{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:28:22Z","timestamp":1753892902596,"version":"3.41.2"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T00:00:00Z","timestamp":1668470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Human adenovirus (HAdV) coinfection with other respiratory viruses is common, but adenovirus infection combined with human coronavirus-229E (HCoV-229E) is very rare.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design and setting<\/jats:title><jats:p>Clinical manifestations, laboratory examinations, and disease severity were compared between three groups: one coinfected with HAdV-Ad7 and HCoV-229E, one infected only with adenovirus (mono-adenovirus), and one infected only with HCoV-229E (mono-HCoV-229E).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From July to August 2019, there were 24 hospitalized children: two were coinfected with HAdV-Ad7 and HCoV-229E, and 21 were infected with a single adenovirus infection. Finally, one 14-year-old boy presented with a high fever, but tested negative for HAdV-Ad7 and HCoV-229E. Additionally, three adult asymptotic cases with HCoV-229E were screened. No significant difference in age was found in the coinfection and mono-adenovirus groups (11 vs. 8 years, <jats:italic>p<\/jats:italic> = 0.332). Both groups had the same incubation period (2.5 vs. 3 days, <jats:italic>p<\/jats:italic> = 0.8302), fever duration (2.5 vs. 2.9 days, <jats:italic>p<\/jats:italic> = 0.5062), and length of hospital stay (7 vs. 6.76 days, <jats:italic>p<\/jats:italic> = 0.640). No obvious differences were found in viral loads between the coinfection and mono-adenovirus groups (25.4 vs. 23.7, <jats:italic>p<\/jats:italic> = 0.570), or in the coinfection and mono-HCoV-229E groups (32.9 vs. 30.06, <jats:italic>p<\/jats:italic> = 0.067). All cases recovered and were discharged from the hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HAdV-Ad7 and HCoV-229E coinfection in healthy children may not increase the clinical severity or prolong the clinical course. The specific interaction mechanism between the viruses requires further study.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2022.1048108","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T09:06:40Z","timestamp":1668503200000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The clinical and virological features of two children's coinfections with human adenovirus type 7 and human coronavirus-229E 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