{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T07:24:02Z","timestamp":1767597842837,"version":"3.41.2"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Presently, the omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) dominates amid the coronavirus disease 2019 (COVID-19) pandemic, but its clinical characteristics with intrinsic severity and organ tropism remain understudied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reported 1,001 mild COVID-19 patients that were infected with the omicron variant of SARS-CoV-2 and hospitalized in China from February to June 2022, including their demographic information, medical\/immunization history, clinical symptom, and hematological profile. Patients with one-, two- and three-dose vaccination were compared to assess the vaccine effectiveness. Importantly, liver damage caused by the omicron variant infection was evaluated, in comparison to that caused by the wild-type or the delta variant SARS-CoV-2 infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For the reported COVID-19 patients infected by the omicron variant of SARS-CoV-2, their median age was 36.0 [interquartile range (IQR): 26.0-50.0] and 49.7% were female. Hypertension, diabetes, and bronchitis were the leading comorbidities, and asymptomatic patients took up a major portion (61.2%). While most hematological parameters revealed the alleviated pathogenicity, full vaccination or booster shot showed effective protection against clinical severity. Furthermore, liver damages caused by viral infection of the omicron variant were largely attenuated when compared to those by infection of the wild-type or the delta variant SARS-CoV-2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results supported that the viremic effect of the omicron variant tended to be modest, while the liver damage caused by this strain became milder than the previous circulating variants.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2022.1049006","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T06:44:02Z","timestamp":1668753842000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Hepatic dysfunctions in COVID-19 patients infected by the omicron variant of SARS-CoV-2"],"prefix":"10.3389","volume":"10","author":[{"given":"Jianguo","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daguo","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhui","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingqing","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhimin","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/s41586-020-2008-3","article-title":"New coronavirus associated with human respiratory disease in China","volume":"579","author":"Wu","year":"2020","journal-title":"Nature"},{"key":"B2","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","article-title":"Pneumonia outbreak associated with a new coronavirus of probable bat origin","volume":"579","author":"Zhou","year":"2020","journal-title":"Nature."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1001\/jama.2020.1585","article-title":"Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China","volume":"323","author":"Wang","year":"2020","journal-title":"JAMA."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study","volume":"395","author":"Zhou","year":"2020","journal-title":"Lancet."},{"key":"B5","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1038\/s41581-021-00452-0","article-title":"Pathophysiology of COVID-19-associated acute kidney injury","volume":"17","author":"Legrand","year":"2021","journal-title":"Nat Rev Nephrol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2851","DOI":"10.1681\/ASN.2021060734","article-title":"Kidney outcomes in long COVID","volume":"32","author":"Bowe","year":"2021","journal-title":"J Am Soc Nephrol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/s41591-022-01689-3","article-title":"Long-term cardiovascular outcomes of COVID-19","volume":"28","author":"Xie","year":"2022","journal-title":"Nat Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/s4157.-022-00607-9","article-title":"COVID-19 and liver disease: where are we now?","volume":"19","author":"Russo","year":"2022","journal-title":"Nat Rev Gastroenterol Hepatol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1002\/hep.31487","article-title":"Abnormal liver tests in COVID-19: a retrospective observational cohort study of 1,827 patients in a major US hospital network","volume":"72","author":"Hundt","year":"2020","journal-title":"Hepatology."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1002\/hep.31480","article-title":"Abnormal liver function tests in patients with COVID-19: relevance and potential pathogenesis","volume":"72","author":"Bertolini","year":"2020","journal-title":"Hepatology"},{"key":"B11","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.jhep.2020.04.006","article-title":"COVID-19: abnormal liver function tests","volume":"73","author":"Cai","year":"2020","journal-title":"J Hepatol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.humpath.2020.11.015","article-title":"Pathological findings in the postmortem liver of patients with coronavirus disease 2019 (COVID-19)","volume":"109","author":"Zhao","year":"2021","journal-title":"Hum Pathol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"2518","DOI":"10.1001\/jama.2020.8907","article-title":"Postmortem examination of patients with COVID-19","volume":"323","author":"Schaller","year":"2020","journal-title":"J Am Med Assoc."