{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T15:10:48Z","timestamp":1780758648097,"version":"3.54.1"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T00:00:00Z","timestamp":1670544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the prevalence of adverse pregnancy outcomes (APOs) in women and the impact of pre-pregnancy couples' genital <jats:italic>Chlamydia Trachomatis<\/jats:italic> (GCT) infection and other infections on APOs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>Data on genital infections were collected from the Free Pre-pregnancy Health Check (FPHC) in Shenzhen, China. Data on APOs were collected from a 1-year telephone follow-up of pregnancy status and subsequent pregnancy outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>APO data were used to count adverse outcomes, and logistic regression was conducted to determine the association between APOs and GCT infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From December 2018 to December 2019, among 4,429 couples who underwent FPHC; 1,925 were pregnant, and 1,816 couples were tracked for pregnancy outcomes, including 1,471 normal pregnancies and 345 (19.00%) APOs. The rest of 109 pregnant couples did not answer the phone or refused to answer the pregnancy outcome during the follow-up. Among APOs, the number of spontaneous abortions was 122 (35.36%), the number of macrosomia was 85 (24.64%), the number of low birth weight (LBW) &amp;amp; preterm births (PTB) was 39 (11.30%), the number of LBW was 34 (9.86%), and the number of PTB was 31 (8.99%). The prevalence of GCT infection in females and males was 4.24% [95% Confidence Interval, (CI): 3.41\u20135.27%] and 3.58% (95% CI: 2.79\u20134.57%), respectively. More than half (52.69%, 49\/93) of the couples were GCT-concordant. The prevalence of APOs in couples without GCT infection was 18.74% (332\/1,772). The prevalence of APOs in female GCT-discordant was 32.14% (9\/28), and the prevalence of APOs in male GCT-discordant was 25% (4\/16). The prevalence of APOs in GCT-concordant was 12.24% (6\/49). Multivariable analysis indicated that females 30\u201335 years old [adjusted Odds Ratio (aOR) = 1.08, 95% CI: 1.01\u20131.17] and over 35 years old (aOR = 1.16, 95% CI: 1.03\u20131.32) were more likely to experiencing APOs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although only women's age was found to be associated with APOs, the prevalence of APOs with GCT-discordant in couples, especially female GCT-discordant, was higher than in those without infection or who were GCT-concordant, suggesting that these groups, especially in older women, should be paid more attention to in follow-ups to improve reproductive health.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2022.1038391","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T05:34:21Z","timestamp":1670564061000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["The association between adverse 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