{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:03:41Z","timestamp":1792047821387,"version":"4.4.0"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:00:00Z","timestamp":1649635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Syndecan-1 (SDC-1) has been shown to have a high predictive value for sepsis development, though uncertainty around these results exists. The aim of this meta-analysis was to assess the prognostic ability of SDC-1 in predicting sepsis-related complications and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed, EMBASE, Cochrane Library, and Google Scholar databases from January 01, 1990, to March 17, 2021, to identify eligible studies. The search terms used were \u201cSDC-1,\u201d \u201csepsis,\u201d \u201csevere sepsis,\u201d and \u201cseptic shock,\u201d and a meta-analysis was performed using the RevMan 5.4 software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eleven studies with a total of 2,318 enrolled patients were included. SDC-1 concentrations were significantly higher in the composite poor outcome group [standardized mean difference (SMD) = 0.55; 95% CI: 0.38\u20130.72;\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001] as well as in deceased patients (SMD = 0.53; 95% CI: 0.40\u20130.67;\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001), patients with septic shock (SMD = 0.81; 95% CI: 0.36\u20131.25;\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001), and patients with acute kidney injury (SMD = 0.48; 95% CI: 0.33\u20130.62;\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001). Statistical significance was also found in the subgroup analysis when stratified by different sepsis diagnostic criteria.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Baseline SDC-1 levels may be a useful predictor of sepsis-related complications and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic Review Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?ID=CRD42021246344<\/jats:ext-link>\n                      , PROSPERO, identifier: CRD42021246344.\n                    <\/jats:p>\n                  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