{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T15:17:42Z","timestamp":1786375062458,"version":"build-2736575974"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T00:00:00Z","timestamp":1643932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Diabetic renal fibrosis (DRF) is an irreversible renal pathological change in the end-stage of diabetic kidney disease (DKD), which plays a significant role in the development and deterioration of the disease. However, data for bibliometric analysis of renal fibrosis in DKD is currently missing. This study aimed to provide a comprehensive and visualized view of DRF research and lay the foundation for further studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Firstly, the data was collected from the Web of Science Core Collection (WoSCC) database. Secondly, the Web of Science analytic tool was performed to analyze publication years, authors, countries\/regions, organizations, and citation frequency. Finally, CiteSpace was employed to construct a visualization bibliometric network to reveal the emerging trends and hotspots of DRF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 3,821 publications from 1985 to 2020 were included in this study. The number of publications has maintained a growth trend since 2003. Cooper is the most prolific author in this field, and the <jats:italic>American Journal of Physiology-Renal Physiology<\/jats:italic> ranking as first place compared with other journals. In terms of the number of publications, China contributed the most to DRF. Monash University is the organization that published the most papers. The top 5 clusters of keyword co-appearance are \u201cchronic kidney disease\u201d, \u201cprimary biliary cirrhosis\u201d, \u201creceptor\u201d, \u201cTGF-beta\u201d, \u201crenal tubulointerstitium\u201d. The top 5 clusters of reference co-citation are \u201cmicroRNAs\u201d, \u201cbone morphogenetic protein\u201d, \u201chypertrophy\u201d, \u201cglomerulosclerosis\u201d, \u201cdiabetic kidney disease\u201d. The strongest citation burst of keyword is \u201cdiabetic kidney disease\u201d and the strongest burst of cited reference is \u201cMeng, 2016\u201d.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study analyzed the research hotspots, Frontiers, and development trend of DRF and have important implications for future research.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2022.767591","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T04:56:55Z","timestamp":1643950615000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Bibliometric Analysis of Renal Fibrosis in Diabetic Kidney Disease From 1985 to 2020"],"prefix":"10.3389","volume":"10","author":[{"given":"Yuqing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyun","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengmei","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"7242384","DOI":"10.1155\/2017\/7242384","article-title":"Role of epigenetic histone modifications in diabetic kidney disease involving renal fibrosis","volume":"2017","author":"Sun","year":"2017","journal-title":"J Diabetes Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1038\/nrneph.2011.149","article-title":"Cellular and molecular mechanisms of renal fibrosis","volume":"7","author":"Liu","year":"2011","journal-title":"Nat Rev Nephrol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.jfma.2018.02.007","article-title":"Update of pathophysiology and management of diabetic kidney disease","volume":"117","author":"Lin","year":"2018","journal-title":"J Formos Med Assoc."},{"key":"B4","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/978-981-13-8871-2_12","article-title":"Myofibroblast in kidney fibrosis: origin, activation, and regulation","volume":"1165","author":"Yuan","year":"2019","journal-title":"Adv Exp Med Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1016\/s0002-9440(10)62533-3","article-title":"Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis","volume":"159","author":"Yang","year":"2001","journal-title":"Am J Pathol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1146\/annurev-physiol-022516-034227","article-title":"Mechanisms of renal fibrosis","volume":"80","author":"Humphreys","year":"2018","journal-title":"Annu Rev Physiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2760","DOI":"10.2337\/dc20-0630","article-title":"Profibrotic circulating proteins and risk of early progressive renal decline in patients with type 2 diabetes with and without albuminuria","volume":"43","author":"Ihara","year":"2020","journal-title":"Diabetes Care."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1111\/jcmm.13060","article-title":"Signalling pathways involved in hypoxia-induced renal fibrosis","volume":"21","author":"Liu","year":"2017","journal-title":"J Cell Mol Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/s0344-0338(11)80780-6","article-title":"The pathogenesis of chronic renal failure in diabetic nephropathy. 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