},{"key":"B14","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1038\/d41586-021-03846-z","article-title":"Activity of convalescent and vaccine serum against SARS-CoV-2 omicron","volume":"602","author":"Carre\u00f1o","year":"2022","journal-title":"Nature."},{"key":"B15","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/s41586-021-04388-0","article-title":"Striking antibody evasion manifested by the omicron variant of SARS-CoV-2","volume":"602","author":"Liu","year":"2022","journal-title":"Nature."},{"key":"B16","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/s41586-021-04389-z","article-title":"Considerable escape of SARS-CoV-2 omicron to antibody neutralization","volume":"602","author":"Planas","year":"2022","journal-title":"Nature."},{"key":"B17","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1038\/s41586-021-04385-3","article-title":"Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies","volume":"602","author":"Cao","year":"2022","journal-title":"Nature."},{"key":"B18","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s40164-021-00228-z","article-title":"Platelet-driven coagulopathy in COVID-19 patients: in comparison to seasonal influenza cases","volume":"10","author":"Zhang","year":"2021","journal-title":"Exp Hematol Oncol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1002\/hcs2.1","article-title":"Diagnosis and treatment protocol for COVID-19 patients (trial version 9)","volume":"1","year":"2020","journal-title":"Health Care Sci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"293","DOI":"10.46234\/ccdcw2022.074","article-title":"Association of COVID-19 vaccination and clinical severity of patients infected with delta or omicron variants\u2014China, May 21, 2021\u2013February 28, 2022","volume":"4","author":"Li","year":"2022","journal-title":"China CDC Weekly."},{"key":"B21","doi-asserted-by":"publisher","first-page":"e15179","DOI":"10.7759\/cureus.15179","article-title":"Model of end-stage liver disease (MELD) score as a predictor of in-hospital mortality in patients with COVID-19: a novel approach to a classic scoring system","volume":"13","author":"Stawinski","year":"2021","journal-title":"Cureus."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1080\/21505594.2021.1909894","article-title":"High Child-Pugh and CRUB65 scores predict mortality of decompensated cirrhosis patients with COVID-19: a 23-center, retrospective study","volume":"12","author":"Xiao","year":"2021","journal-title":"Virulence."},{"key":"B23","doi-asserted-by":"publisher","first-page":"e594","DOI":"10.1093\/cid\/ciaa1710","article-title":"Early elevation of fibrosis-4 liver fibrosis score is associated with adverse outcomes among patients with coronavirus disease 2019","volume":"73","author":"Xiang","year":"2021","journal-title":"Clin Infect Dis"},{"key":"B24","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1002\/hep4.1650","article-title":"Liver fibrosis index FIB-4 is associated with mortality in COVID-19","volume":"5","author":"Li","year":"2021","journal-title":"Hepatol Commun."},{"key":"B25","doi-asserted-by":"publisher","first-page":"829423","DOI":"10.3389\/fmed.2022.829423","article-title":"Liver fibrosis scores and clinical outcomes in patients with COVID-19","volume":"9","author":"Zhang","year":"2022","journal-title":"Front Med."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1002\/hep4.1745","article-title":"Impact of COVID-19 in liver disease progression","volume":"5","author":"Martinez","year":"2021","journal-title":"Hepatol Commun."},{"key":"B27","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/s41575-021-00426-4","article-title":"COVID-19 and liver disease: mechanistic and clinical perspectives","volume":"18","author":"Marjot","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.1001\/jama.2020.6775","article-title":"Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area","volume":"323","author":"Richardson","year":"2020","journal-title":"JAMA"},{"key":"B29","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1002\/hep.31301","article-title":"Longitudinal association between markers of liver injury and mortality in COVID-19 in China","volume":"72","author":"Lei","year":"2020","journal-title":"Hepatology."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical characteristics of coronavirus disease 2019 in China","volume":"382","author":"Guan","year":"2020","journal-title":"New Eng J Med."},{"key":"B31","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s40249-020-00662-x","article-title":"Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues","volume":"9","author":"Li","year":"2020","journal-title":"Infect Dis Pov."},{"key":"B32","doi-asserted-by":"publisher","first-page":"e9610","DOI":"10.15252\/msb.20209610","article-title":"The protein expression profile of ACE2 in human tissues","volume":"16","author":"Hikmet","year":"2020","journal-title":"Mol Syst Biol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"2038","DOI":"10.1111\/liv.14500","article-title":"SARS-CoV-2 virus and liver expression of host receptors: Putative mechanisms of liver involvement in COVID-19","volume":"40","author":"Pirola","year":"2020","journal-title":"Liver Int."