{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:25:32Z","timestamp":1780583132591,"version":"3.54.1"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Leukemia caused by occupational risk is a problem that needs more attention and remains to be solved urgently, especially for acute lymphoid leukemia (ALL), acute myeloid leukemia (AML), and chronic lymphoid leukemia (CLL). However, there is a paucity of literature on this issue. We aimed to assess the global burden and trends of leukemia attributable to occupational risk from 1990 to 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This observational trend study was based on the Global Burden of Disease (GBD) 2019 database, the global deaths, and disability-adjusted life years (DALYs), which were calculated to quantify the changing trend of leukemia attributable to occupational risk, were analyzed by age, year, geographical location, and socio-demographic index (SDI), and the corresponding estimated annual percentage change (EAPC) values were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Global age-standardized DALYs and death rates of leukemia attributable to occupational risk presented significantly decline trends with EAPC [\u22120.38% (95% CI: \u22120.58 to \u22120.18%) for DALYs and \u22120.30% (95% CI: \u22120.45 to \u22120.146%) for death]. However, it was significantly increased in people aged 65\u201369 years [0.42% (95% CI: 0.30\u20130.55%) for DALYs and 0.38% (95% CI: 0.26\u20130.51%) for death]. At the same time, the age-standardized DALYs and death rates of ALL, AML, and CLL were presented a significantly increased trend with EAPCs [0.78% (95% CI: 0.65\u20130.91%), 0.87% (95% CI: 0.81\u20130.93%), and 0.66% (95% CI: 0.51\u20130.81%) for DALYs, respectively, and 0.75% (95% CI: 0.68\u20130.82%), 0.96% (95% CI: 0.91\u20131.01%), and 0.55% (95% CI: 0.43\u20130.68%) for death], respectively. The ALL, AML, and CLL were shown an upward trend in almost all age groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We observed a substantial reduction in leukemia due to occupational risks between 1990 and 2019. However, the people aged 65\u201369 years and burdens of ALL, AML, and CLL had a significantly increased trend in almost all age groups. Thus, there remains an urgent need to accelerate efforts to reduce leukemia attributable to occupational risk-related death burden in this population and specific causes.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2022.1015861","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T14:37:05Z","timestamp":1668436625000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Global disease burden and trends of leukemia attributable to occupational risk from 1990 to 2019: An observational trend 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