{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T10:35:42Z","timestamp":1766486142280,"version":"3.41.2"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T00:00:00Z","timestamp":1664928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Obese or overweight is a risk factor for some chronic diseases, and oxidative stress and inflammation may be one of the molecular mechanisms leading to the persistence of these chronic diseases. Discovering interventions to alleviate oxidative stress and inflammation in the overweight\/obese population, is very important for public health and health education.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A two-week panel intervention study (Run 0-Run 1-Run 2) was conducted. The subjects were 77 overweight\/obese undergraduates attending Dali University, with a BMI&amp;gt;24 kg\/m<jats:sup>2<\/jats:sup>. The physical indices measured at the end of each run included BMI, waist circumference, serum ROS, TNF-\u03b1, IL-1\u03b2 and urinary 8-OHdG. Students were allocated to one of four intervention groups: No intervention (control); walking; taking vitamin C; and walking + taking vitamin C.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results demonstrated (1) Walking significantly alleviated ROS levels, and this was consistent in Run 1 and Run 2; (2) During Run1, all three intervention modes reduced levels of 8-OHdG, but there was a statistically insignificant increase during Run 2; (3) No alleviating effects of the three intervention modes on TNF-\u03b1 levels during Run 1 and Run 2 were observed; (4) The alleviating effects of the three intervention modes on IL-1\u03b2 levels during Run 1 and Run 2 were clear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Walking and taking vitamin C can reduce levels of ROS, 8-OHdG and IL-1\u03b2, but not TNF-\u03b1, in overweight\/obese participants. These interventions may become potential preventive measures for the overweight against obese-induced oxidative stress and inflammation.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2022.1024864","type":"journal-article","created":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T06:50:02Z","timestamp":1664952602000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Walking and taking vitamin C alleviates oxidative stress and inflammation in overweight students, even in the short-term"],"prefix":"10.3389","volume":"10","author":[{"given":"Qian","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huizhi","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianwen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuohui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"She","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,5]]},"reference":[{"journal-title":"The Affluent Society, 4th ed.","year":"1984","author":"Galbraith","key":"B1"},{"journal-title":"Metabolic Syndrome and Cardiovascular Disease. 1st ed","year":"2010","author":"Levine","key":"B2"},{"key":"B3","doi-asserted-by":"publisher","first-page":"853","DOI":"10.19540\/j.cnki.cjcmm.20210929.601","article-title":"A key issue of China national health: Excess energy intake and oxidative inflammation","volume":"47","author":"Xiao","year":"2021","journal-title":"China J Chin Materia Medica."},{"key":"B4","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1038\/ejcn.2012.17","article-title":"Proinflammatory and oxidative stress markers in patients submitted to Roux-en-Y gastric bypass after 1 year of follow-up","volume":"66","author":"Da Silva","year":"2012","journal-title":"Eu J Clin Nutri."},{"key":"B5","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.jada.2011.02.003","article-title":"Vitamin C status is related to proinflammatory responses and impaired vascular endothelial function in healthy, college-aged lean and obese men","volume":"111","author":"Mah","year":"2011","journal-title":"J Am Dietetic Association"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1038\/sj.ejcn.1601667","article-title":"C-reactive protein concentration and concentrations of blood vitamins, carotenoids, and selenium among United States adults","volume":"57","author":"Ford","year":"2003","journal-title":"Eu J Clin Nutri."},{"key":"B7","doi-asserted-by":"publisher","first-page":"3205","DOI":"10.1182\/blood.V99.9.3205","article-title":"B\u00f3rquez-Ojeda Oriana, Golde David W. Vitamin C inhibits granulocyte macrophage-colony-stimulating factor-induced signaling pathways","volume":"99","author":"C\u00e1rcamo","year":"2002","journal-title":"Blood."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1021\/jf3007008","article-title":"Mitigation of inflammation with foods","volume":"60","author":"Wu","year":"2012","journal-title":"J Agri Food Chem"},{"journal-title":"Dietary Guidelines for Chinese Residents","year":"2016","author":"Chinese","key":"B9"},{"key":"B10","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3390\/nu11010023","article-title":"Inflammation and oxidative stress in an obese state and the protective effects of Gallic acid","volume":"11","author":"Dludla","year":"2019","journal-title":"Nutrients."},{"key":"B11","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1152\/physiolgenomics.00114.2017","article-title":"Gut microbiome may contribute to insulin resistance and systemic inflammation in obese rodents: a meta-analysis","volume":"50","author":"Jiao","year":"2018","journal-title":"Physiol Genomics."