},{"key":"B34","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.jhep.2020.05.002","article-title":"SARS-CoV-2 infection of the liver directly contributes to hepatic impairment in patients with COVID-19","volume":"73","author":"Wang","year":"2020","journal-title":"J Hepatol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2110","DOI":"10.1111\/liv.14601","article-title":"Liver histopathology in severe COVID 19 respiratory failure is suggestive of vascular alterations","volume":"40","author":"Sonzogni","year":"2020","journal-title":"Liver Int."},{"key":"B36","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/s42255-022-00552-6","article-title":"Molecular consequences of SARS-CoV-2 liver tropism","volume":"4","author":"Wanner","year":"2022","journal-title":"Nat Metab."},{"key":"B37","doi-asserted-by":"publisher","first-page":"eabe4724","DOI":"10.1126\/sciadv.abe4724","article-title":"JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality","volume":"7","author":"Stebbing","year":"2021","journal-title":"Sci Adv."},{"key":"B38","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1136\/gutjnl-2021-324280","article-title":"B, et al. Residual SARS-CoV-2 viral antigens detected in GI and hepatic tissues from five recovered patients with COVID-19","volume":"71","author":"Cheung","year":"2022","journal-title":"Gut."},{"key":"B39","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1002\/hep4.1843","article-title":"Covid-19 and liver injury: role of inflammatory endotheliopathy, platelet dysfunction, and thrombosis","volume":"6","author":"McConnell","year":"2022","journal-title":"Hepatol Commun."},{"key":"B40","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/S2213-2600(20)30243-5","article-title":"Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans","volume":"8","author":"Fox","year":"2020","journal-title":"Lancet Respir Med."},{"key":"B41","doi-asserted-by":"publisher","first-page":"100330","DOI":"10.1093\/ndt\/gfac063.002","article-title":"First report from the German COVID-19 autopsy registry","volume":"15","author":"von Stillfried","year":"2022","journal-title":"Lancet Reg Health Eur."},{"key":"B42","doi-asserted-by":"publisher","first-page":"e108","DOI":"10.1097\/PG9.0000000000000108","article-title":"Acute liver failure in a healthy young female with COVID-19","volume":"2","author":"Orandi","year":"2021","journal-title":"JPGN Rep."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1136\/gutjnl-2020-321350","article-title":"Severe liver failure during SARS-CoV-2 infection","volume":"69","author":"Weber","year":"2020","journal-title":"Gut."},{"key":"B44","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/S2213-2600(22)00126-6","article-title":"Health outcomes in people 2 years after surviving hospitalisation with COVID-19: a longitudinal cohort study","volume":"10","author":"Huang","year":"2022","journal-title":"Lancet Respir Med"},{"key":"B45","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1186\/s12876-021-01939-7","article-title":"Intriguing findings of liver fibrosis following COVID-19","volume":"21","author":"Kolesova","year":"2021","journal-title":"BMC Gastroenterol."},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2024815118","article-title":"The total number and mass of SARS-CoV-2 virions","author":"Sender","year":"2021","journal-title":"Proc Natl Acad Sci USA."},{"key":"B47","doi-asserted-by":"publisher","first-page":"3675","DOI":"10.1128\/JVI.80.7.3675-3678.2006","article-title":"Comparison of the mutation rates of human influenza A and B viruses","volume":"80","author":"Nobusawa","year":"2006","journal-title":"J Virol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1471-2148-4-21","article-title":"Moderate mutation rate in the SARS coronavirus genome and its implications","volume":"4","author":"Zhao","year":"2004","journal-title":"BMC Evol Biol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1016\/S0140-6736(13)61887-5","article-title":"Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study","volume":"382","author":"Cotten","year":"2013","journal-title":"Lancet."},{"key":"B50","doi-asserted-by":"publisher","first-page":"veab020","DOI":"10.1093\/ve\/veab020","article-title":"The evolutionary dynamics of endemic human coronaviruses","volume":"7","author":"Jo","year":"2021","journal-title":"Vir Evol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1261\/rna.079160.122","article-title":"Rampant C-to-U deamination accounts for the intrinsically high mutation rate in SARS-CoV-2 spike gene","volume":"28","author":"Liu","year":"2022","journal-title":"RNA."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1126\/science.abm1208","article-title":"Analysis of 6, 4 million SARS-CoV-2 genomes identifies mutations associated with fitness","volume":"376","author":"Obermeyer","year":"2022","journal-title":"Science."},{"key":"B53","doi-asserted-by":"publisher","first-page":"2560","DOI":"10.1038\/s41467-022-30163-4","article-title":"Cumulative SARS-CoV-2 mutations and corresponding changes in immunity in an immunocompromised patient indicate viral evolution within the host","volume":"13","author":"Sonnleitner","year":"2022","journal-title":"Nat Commun."},{"key":"B54","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1038\/s41392-022-00992-2","article-title":"Tracking SARS-CoV-2 omicron diverse spike gene mutations identifies multiple inter-variant recombination events","volume":"7","author":"Ou","year":"2022","journal-title":"Signal Trans Targ Ther."