{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T07:10:34Z","timestamp":1778224234477,"version":"3.51.4"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T00:00:00Z","timestamp":1666915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Pre-exposure prophylaxis (PrEP) has become a useful tool to reduce the transmission of human immunodeficiency virus (HIV) in key populations. In this article we assessed the effectiveness, safety, adherence, sexually transmitted infections (STIs) dynamics, and frequency of anal dysplasia among a real-life cohort of PrEP users in Northwest Spain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study was undertaken in the Alvaro-Cunqueiro Hospital, Vigo which included every individual who started daily emtricitabine\/tenofovir-disoproxil-fumarate (FTC\/TDF) between November-2019 and October-2021. Clinical and epidemiological data were obtained from the patient's medical records. The effectiveness and safety of FTC\/TDF were assessed by HIV serology and renal function monitoring every 3 months. Anal, urethral, and oropharyngeal exudates were collected quarterly after the baseline visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 126 individuals were considered eligible, most of the participants had previously been diagnosed with a STI (60.3%), 22% had consumed recreational drugs in the year prior, and 13% had engaged in chemsex. At the end of the follow-up, no cases of HIV infection were detected; 3 patients had discontinued FTC\/TDF because of side effects but none of them had presented renal toxicity. In addition, the diagnosis of STIs during the follow-up was common (100 cases in 54 patients). Moreover, engagement in chemsex was more common within this latter group (22 vs. 6%, <jats:italic>p<\/jats:italic> = 0.013). Among the study population included in the anal screening programme, the frequency of dysplasia was 9%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FTC\/TDF was effective, safe, and tolerable in a real-life cohort; adherence remained high throughout the study period (79%). However, a high number of STIs were diagnosed, especially among patients who engaged in chemsex.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2022.1005622","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T07:20:37Z","timestamp":1666941637000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Real-life cohort experience after implementing HIV pre-exposure prophylaxis for one year in northwest Spain"],"prefix":"10.3389","volume":"10","author":[{"given":"Alexandre","family":"P\u00e9rez-Gonz\u00e1lez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Represa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pep","family":"Coll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Potel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Rodr\u00edguez-Rivero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erene V.","family":"Flores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"V\u00e1zquez-Est\u00e9vez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Ocampo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Pousada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Poveda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"722247","DOI":"10.3389\/fmed.2021.722247","article-title":"Implementation and Access to Pre-exposure Prophylaxis for Human Immunodeficiency Virus by Men Who Have Sex With Men in Europe","volume":"8","author":"Sepodes","year":"2021","journal-title":"Front Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2237","DOI":"10.1056\/NEJMoa1506273","article-title":"le Gall J-M, Cua E, Pasquet A, et al","volume":"373","author":"Molina","year":"2015","journal-title":"On-Demand Preexposure Prophylaxis in Men at High Risk for HIV-1 Infection N Engl J Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/jia2.25795","article-title":"Comparison between daily and on-demand PrEP (pre-exposure prophylaxis) regimen in covering condomless anal intercourse for men who have sex with men in Hong Kong: A randomized, controlled, open-label, crossover trial","volume":"24","author":"Kwan","year":"2021","journal-title":"J Int AIDS Soc."},{"key":"B4","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1097\/QAD.0000000000002456","article-title":"HIV preexposure prophylaxis with tenofovir disoproxil fumarate\/emtricitabine and changes in kidney function and tubular health","volume":"34","author":"Ascher","year":"2020","journal-title":"AIDS."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25420\/full","article-title":"Changes in kidney function among men having sex with men starting on demand tenofovir disoproxil fumarate-emtricitabine for HIV pre-exposure prophylaxis","author":"Liegeon","year":"2020","journal-title":"J Int AIDS Soc"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1080\/03007995.2020.1816538","article-title":"Association of tenofovir disoproxil fumarate exposure with chronic kidney disease and osteoporotic fracture in US veterans with HIV","volume":"36","author":"Sutton","year":"2020","journal-title":"Curr Med Res Opin."