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Public Health"],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>HIV epidemiology in South-Central China is rarely reported. This study aims to characterize epidemiological and clinical features of HIV-infected patients in Hunan Province, located in South-Central China, for better management of HIV infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study retrieved multi-center records of laboratory-confirmed HIV-infected patients in Hunan province. Information on HIV-associated mortality and antiretroviral therapies was also collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 34,297 patients diagnosed with HIV infections from 2003 to 2018, 73.9% were males, 41.3% were older adults (\u226550 years), and 71.2% were infected by heterosexual transmission. Despite a slow growth of new HIV infections in the overall population, annual percentages of HIV infections increased in older males (85.3% through heterosexual transmission) and young patients &amp;lt;30 years (39.9% through homosexual transmission). At baseline, serum levels of CD4+ T-cell counts were lower in older adults (191.0 cells\/\u03bcl) than in young patients (294.6 cells\/\u03bcl, <jats:italic>p<\/jats:italic>-value &amp;lt; 0.0001). A large proportion (47.2%, <jats:italic>N<\/jats:italic> = 16,165) of HIV-infected patients had advanced HIV disease (CD4+ T-cell counts &amp;lt; 200 cells\/\u03bcl) from 2003 to 2018. All-cause mortality (57.0% due to AIDS-related illnesses) was reported among 4411 HIV-infected patients, including 2619 older adults. The 10-year survival rate was significantly lower in elderly males than in other patients (59.0 vs. 78.4%, <jats:italic>p<\/jats:italic>-value &amp;lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Elderly males are prone to HIV infections with a high risk of HIV-associated fatality. Our findings support early prevention and critical care for elderly populations to control HIV infections.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2022.902537","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T06:27:46Z","timestamp":1654756066000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Epidemiology and Clinical Outcomes of HIV Infection in South-Central China: A Retrospective Study From 2003 to 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