{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:17:01Z","timestamp":1787318221323,"version":"build-2736575974"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:p>\n                    oXiris is a new, high-adsorption membrane filter in continuous hemofiltration adsorption to reduce the inflammatory response in sepsis. The investigators retrospectively reviewed patients with sepsis\/septic shock who underwent at least one oXiris-treatment from November 2020 to March 2022. The demographic data, baseline levels before treatment, clinical datas, prognosis, and the occurrence of adverse events during treatment were recorded. 90 patients were enrolled in this study. The hemodynamic indices, sequential organ failure assessment score, lactate, inflammatory biomarkers levels were significantly improved at 12 h and 24 h after treatment. Procalcitonin and interleukin-6 reduction post-treatment of oXiris were most pronounced in infection from skin and soft tissue, urinary and abdominal cavity. Logistic regression analysis showed that pre-treatment sequential organ failure assessment score (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.034), percentage decrease in sequential organ failure assessment score (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.004), and age (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.011) were independent risk factors for intensive care unit mortality. In conclusion, oXiris-continuous hemofiltration adsorption may improve hemodynamic indicators, reduce the use of vasoactive drugs, reduce lactate level and infection indicators. Of note, oXiris improve organ function in sepsis, which may result to higher survival rate.\n                  <\/jats:p>","DOI":"10.3389\/fpubh.2022.1012998","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T07:48:14Z","timestamp":1664437694000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Application of oXiris-continuous hemofiltration adsorption in patients with sepsis and septic shock: A single-centre experience in China"],"prefix":"10.3389","volume":"10","author":[{"given":"Yanyan","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenfang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingming","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxiu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA."},{"key":"B2","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s13054-019-2372-2","article-title":"Heterogeneity in sepsis: new biological evidence with clinical applications","volume":"23","author":"Leligdowicz","year":"2019","journal-title":"Crit Care."},{"key":"B3","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/s41392-021-00816-9","article-title":"Signaling pathways and intervention therapies in sepsis","volume":"6","author":"Zhang","year":"2021","journal-title":"Signal Transduct Target Ther."},{"key":"B4","doi-asserted-by":"publisher","first-page":"10238","DOI":"10.3390\/ijms221910238","article-title":"Renal replacement techniques in septic shock","volume":"22","author":"Hellman","year":"2021","journal-title":"Int J Mol Sci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s13613-020-0648-y","article-title":"Prescription of crrt: a pathway to optimize therapy","volume":"10","author":"Karkar","year":"2020","journal-title":"Ann Intensive Care."},{"key":"B6","doi-asserted-by":"publisher","first-page":"699418","DOI":"10.3389\/fbioe.2021.699418","article-title":"Advances in the development of biomaterials for endotoxin adsorption in sepsis","volume":"9","author":"Yang","year":"2021","journal-title":"Front Bioeng Biotechnol."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1159\/000499520","article-title":"Extracorporeal blood purification therapies for sepsis","author":"Monard","year":"2019","journal-title":"Blood Purif"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e0220444","DOI":"10.1371\/journal.pone.0220444","article-title":"Endotoxin and cytokine reducing properties of the oxiris membrane in patients with septic shock: a randomized crossover double-blind study","volume":"14","author":"Broman","year":"2019","journal-title":"PLoS ONE."},{"key":"B9","first-page":"3839","article-title":"The application value of oxiris-endotoxin adsorption in sepsis","volume":"13","author":"Zhai","year":"2021","journal-title":"Am J Transl Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"8157","DOI":"10.12998\/wjcc.v9.i27.8157","article-title":"Successful treatment of gastrointestinal infection-induced septic shock using the oxiris hemofilter: a case report","volume":"9","author":"Li","year":"2021","journal-title":"World J Clin Cases."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000499510","article-title":"Oxiris\u00ae use in septic shock: experience of two french centres","author":"Schwindenhammer","year":"2019","journal-title":"Blood Purif"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/kisup.2012.1","article-title":"Kidney disease: Improving global outcomes (KDIGO) acute kidney injury work group. 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