},{"key":"B7","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1080\/25787489.2021.1955197","article-title":"eGFR-EPI changes among HIV patients who switch from F\/TDF to F\/TAF while maintaining the same third agent in the Spanish VACH cohort HIV","volume":"22","author":"Teira","year":"2021","journal-title":"Res Clin Pract."},{"key":"B8","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/S0140-6736(20)31065-5","article-title":"Emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV pre-exposure prophylaxis (DISCOVER): primary results from a randomised, double-blind, multicentre, active-controlled, phase 3, non-inferiority trial","volume":"396","author":"Mayer","year":"2020","journal-title":"Lancet."},{"key":"B9","doi-asserted-by":"publisher","first-page":"e0259168","DOI":"10.1371\/journal.pone.0259168","article-title":"HIV Pre-exposure prophylaxis (PrEP) purchase patterns and STI occurrence among Israeli men: a cohort analysis","volume":"16","author":"Chemtob","year":"2021","journal-title":"PLoS ONE."},{"key":"B10","doi-asserted-by":"publisher","first-page":"e0245925","DOI":"10.1371\/journal.pone.0245925","article-title":"Low use of condom and high STI incidence among men who have sex with men in PrEP programs","volume":"16","author":"Ayerdi Aguirrebengoa","year":"2021","journal-title":"PLoS ONE."},{"key":"B11","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1136\/sextrans-2021-055216","article-title":"Chemsex, sexual behaviour and STI-PrEP use among HIV-PrEP users during the COVID-19 pandemic in Brighton, UK","volume":"98","author":"Ringshall","year":"2022","journal-title":"Sex Transm Infect."},{"key":"B12","doi-asserted-by":"publisher","first-page":"e531","DOI":"10.1016\/S2352-3018(21)00108-9","article-title":"Epidemiology of anal human papillomavirus infection and high-grade squamous intraepithelial lesions in 29 900 men according to HIV status, sexuality, and age: a collaborative pooled analysis of 64 studies","volume":"8","author":"Wei","year":"2021","journal-title":"Lancet HIV."},{"key":"B13","doi-asserted-by":"publisher","first-page":"242","DOI":"10.17235\/reed.2017.4274\/2016","article-title":"Preliminary results of a screening program for anal cancer and its precursors for HIV-infected men who have sex with men in Vigo-Spain","volume":"109","author":"Iribarren D\u00edaz","year":"2017","journal-title":"Rev Espa\u00f1ol Enfermed Digest."},{"key":"B14","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1089\/lgbt.2020.0257","article-title":"Anal cancer screening for HIV-negative men who have sex with men: making clinical decisions with limited data","volume":"8","author":"Fuchs","year":"2021","journal-title":"LGBT Health."},{"key":"B15","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1001\/jama.2021.23487","article-title":"Diagnosis and treatment of sexually transmitted infections: a review","volume":"327","author":"Tuddenham","year":"2022","journal-title":"JAMA."},{"key":"B16","doi-asserted-by":"publisher","first-page":"e470","DOI":"10.1111\/jdv.15799","article-title":"Incidence of cutaneous adverse events after exposure to tenofovir\u2013emtricitabine in HIV-uninfected vs HIV-infected patients: pharmacovigilance within a large Midwestern U","volume":"33","author":"Kosche","year":"2019","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"3754","DOI":"10.1007\/s10461-021-03337-2","article-title":"Characterizing the impact of COVID-19 on pre-exposure prophylaxis (PrEP) care","volume":"25","author":"Rogers","year":"2021","journal-title":"AIDS Behav."},{"key":"B18","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1097\/QAI.0000000000002640","article-title":"Changes in sexual behavior, PrEP adherence, and access to sexual health services because of the COVID-19 pandemic among a cohort of PrEP-using MSM in the South","volume":"87","author":"Pampati","year":"2021","journal-title":"J Acquir Immune Defic Syndr 1988."},{"key":"B19","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1097\/OLQ.0000000000001506","article-title":"Trends in nationally notifiable sexually transmitted disease case reports during the US COVID-19 pandemic, January to December 2020","volume":"48","author":"Pagaoa","year":"2021","journal-title":"Sex Transm Dis."},{"key":"B20","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1089\/mdr.2020.0594","article-title":"Large increase in azithromycin-resistant neisseria gonorrhoeae in Northern Spain","volume":"28","author":"Carballo","year":"2022","journal-title":"Microb Drug Resist."