{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T03:12:12Z","timestamp":1778296332709,"version":"3.51.4"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T00:00:00Z","timestamp":1671667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>Preeclampsia is a serious multisystem blood pressure disorder during pregnancy that is associated with increased long-term risk of cardiovascular disease to the mother and offspring. We investigated the vascular health of children exposed to intrauterine preeclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>This was a cross-sectional study of offspring in a prospective cohort of women with complications during pregnancy. Children aged between 2 and 5 years [median age 4.7 (2.8, 5.1) years] exposed to intrauterine preeclampsia (<jats:italic>n<\/jats:italic> = 26) or normotensive controls (<jats:italic>n<\/jats:italic> = 34), were recruited between July 2020 and April 2021. Vascular health was assessed by measuring aortic intima-media thickness and pulse wave velocity. Univariate generalized linear regression models were used to explore associations between vascular measurements and explanatory variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Children exposed to preeclampsia had a lower body mass index at assessment (15.5 vs. 16.2 kg\/m<jats:sup>2<\/jats:sup>, <jats:italic>p<\/jats:italic> = 0.04), birth weight (2.90 vs. 3.34 kg, <jats:italic>p<\/jats:italic> = 0.004), gestational age at birth (37.5 vs. 39.4 weeks, <jats:italic>p<\/jats:italic> &amp;lt; 0.001) and higher frequency of preterm birth (27% vs. 6%, <jats:italic>p<\/jats:italic> = 0.02). There were no differences in vascular health between children exposed to preeclampsia vs. controls (mean aortic intima-media thickness 0.575 mm vs. 0.563 mm, <jats:italic>p<\/jats:italic> = 0.51, pulse wave velocity 4.09 vs. 4.18 m\/s, <jats:italic>p<\/jats:italic> = 0.54) and there were no significant associations in univariate analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There were no major adverse differences in vascular health which contrasts with existing studies. This suggests exposure to intrauterine preeclampsia may result in a less severe cardiovascular phenotype in young children. While reassuring, longitudinal studies are required to determine if and when exposure to intrauterine preeclampsia affects vascular health in children.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2022.1071304","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T11:06:47Z","timestamp":1671707207000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Intrauterine exposure to preeclampsia does not impair vascular health in children"],"prefix":"10.3389","volume":"10","author":[{"given":"Benjamin 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