{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:14:47Z","timestamp":1787163287912,"version":"build-2736575974"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T00:00:00Z","timestamp":1655164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:p>\n                    The present interventional study aimed to assess the impact of micronutrient supplementation on pesticide-residues concentrations, vitamins, minerals, acetylcholinesterase activity and oxidative stress among 129 farm children (9\u201312 years,\n                    <jats:italic>n<\/jats:italic>\n                    = 66 and 13\u201315 years,\n                    <jats:italic>n<\/jats:italic>\n                    = 63) involved in farming activities in Ranga Reddy district, Telangana, India. Our data showed the presence of five organophosphorus pesticide residues (chlorpyrifos, diazinon, malathion, monocrotophos, and phosalone) among children before-supplementation (both age-groups); while post-supplementation, only two pesticide residues (chlorpyrifos and diazinon) were detected indicating improved metabolic rate. Vitamin E, copper, magnesium and zinc levels were also improved in both the age-groups and manganese levels were significantly increased only among children of 13\u201315 years age group. Further, post-supplementation also showed an improvement in acetylcholinesterase activity and a decrease in lipid peroxidation among both the age groups of children. However, further research for ascertaining the ameliorating effect of micronutrients in preventing adverse effects of organophosphorus pesticides must be conducted.\n                  <\/jats:p>","DOI":"10.3389\/fpubh.2022.872125","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T01:45:50Z","timestamp":1655171150000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Impact of Micronutrient Supplementation on Pesticide Residual, Acetylcholinesterase Activity, and Oxidative Stress Among Farm Children Exposed to Pesticides"],"prefix":"10.3389","volume":"10","author":[{"given":"Srujana","family":"Medithi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogeswar Dayal","family":"Kasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay Radhakrishna","family":"Kankipati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkaiah","family":"Kodali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babban","family":"Jee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padmaja R.","family":"Jonnalagadda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1007\/s12291-012-0207-x","article-title":"Effect of vitamin E supplementation on biochemical parameters in pesticides sprayers of grape gardens of Western Maharashtra (India)","author":"Patil","year":"2012","journal-title":"Indian J Clin Biochem 27."},{"key":"B2","doi-asserted-by":"crossref","DOI":"10.1093\/jn\/137.12.2794","article-title":"Interactions between nutrition and environmental exposures: effects on health outcomes in women and children","author":"Kordas","year":"2007"},{"key":"B3","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1080\/19338244.2020.1750333","article-title":"Predominant role of antioxidants in ameliorating the oxidative stress induced by pesticides","volume":"76","author":"Medithi","year":"2020","journal-title":"Arch Environ Occup Health"},{"key":"B4","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1007\/s002040100219","article-title":"In vivo changes in antioxidant systems and protective role of melatonin and a combination of vit C and E on oxidative damage in erythrocytes induced by chlorpyrifos-ethyl in rats","volume":"75","author":"Gultekin","year":"2001","journal-title":"Arch Toxicol."},{"key":"B5","unstructured":"Alteration of biochemical parameters after supplementation of multivitamins and minerals of sprayers on grape gardens of Western Maharashtra (India)4551\n            PatilJA\n            ArunAJ\n            SontakkeAV\n            SanjayP\n          Al Ameen J Med Sci.72014"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1016\/j.fct.2009.04.018","article-title":"Methiocarb-induced oxidative damage following sub-acute exposure and the protective effects of vitamin E and taurine in rats","volume":"47","author":"Ozden","year":"2009","journal-title":"Food Chem Toxicol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.pestbp.2009.08.004","article-title":"Comparative studies on Chlorpyrifos and methyl parathion induced oxidative stress in different parts of rat brain: attenuation by antioxidant vitamin","volume":"95","author":"Verma","year":"2009","journal-title":"Pesticide Biochem Physiol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.pestbp.2009.08.008","article-title":"Oxidative damage, biochemical and histopathological alterations in rats exposed to Chlorpyrifos and the antioxidant role of zinc","volume":"96","author":"Mansour","year":"2010","journal-title":"Pesticide Biochem. 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