{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T08:32:40Z","timestamp":1787819560682,"version":"build-2784847793"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:p>Reliable disinfection and sterilization technologies are needed to deal with the various infectious diseases spreading around the world. Furthermore, bacteria that are difficult to eliminate by ordinary disinfection are also a problem in the medical environment. We examined the germicidal effect of a newly developed deep-ultraviolet light-emitting diode (DUV-LED) prototype device (wavelength of 280 \u00b1 5 nm; power of 0.9 to 1.4 mW\/cm<jats:sup>2<\/jats:sup>) for floor sterilization against <jats:italic>Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), Mycobacterium gordonae (M. gordonae)<\/jats:italic>, and <jats:italic>Bacillus subtilis (B. subtilis)<\/jats:italic>. This prototype device is equipped with highly practical DUV-LEDs with a high output efficiency and a long life, and was designed with consideration of the irradiation distance and the angle of the DUV-LEDs to provide a uniform irradiation rate. We found a statistically significant reduction of \u226590% in the infectious titers of both <jats:italic>E. coli<\/jats:italic> and <jats:italic>S. aureus<\/jats:italic> after irradiation for 2 s. Although acid-fast bacilli and spore-type bacilli are generally thought to be resistant to UV light irradiation compared to general bacteria, the acid-fast bacillus <jats:italic>M. gordonae<\/jats:italic> was inactivated after irradiation for 10 s, and spore-type cells of the bacillus <jats:italic>B. subtilis<\/jats:italic> were inactivated by \u226590% after irradiation for 30 s. We also found that the effects were cumulative when irradiation was performed at intervals. In the future, the usefulness of this device as an infection control measure will be evaluated in daily medical practice.<\/jats:p>","DOI":"10.3389\/fpubh.2022.1053729","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T07:22:10Z","timestamp":1670224930000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Usefulness of a new DUV-LED device for the control of infection by Escherichia coli, Staphylococcus aureus, mycobacteria and spore-forming bacteria"],"prefix":"10.3389","volume":"10","author":[{"given":"Hiroko","family":"Inagaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Goto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironobu","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akatsuki","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamaki","family":"Okabayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyosuke","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouichi","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.cej.2018.03.020","article-title":"Microorganisms inactivation by continuous and pulsed irradiation of ultraviolet light-emitting diodes (UV-LEDs)","volume":"343","author":"Song","year":"2018","journal-title":"Chem Eng J."},{"key":"B2","doi-asserted-by":"publisher","first-page":"114965","DOI":"10.1016\/j.watres.2019.114965","article-title":"Pulsed and continuous light UV LED: microbial inactivation, electrical, and time efficiency","volume":"165","author":"Sholtes","year":"2019","journal-title":"Water Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"3411","DOI":"10.1038\/s41598-020-60459-8","article-title":"Inactivation of Listeria and E coli by Deep-UV LED: effect of substrate conditions on inactivation kinetics","volume":"10","author":"Cheng","year":"2020","journal-title":"Sci Rep."},{"key":"B4","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.watres.2017.11.047","article-title":"Inactivation kinetics and efficiencies of UV-LEDs against Pseudomonas aeruginosa, Legionella pneumophila, and surrogate microorganisms","volume":"130","author":"Rattanakul","year":"2018","journal-title":"Water Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"e00944","DOI":"10.1128\/AEM.00944-18","article-title":"UVC LED irradiation effectively inactivates aerosolized viruses, bacteria, and fungi in a chamber-type air disinfection system","volume":"84","author":"Kim","year":"2018","journal-title":"Appl Environ Microbiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"3438","DOI":"10.1002\/jmv.27698","article-title":"Rapid inactivation of Dabie bandavirus (SFTSV) by irradiation with deep-ultraviolet light-emitting diode","volume":"94","author":"Kaneko","year":"2022","journal-title":"J Med Virol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1080\/22221751.2020.1796529","article-title":"Rapid inactivation of SARS-CoV-2 with deep-UV LED irradiation","volume":"9","author":"Inagaki","year":"2020","journal-title":"Emerg Microbes Infect."},{"key":"B8","doi-asserted-by":"publisher","first-page":"754","DOI":"10.3390\/pathogens10060754","article-title":"Rapid inactivation of SARS-CoV-2 variants by continuous and intermittent irradiation with a deep-ultraviolet light-emitting diode (DUV-LED) Device","volume":"10","author":"Inagaki","year":"2021","journal-title":"Pathogens."},{"key":"B9","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1002\/(SICI)1097-0010(20000501)80:6&lt;637::AID-JSFA603&gt;3.0.CO;2-1","article-title":"Existing and potential applications of ultraviolet light in the food industry\u2014A critical review","volume":"80","author":"Bintsis","year":"2000","journal-title":"J. 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