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.3390\/nu10091199","article-title":"Metabolically healthy versus unhealthy morbidly obese chronic inflammation, nitro-oxidative stress, and insulin resistance","volume":"10","author":"Catoi","year":"2018","journal-title":"Nutrients."},{"key":"B13","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.ebiom.2018.03.004","article-title":"Inflammatory cytokine profiles in visceral and subcutaneous adipose tissues of obese patients undergoing bariatric surgery reveal lack of correlation with obesity or diabetes","volume":"30","author":"Rakotoarivelo","year":"2018","journal-title":"EBioMedicine."},{"key":"B14","doi-asserted-by":"publisher","first-page":"751","DOI":"10.4103\/ijem.IJEM_206_18","article-title":"Evaluation of proinflammatory cytokines in obese vs. non-obese patients with metabolic syndrome","volume":"22","author":"Ashral","year":"2018","journal-title":"IJEM."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/GME.0000000000001207","article-title":"Effect of high-intensity interval training on body composition and inflammatory markers in obese postmenopausal women: a randomized controlled trial","volume":"26","author":"Nunes","year":"2019","journal-title":"Menopause."},{"key":"B16","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1002\/ptr.6370","article-title":"Effects of curcumin supplementation on markers of inflammation and oxidative stress among healthy overweight and obese girl adolescents: a randomized placebo-controlled clinical trial","volume":"1","author":"Saraf-Bank","year":"2019","journal-title":"Phytother Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3390\/biomedicines8050123","article-title":"Low-grade inflammation is not present in former obese males but adipose tissue macrophage infiltration persists","volume":"8","author":"Ara","year":"2020","journal-title":"Biomedicines."},{"key":"B18","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1684\/ecn.2018.0415","article-title":"Obesity and inflammation","volume":"29","author":"Karczewski","year":"2019","journal-title":"Eur Cytokine Netw."},{"key":"B19","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.37358\/RC.19.6.7314","article-title":"The evaluation of oxidative stress levels in obesity","volume":"70","author":"Epingeac","year":"2019","journal-title":"Rev Chim-Bucharest."},{"key":"B20","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1038\/s41398-018-0303-7","article-title":"Obesity, altered oxidative stress, and clinical correlates in chronic schizophrenia patients","volume":"8","author":"An","year":"2018","journal-title":"Transl Psychiat."},{"key":"B21","doi-asserted-by":"publisher","first-page":"S109","DOI":"10.1016\/j.ypmed.2011.12.026","article-title":"Diets rich in fruits and vegetables suppress blood biomarkers of metabolic stress in overweight women","volume":"54","author":"Yeon","year":"2012","journal-title":"Prev Med."},{"key":"B22","doi-asserted-by":"publisher","first-page":"366","DOI":"10.46389\/rjd-2020.1053","article-title":"Serum levels of 8-hydroxy 2-deoxyguuanosine as a marker of DNA damage in healthy obese individuals","volume":"27","author":"Mohieldein","year":"2020","journal-title":"Rom J Diabetes Nutr Metab Dis."},{"key":"B23","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.chemosphere.2018.10.090","article-title":"The occurrence of bisphenol plasticizers in paired dust and urine samples and its association with oxidative stress","volume":"216","author":"Liu","year":"2019","journal-title":"Chemosphere."},{"key":"B24","doi-asserted-by":"publisher","first-page":"548","DOI":"10.3390\/jcm9020548","article-title":"Dysfunction of salivary glands, disturbances in salivary antioxidants and increased oxidative damage in saliva of overweight and obese adolescents","volume":"9","author":"Zalewska","year":"2020","journal-title":"J Clin Med."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1111\/j.1742-1241.2008.01789.x","article-title":"Modulating an oxidative-inflammatory cascade: potential new treatment strategy for improving glucose metabolism, insulin resistance, and vascular function","volume":"62","author":"Lamb","year":"2008","journal-title":"Int J Clin Pract."},{"key":"B26","first-page":"1949","article-title":"Therapeutic effect of Moringa Oleifera leaf extracts on oxidative stress and key metabolic enzymes related to obesity","volume":"11","author":"Swamy","year":"2020","journal-title":"Int J Pharm Sci Res."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/vms3.478","article-title":"Impact of high dietary energy on obesity and oxidative stress in domestic pigeons","volume":"3","author":"Hosseinian","year":"2021","journal-title":"Vet Med Sci"},{"key":"B28","doi-asserted-by":"publisher","first-page":"174377","DOI":"10.1016\/j.ejphar.2021.174377","article-title":"Timosaponin alleviates oxidative stress in rats with high fat diet-induced obesity via activating Nrf2\/HO-1 and inhibiting the NF-\u03baB pathway","volume":"909","author":"Liu","year":"2021","journal-title":"Eur J Pharmacol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/2048004016633371","article-title":"clinical perspective of obesity, metabolic syndrome and cardiovascular disease","volume":"5","author":"Han","year":"2016","journal-title":"J Roy Soc Med Cardiovasc Dis."},{"key":"B30","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.diabres.2014.04.006","article-title":"Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes","volume":"105","author":"Esser","year":"2014","journal-title":"Diabetes Res Clin Pr."