{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:10:04Z","timestamp":1793391004523,"version":"4.5.0"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009331","name":"Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support","doi-asserted-by":"publisher","award":["ZYLX202126"],"award-info":[{"award-number":["ZYLX202126"]}],"id":[{"id":"10.13039\/501100009331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["Z191100006619045"],"award-info":[{"award-number":["Z191100006619045"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009601","name":"Beijing Municipal Administration of Hospitals","doi-asserted-by":"publisher","award":["DFL20191802"],"award-info":[{"award-number":["DFL20191802"]}],"id":[{"id":"10.13039\/501100009601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The introduction of antiretroviral therapy (ART) has resulted in marked reductions in morbidity among people living with HIV (PLWH). Monitoring the hospitalizations of PLWH is important in evaluating the quality of healthcare and forecasting the co-morbidity pattern. We aimed to describe the trends in the rates and causes of hospitalization among PLWH who initiated ART in an HIV-designated hospital in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PLWH who initiated ART and were hospitalized in Beijing Ditan Hospital from 2008 to 2020 were selected for the study. Hospitalizations were classified based on AIDS-defining events (ADEs), non-AIDS-defining events (nADEs), and other causes. Hospitalization rates were calculated in terms of person-years, with risk factors determined by Poisson regression. The proportion of hospitalization causes at different ART treatment statuses was also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 9,404 patients (94.7% were male patients) were included, contributing to 49,419 person-years. Overall, 1,551 PLWH were hospitalized for 2,667 hospitalization events, among which 60.4% of hospitalizations were due to ADEs, 11.4% were due to nADEs, and 28.2% were due to other causes. Unadjusted hospitalization rates decreased for all causes and all three diagnostic categories with year. After adjusting for the variables that changed substantially over time, ADE-related [IRR, 1.01 (0.96\u20131.05)] and nADE-related hospitalization rates [IRR, 0.92 (0.84\u20131.01)] appeared stable. Hospitalization for ADEs constituted an increasing proportion over time (36.3% in 2008\u201357.4% in 2020), especially in ART-naive inpatients (43.8% in 2008\u201383.3% in 2020). The proportion of nADE-related hospitalizations remained low (9.0% in 2008\u201315.4% in 2020). Hospitalization rate was highest for patients treated with ART during the first 6 months after ART initiation (46.2%) when ADEs were still the leading cause of hospitalizations (30.6%). Older age, non-men who have sex with men transmission, late presenters, HIV viral load (VL) &amp;gt; 50 copies\/mL, and CD4 counts \u2264 200 cells\/\u03bcL were associated with a higher hospitalization risk (all <jats:italic>P<\/jats:italic> &amp;lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite some progress, ADEs remain the most common and serious problem among PLWH in China. In order to avoid deteriorating to the stage of needing hospitalization, more work is needed to diagnose and treat HIV infection earlier.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2022.1000942","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T16:31:48Z","timestamp":1667925108000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Trends in rates and causes of hospitalization among people living with HIV in the antiretroviral therapy era: A retrospective cohort study in China, 2008\u20132020"],"prefix":"10.3389","volume":"10","author":[{"given":"Ying","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyuan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1038\/sj.cr.7290362","article-title":"Current progress of China's free ART program","volume":"15","author":"Zhang","year":"2005","journal-title":"Cell Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1007\/s11904-019-00471-4","article-title":"History of the HIV epidemic in china","volume":"16","author":"Wu","year":"2019","journal-title":"Curr HIV\/AIDS Rep."},{"key":"B3","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1097\/00000441-200407000-00007","article-title":"Metabolic complications associated with the use of highly active antiretroviral therapy in HIV-1-infected adults","volume":"328","author":"Monier","year":"2004","journal-title":"Am J Med Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1097\/QAD.0b013e328304b38b","article-title":"Rates of hospitalizations and associated diagnoses in a large multisite cohort of HIV patients in the United States, 1994-2005","volume":"22","author":"Buchacz","year":"2008","journal-title":"AIDS (London)."},{"key":"B5","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1093\/cid\/cix343","article-title":"Hospitalization rates among people with HIV\/AIDS in new york city, 2013","volume":"65","author":"Lazar","year":"2017","journal-title":"Clin Infect Dis."},{"key":"B6","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1111\/j.1468-1293.2004.00250.x","article-title":"Changes in hospital admissions across Europe: 1995-2003. 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