{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T16:49:27Z","timestamp":1775321367348,"version":"3.50.1"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T00:00:00Z","timestamp":1635120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:p>Whipple's disease is a very rare systemic infectious disease, and very few cases have been reported. However, it can be fatal if not diagnosed and treated appropriately. The major clinical manifestations of this disease are usually digestive and nervous system symptoms. The majority of patients are male and between 40 and 50 years old. Although respiratory symptoms of this disease have rarely been reported, they pose a serious threat to the lives of the patients, especially when they progress to severe pneumonia. During admission to the hospital, <jats:italic>Acinetobacter baumannii<\/jats:italic> infection makes treatment more difficult. While most patients are middle-aged men, more attention should be given to the diagnosis and treatment of affected young women. To our knowledge, the case presented in the study is the first case of <jats:italic>Tropheryma whipplei<\/jats:italic> infection that resulted in severe pneumonia and was complicated by <jats:italic>A. baumannii<\/jats:italic> infection during treatment. We hope that our study can serve as a reference for the diagnosis and treatment of related cases in the future.<\/jats:p>","DOI":"10.3389\/fpubh.2021.729595","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T04:56:30Z","timestamp":1635137790000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Severe Pneumonia Caused by Infection With Tropheryma whipplei Complicated With Acinetobacter baumannii Infection: A Case Report Involving a Young Woman"],"prefix":"10.3389","volume":"9","author":[{"given":"Sheng","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demeng","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianghong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuogui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,10,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1007\/s10096-015-2357-2","article-title":"Prevalence of Whipple's disease in north-western Italy","volume":"34","author":"Biagi","year":"2015","journal-title":"Eur J Clin Microbial Infect Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"108","DOI":"10.4321\/S1130-01082010000200006","article-title":"Whipple's disease in Spain: a clinical review of 91 patients diagnosed between 1947 and 2001","volume":"102","author":"Ojeda","year":"2010","journal-title":"Rev Esp Enferm Dig."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000001466","article-title":"Whipple Disease and ankylosing spondylitis-a case report","author":"Martins","year":"2020","journal-title":"J clin rheumatol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e104","DOI":"10.1097\/DAD.0000000000001925","article-title":"A case of Whipple Disease with cutaneous manifestations","volume":"43","author":"Borretta","year":"2021","journal-title":"Am J Dermatopathol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1080\/09273948.2018.1518461","article-title":"Ocular Whipple disease: report of three cases","volume":"27","author":"Testi","year":"2019","journal-title":"Ocul Immunol Inflamm."},{"key":"B6","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1146\/annurev-pathmechdis-012418-012751","article-title":"Clinical metagenomic next-generation sequencing for pathogen detection","volume":"14","author":"Gu","year":"2019","journal-title":"Annu Rev Pathol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"599756","DOI":"10.3389\/fmicb.2020.599756","article-title":"Diagnostic value of metagenomic next-generation sequencing for the detection of pathogens in bronchoalveolar lavage fluid in ventilator-associated pneumonia patients","volume":"11","author":"Fang","year":"2020","journal-title":"Front Microbiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1111\/apt.13140","article-title":"T. 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