[{"given":"Jun","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binhai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongdong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinchuan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shourong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjiang","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,8,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1186\/s13054-018-2221-8","article-title":"Clinical 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America","volume":"58","author":"Masur","year":"2014","journal-title":"Clin Infect Dis."},{"key":"B11","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/j.cmi.2016.07.010","article-title":"Tropheryma whipplei DNA in bronchoalveolar lavage samples: a case control study","volume":"22","author":"Lagier","year":"2016","journal-title":"Clin Microbiol Infect."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1007\/s10096-014-2054-6","article-title":"(1-3)-beta-D-glucan in association with lactate dehydrogenase as biomarkers of Pneumocystis pneumonia (PcP) in HIV-infected patients","volume":"33","author":"Esteves","year":"2014","journal-title":"Eur J Clin Microbiol Infect Dis."},{"key":"B13","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1128\/CMR.00033-16","article-title":"Clinical manifestations, treatment, and diagnosis of Tropheryma whipplei infections","volume":"30","author":"Dolmans","year":"2017","journal-title":"Clin Microbiol 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