},{"key":"B31","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.pcad.2011.03.013","article-title":"Exercise in obesity, metabolic syndrome, and diabetes","volume":"53","author":"Church","year":"2011","journal-title":"Prog Cardiovasc Dis."},{"key":"B32","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.metabol.2012.08.012","article-title":"The complex interaction between obesity, metabolic syndrome and reproductive axis: a narrative review","volume":"62","author":"Michalakis","year":"2013","journal-title":"Metabolism."},{"key":"B33","doi-asserted-by":"publisher","first-page":"212","DOI":"10.23736\/S0026-4806.17.05022-4","article-title":"Obesity and cardiovascular diseases","volume":"108","author":"Kachur","year":"2017","journal-title":"Minerva Med."},{"key":"B34","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.pcad.2018.07.003","article-title":"An overview and update on obesity and the obesity paradox in cardiovascular diseases","volume":"61","author":"Elagizi","year":"2018","journal-title":"Prog Cardiovasc Dis."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1161\/CIRCRESAHA.120.316101","article-title":"Obesity phenotypes, diabetes, and cardiovascular diseases","volume":"126","author":"Pich\u00e9","year":"2020","journal-title":"Circ Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s00592-010-0187-3","article-title":"Epidemiological aspects of neoplasms in diabetes","volume":"47","author":"Nicolucci","year":"2010","journal-title":"Acta Diabetol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1186\/1471-2458-12-440","article-title":"The costs of overweight and obesity-related diseases in the Brazilian public health system: cross-sectional study","volume":"12","author":"Bahia","year":"2012","journal-title":"BMC Public Health."},{"key":"B38","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1002\/hep.27172","article-title":"Obesity and hepatocellular carcinoma: Hype and reality","volume":"60","author":"El-Serag","year":"2014","journal-title":"Hepatology."},{"key":"B39","doi-asserted-by":"publisher","first-page":"S1332","DOI":"10.21037\/jtd.2018.02.66","article-title":"Nutritional status and muscle dysfunction in chronic respiratory diseases: stable phase versus acute exacerbations","volume":"10","author":"Gea","year":"2018","journal-title":"J Thorac Dis."},{"key":"B40","doi-asserted-by":"publisher","first-page":"210","DOI":"10.4187\/respcare.03467","article-title":"Trends in prevalence and prognosis in subjects with acute chronic respiratory failure treated with noninvasive and\/or invasive ventilation","volume":"60","author":"Gacouin","year":"2015","journal-title":"Resp Care."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1080\/10408398.2017.1404442","article-title":"Obesity and neurological disorders: Dietary perspective of a global menace","volume":"59","author":"Bhat","year":"2019","journal-title":"Crit Rev Food Sci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/S1474-4422(17)30084-4","article-title":"Neurological consequences of obesity","volume":"16","author":"O'Brien","year":"2017","journal-title":"Lancet Neurol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1111\/nyas.13542","article-title":"Updates on obesity pharmacotherapy","volume":"1411","author":"Velazquez","year":"2018","journal-title":"Ann NY Acad Sci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1007\/s00018-011-0840-1","article-title":"Metabolic syndrome as a risk factor for neurological disorders","volume":"69","author":"Farooqui","year":"2012","journal-title":"Cell Mol Life Sci."},{"key":"B45","doi-asserted-by":"publisher","first-page":"241","DOI":"10.4239\/wjd.v10.i4.241","article-title":"Risk factors in patients with type 2 diabetes in Bengaluru: A retrospective study","volume":"10","author":"Aravinda","year":"2019","journal-title":"World J Diabetes."},{"key":"B46","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1126\/science.1104342","article-title":"How obesity causes diabetes: Not a tall tale","volume":"5708","author":"Lazar","year":"2005","journal-title":"Science."},{"key":"B47","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1038\/s41581-019-0145-4","article-title":"do Carmo JM, da Silva AA, Wang Z, Hall ME","volume":"15","author":"Hall","year":"2019","journal-title":"Obesity, kidney dysfunction and hypertension: mechanistic links Nat Rev Nephrol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"e69391","DOI":"10.5812\/compreped.69391","article-title":"Correlation between urinary tract and kidney diseases in pediatrics with obesity","volume":"10","author":"Rezagholizamnjany","year":"2019","journal-title":"J Compr Ped."},{"key":"B49","unstructured":"GBD Compare|VizHub"},{"key":"B50","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1042\/bj3530411","article-title":"Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space","volume":"353","author":"Han","year":"2001","journal-title":"Biochem J."}],"container-title":["Frontiers in Public Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2022.1024864\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T06:50:09Z","timestamp":1664952609000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2022.1024864\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,5]]},"references-count":50,"alternative-id":["10.3389\/fpubh.2022.1024864"],"URL":"https:\/\/doi.org\/10.3389\/fpubh.2022.1024864","relation":{},"ISSN":["2296-2565"],"issn-type":[{"type":"electronic","value":"2296-2565"}],"subject":[],"published":{"date-parts":[[2022,10,5]]},"article-number":"1024864"}}