},{"key":"B55","doi-asserted-by":"publisher","first-page":"e02077","DOI":"10.1128\/jvi.02077-21","article-title":"Omicron: What makes the latest SARS-CoV-2 variant of concern so concerning?","volume":"96","author":"Jung","year":"2022","journal-title":"J Virol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1001\/jama.2021.24868","article-title":"Characteristics and outcomes of hospitalized patients in South Africa during the COVID-19 omicron wave compared with previous waves","volume":"327","author":"Maslo","year":"2022","journal-title":"JAMA."},{"key":"B57","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/S0140-6736(22)00017-4","article-title":"Early assessment of the clinical severity of the SARS-CoV-2 omicron variant in South Africa: a data linkage study","volume":"399","author":"Wolter","year":"2022","journal-title":"Lancet."},{"key":"B58","doi-asserted-by":"publisher","first-page":"831","DOI":"10.7326\/P22-0005","article-title":"Comparison of patients infected with delta vs. omicron COVID-19 variants presenting to paris emergency departments : a retrospective cohort study","volume":"175","author":"Bouzid","year":"2022","journal-title":"Ann Int Med."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1056\/NEJMoa2119658","article-title":"Population immunity and Covid-19 severity with omicron variant in South Africa","volume":"386","author":"Madhi","year":"2022","journal-title":"New Eng J Med."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1016\/S0140-6736(22)00462-7","article-title":"Comparative analysis of the risks of hospitalisation and death associated with SARS-CoV-2 omicron (B1, 1529) and delta (B16172) variants in England: a cohort study","volume":"399","author":"Nyberg","year":"2022","journal-title":"Lancet."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1016\/S0140-6736(22)00327-0","article-title":"Symptom prevalence, duration, and risk of hospital admission in individuals infected with SARS-CoV-2 during periods of omicron and delta variant dominance: a prospective observational study from the ZOE COVID study","volume":"399","author":"Menni","year":"2022","journal-title":"Lancet."},{"key":"B62","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41586-022-04442-5","article-title":"Attenuated replication and pathogenicity of SARS-CoV-2 B11529 omicron","volume":"603","author":"Shuai","year":"2022","journal-title":"Nature."},{"key":"B63","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1038\/s41586-022-04474-x","article-title":"Altered TMPRSS2 usage by SARS-CoV-2 omicron impacts infectivity and fusogenicity","volume":"603","author":"Meng","year":"2022","journal-title":"Nature."},{"key":"B64","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/s41586-022-04462-1","article-title":"The Genotype to Phenotype Japan, Attenuated fusogenicity and pathogenicity of SARS-CoV-2 omicron variant","volume":"603","author":"Suzuki","year":"2022","journal-title":"Nature."},{"key":"B65","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41392-022-00903-5","article-title":"Omicron adopts a different strategy from Delta and other variants to adapt to host","volume":"7","author":"Du","year":"2022","journal-title":"Signal Transd Targ Ther."},{"key":"B66","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1053\/j.gastro.2022.04.043","article-title":"Reduced replication efficacy of severe acute respiratory syndrome coronavirus 2 omicron variant in \u201cMini-gut\u201d organoids","volume":"163","author":"Miyakawa","year":"2022","journal-title":"Gastroenterology."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1097\/MEG.0000000000002381","article-title":"Clinical features and predictive factors related to liver injury in SARS-CoV-2 delta and omicron variant-infected patients","volume":"10","author":"Deng","year":"9900","journal-title":"Eur J Gastroenterol Hepatol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/s41421-022-00418-x","article-title":"Proteomic characterization of omicron SARS-CoV-2 host response","volume":"8","author":"Bao","year":"2022","journal-title":"Cell Discov."},{"key":"B69","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.ijid.2022.05.028","article-title":"High population burden of omicron variant (B.1.1.529) is associated with the emergence of severe hepatitis of unknown etiology in children","volume":"122","author":"Nishiura","year":"2022","journal-title":"Int J Infect Dis."},{"key":"B70","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/S2468-1253(22)00166-2","article-title":"Severe acute hepatitis in children: investigate SARS-CoV-2 superantigens","volume":"7","author":"Brodin","year":"2022","journal-title":"Lancet Gastroenterol Hepatol."}],"container-title":["Frontiers in Public Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2022.1049006\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T06:44:04Z","timestamp":1668753844000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2022.1049006\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,18]]},"references-count":70,"alternative-id":["10.3389\/fpubh.2022.1049006"],"URL":"https:\/\/doi.org\/10.3389\/fpubh.2022.1049006","relation":{},"ISSN":["2296-2565"],"issn-type":[{"type":"electronic","value":"2296-2565"}],"subject":[],"published":{"date-parts":[[2022,11,18]]},"article-number":"1049006"}}