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1001\/jama.2019.2947","article-title":"Association of HIV preexposure prophylaxis with incidence of sexually transmitted infections among individuals at high risk of HIV infection","volume":"321","author":"Traeger","year":"2019","journal-title":"JAMA."},{"key":"B22","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1097\/OLQ.0000000000000614","article-title":"New human immunodeficiency virus diagnosis independently associated with rectal gonorrhea and chlamydia in men who have sex with men","volume":"44","author":"Barbee","year":"2017","journal-title":"Sex Transm Dis."},{"key":"B23","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1093\/cid\/ciaa002","article-title":"Prevalence and incidence of human papillomavirus infection in men having sex with men enrolled in a pre-exposure prophylaxis study: a sub-study of the agence nationale de recherches sur le SIDA et les h\u00e9patites virales \u201cintervention pr\u00e9ventive de l'exposition aux risques avec et pour les hommes gays\u201d trial","volume":"72","author":"Cotte","year":"2021","journal-title":"Clin Infect Dis."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1016\/j.biopha.2018.06.149","article-title":"The human papillomavirus (HPV)-related cancer biology: an overview","volume":"106","author":"Araldi","year":"2018","journal-title":"Biomed Pharmacother."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.3390\/microorganisms10051047","article-title":"Update on the epidemiological features and clinical implications of human papillomavirus infection (HPV) and human immunodeficiency virus (HIV) coinfection","volume":"10","author":"P\u00e9rez-Gonz\u00e1lez","year":"2022","journal-title":"Microorganisms."},{"key":"B26","doi-asserted-by":"publisher","first-page":"e3474","DOI":"10.1590\/1518-8345.4975.3474","article-title":"Factors associated with chemsex in Portugal during the COVID-19 pandemic","volume":"29","author":"Chone","year":"2021","journal-title":"Rev Lat Am Enfermagem."},{"key":"B27","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.drugpo.2018.11.014","article-title":"Chemsex behaviours among men who have sex with men: a systematic review of the literature","volume":"63","author":"Maxwell","year":"2019","journal-title":"Int J Drug Policy."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.3390\/jcm10081662","article-title":"Chemsex practices and health-related quality of life in spanish men with hiv who have sex with men","volume":"10","author":"Ruiz-Robledillo","year":"2021","journal-title":"J Clin Med."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.eimc.2021.04.005","article-title":"Experiencia de un programa de profilaxis preexposici\u00f3n en una unidad de virus de la inmunodeficiencia humana hospitalaria. Descripci\u00f3n del perfil basal del usuario e identificaci\u00f3n de oportunidades de mejora","author":"Laguno","year":"2021","journal-title":"Enferm Infecc Microbiol Clin."},{"key":"B30","doi-asserted-by":"publisher","first-page":"13299","DOI":"10.3390\/ijerph182413299","article-title":"Mental health symptoms associated with sexualized drug use (Chemsex) among men who have sex with men: a systematic review","volume":"18","author":"\u00cdncera-Fern\u00e1ndez","year":"2021","journal-title":"Int J Environ Res Public Health."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2021-055215","article-title":"Chemsex and incidence of sexually transmitted infections among Canadian pre-exposure prophylaxis (PrEP) users in the l'Actuel PrEP Cohort (2013\u20132020)","author":"Flores Anato","year":"2022","journal-title":"Sex Transm Infect."},{"key":"B32","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s12981-018-0201-3","article-title":"Increases in condomless chemsex associated with HIV acquisition in MSM but not heterosexuals attending a HIV testing center in Antwerp, Belgium","volume":"15","author":"Kenyon","year":"2018","journal-title":"AIDS Res Ther."},{"key":"B33","doi-asserted-by":"publisher","first-page":"e69","DOI":"10.1097\/QAI.0000000000001781","article-title":"Is on-demand HIV pre-exposure prophylaxis a suitable tool for men who have sex with men who practice chemsex? Results from a substudy of the ANRS-IPERGAY","volume":"79","author":"Roux","year":"2018","journal-title":"Trial J Acquir Immune Defic Syndr."}],"container-title":["Frontiers in Public Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2022.1005622\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T07:20:39Z","timestamp":1666941639000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2022.1005622\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,28]]},"references-count":33,"alternative-id":["10.3389\/fpubh.2022.1005622"],"URL":"https:\/\/doi.org\/10.3389\/fpubh.2022.1005622","relation":{},"ISSN":["2296-2565"],"issn-type":[{"value":"2296-2565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,28]]},"article-number":"1005622"}}