{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:01:35Z","timestamp":1791414095736,"version":"4.3.3"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T00:00:00Z","timestamp":1666224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:p>Cognitive decline is a gradual neurodegenerative process that is affected by genetic and environmental factors. The doctor-patient relationship in the healthcare for cognitive decline is in a \u201cshallow\u201d medical world. With the development of data science, virtual reality, artificial intelligence, and digital twin, the introduction of the concept of the metaverse in medicine has brought alternative and complementary strategies in the intervention of cognitive decline. This article technically analyzes the application scenarios and paradigms of the metaverse in medicine in the field of mental health, such as hospital management, diagnosis, prediction, prevention, rehabilitation, progression delay, assisting life, companionship, and supervision. The metaverse in medicine has made primary progress in education, immersive consultation, dental disease, and Parkinson's disease, bringing revolutionary prospects for non-pharmacological complementary treatment of cognitive decline and other mental problems. In particular, with the demand for non-face-to-face communication generated by the global COVID-19 epidemic, the needs for uncontactable healthcare service for the elderly have increased. The paradigm of self-monitoring, self-healing, and healthcare experienced by the elderly through the metaverse in medicine, especially from meta-platform, meta-community, and meta-hospital, will be generated, which will reconstruct the service modes for the elderly people. The future map of the metaverse in medicine is huge, which depends on the co-construction of community partners.<\/jats:p>","DOI":"10.3389\/fpubh.2022.1016680","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T08:27:50Z","timestamp":1666254470000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":30,"title":["The paradigm and future value of the metaverse for the intervention of cognitive decline"],"prefix":"10.3389","volume":"10","author":[{"given":"Hao","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Yi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"10470","DOI":"10.26355\/eurrev_201912_19686","article-title":"Ambient assisted living technologies for older adults with cognitive and physical impairments: a review","volume":"23","author":"Ganesan","year":"2019","journal-title":"Eur Rev Med Pharmacol Sci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.cell.2021.12.041","article-title":"Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration","volume":"185","author":"Tracy","year":"2022","journal-title":"Cell"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12546","article-title":"APP accumulates with presynaptic proteins around amyloid plaques: a role for presynaptic mechanisms in Alzheimer's disease?","author":"Jord\u00e0-Siquier","year":"2022","journal-title":"Alzheimers Dement."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12553","article-title":"Endotype reversal as a novel strategy for screening drugs targeting familial Alzheimer's disease","author":"Caldwell","year":"2022","journal-title":"Alzheimers Dement."},{"key":"B5","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/s41746-019-0191-0","article-title":"Artificial intelligence for precision medicine in neurodevelopmental disorders","volume":"2","author":"Uddin","year":"2019","journal-title":"NPJ Digit Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ceh.2022.02.001","article-title":"Expert consensus on the metaverse in medicine","volume":"5","author":"Yang","year":"2022","journal-title":"Clin eHealth"},{"key":"B7","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3352\/jeehp.2021.18.32","article-title":"Educational applications of metaverse: possibilities and limitations","volume":"18","author":"Kye","year":"2021","journal-title":"J Educ Eval Health Prof."},{"key":"B8","doi-asserted-by":"publisher","first-page":"103383","DOI":"10.1016\/j.jbi.2020.103383","article-title":"Internet of things in medicine: A systematic mapping study","volume":"103","author":"Sadoughi","year":"2020","journal-title":"J Biomed Inform."},{"key":"B9","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.parkreldis.2021.03.032","article-title":"Uptake of telehealth in Parkinson's disease clinical care and research during the COVID-19 pandemic","volume":"86","author":"Shivkumar","year":"2021","journal-title":"Parkinsonism Relat Disord"},{"key":"B10","doi-asserted-by":"publisher","first-page":"110241","DOI":"10.1016\/j.ejrad.2022.110241","article-title":"The use of metaverse in fetal medicine and gynecology","volume":"150","author":"Werner","year":"2022","journal-title":"Eur J Radiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/s41415-022-3990-7","article-title":"Dental education in the metaverse","volume":"232","author":"Locurcio","year":"2022","journal-title":"Br Dent J."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3352\/jeehp.2022.19.2","article-title":"Application of computer-based testing in the Korean medical licensing examination, the emergence of the metaverse in medical education, journal metrics and statistics and statistics, and appreciation to reviewers and volunteers","volume":"19","author":"Huh","year":"2022","journal-title":"J Educ Eval Health Prof."},{"key":"B13","doi-asserted-by":"publisher","first-page":"745","DOI":"10.3390\/jpm11080745","article-title":"Digital twins: from personalised medicine to precision public health","volume":"11","author":"Kamel Boulos","year":"2021","journal-title":"J Pers Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.3390\/diagnostics11112032","article-title":"Can autism be diagnosed with artificial intelligence? 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