{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:22:10Z","timestamp":1790994130567,"version":"4.1.0"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T00:00:00Z","timestamp":1647475200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the eye-related quality of life (ER-QOL), functional vision, and their determinants in children following congenital and developmental cataract surgery, as the impact on their families, using the Pediatric Eye Questionnaire (PedEyeQ).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This was a retrospective cross-sectional study involving 107 children (aged 0\u201311 years) with congenital and developmental cataracts who had undergone surgery, as well as 59 visually healthy controls (aged 0\u201311 years). One parent for each child completed either the Proxy 0\u20134 PedEyeQ, the Proxy 5\u201311 PedEyeQ, or the Parent PedEyeQ, depending on their child's age. Mann-Whitney U and Kruskal-Wallis tests were then conducted to compare the differences between groups and to analyze their determinants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PedEyeQ scores were found to be lower in postoperative children with congenital and developmental cataracts compared with the control group across all study domains. The PedEyeQ Proxy 0 to 4 years' greatest mean difference was 27 points worse in the Functional Vision domain (95% CI \u221234 to \u221219; <jats:italic>p<\/jats:italic> &amp;lt; 0.001). We also found that the occurrence of nystagmus (<jats:italic>p<\/jats:italic> &amp;lt; 0.005) and strabismus (<jats:italic>p<\/jats:italic> &amp;lt; 0.005) were the major factors affecting participants' functional vision. The PedEyeQ Proxy 5 to 11 years' greatest mean difference was 23 points worse in this same domain (95% CI \u221230 to \u221215; <jats:italic>p<\/jats:italic> &amp;lt; 0.001), with nystagmus (<jats:italic>p<\/jats:italic> &amp;lt; 0.05) being the main determinant herein. Parent PedEyeQ 0 to 4 years' greatest difference was 46 points worse on the Worry about their Child's Eye Condition domain (95% CI \u221257 to \u221236; <jats:italic>p<\/jats:italic> &amp;lt; 0.001). Similarly, parents of children with ophthalmologic abnormalities, including nystagmus (<jats:italic>p<\/jats:italic> &amp;lt; 0.001) and strabismus (<jats:italic>p<\/jats:italic> &amp;lt; 0.05), were significantly more worried about their children's eye condition. Parent PedEyeQ 5 to 11 years' greatest difference was also found to be 30 points worse on the Worry about their Child's Eye Condition domain (95% CI \u221243 to \u221217; <jats:italic>p<\/jats:italic> &amp;lt; 0.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Children who have undergone congenital and developmental cataract surgery experience a lower quality of life and reduced functional vision. Their families are also significantly and adversely affected herein. Thus, more attention is needed on these groups, with more focused measures being administered to both children and their families.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2022.788384","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T05:54:30Z","timestamp":1647496470000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["A Retrospective Study on the Eye-Related Quality of Life, Functional Vision, and Their Determinants Among Children Following Congenital and Developmental Cataracts Surgery and Its Impact on Their Families Using the 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