{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:59:53Z","timestamp":1777514393367,"version":"3.51.4"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T00:00:00Z","timestamp":1654214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Acute gastroenteritis is an important and highly prevalent public health problem worldwide. The purpose of this study was to assess the economic burden of disease and its influencing factors in patients with acute gastroenteritis in Heilongjiang Province, China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multi-stage stratified random sampling method was used in a face-to-face household survey in 2018. Demographic and socioeconomic characteristics, clinical symptoms, suspicious dietary history, and disease treatment information were collected from 19,647 respondents. One-way analysis of variance and multiple stepwise regression analysis were used to investigate the factors associated with the economic burden of acute gastroenteritis. Quantitative risk analysis and sensitivity analysis were performed to estimate the uncertainty and risk factors of the economic burden of acute gastroenteritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total economic burden of patients with acute gastroenteritis was 63,969.22 CNY (Chinese Yuan), of which the direct economic burden accounted for 63.82%; the per capita economic burden was 131.35 CNY per month. Age, region, disease duration, and disease treatment were the main factors significantly associated with the economic burden of acute gastroenteritis (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). The average economic burden of patients with acute gastroenteritis was approximately 571.84 CNY\/person (95% CI: 227\u20131,459). Sensitivity analysis showed that the greatest impact was from the indirect economic burden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Acute gastroenteritis brings a substantial health burden to patients due to its high incidence. The economic burden of self-purchased drugs and the indirect economic burden of patients cannot be ignored. To better estimate the economic burden of acute gastroenteritis in China, further studies on the pathogen-specific economic burden of acute gastroenteritis are required.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2022.905458","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T06:21:03Z","timestamp":1654237263000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Economic Burden and Influencing Factors of Acute Gastroenteritis in China: A Population-Based Face to Face Survey in 2018"],"prefix":"10.3389","volume":"10","author":[{"given":"Yue","family":"Huo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongwei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangru","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baiyang","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"104607","DOI":"10.1016\/j.meegid.2020.104607","article-title":"FilmArray GI-panel performance for the rapid and multiple detection of gastrointestinal microorganisms in foodborne illness outbreaks in Shenzhen during 2018-2019","volume":"86","author":"Hu","year":"2020","journal-title":"Infect Genet Evol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.medmal.2005.08.007","article-title":"Morbidity and cost of rotavirus infections in France","volume":"35","author":"Melliez","year":"2005","journal-title":"M\u00e9decine Mal Infect."},{"key":"B3","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1017\/S0950268803001559","article-title":"Costs of gastroenteritis in The Netherlands","volume":"132","author":"van den Brandhof","year":"2004","journal-title":"Epidemiol Infect."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1016\/S0140-6736(17)32130-X","article-title":"Global, regional, and national Disability-Adjusted Life-Years (DALYs) for 333 diseases and injuries and Healthy Life Expectancy (HALE) for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"90","author":"Hay","year":"2017","journal-title":"Lancet."},{"key":"B5","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3201\/eid1701.P21101","article-title":"Foodborne illness acquired in the United States-unspecified agents","volume":"17","author":"Scallan","year":"2011","journal-title":"Emerg Infect Dis."},{"key":"B6","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1017\/S0950268806006765","article-title":"population-based estimate of the substantial burden of diarrhoeal disease in the United States; FoodNet, 1996\u20132003","volume":"135","author":"Jones","year":"2007","journal-title":"Epidemiol Infect."},{"key":"B7","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1017\/S0950268812001331","article-title":"Population-based estimate of the burden of acute gastrointestinal illness in Jiangsu province, China, 2010-2011","volume":"141","author":"Zhou YJ Dai","year":"2013","journal-title":"Epidemiol Infect."},{"key":"B8","first-page":"35","article-title":"Analysis of food safety problems caused by foodborne diseases","volume":"35","author":"Zhao G","year":"2013","journal-title":"Trans Innov Sci Technol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.4161\/hv.28704","article-title":"Burden of acute gastroenteritis, norovirus and rotavirus in a managed care population","volume":"10","author":"Karve","year":"2014","journal-title":"Hum Vaccin Immunother."},{"key":"B10","doi-asserted-by":"publisher","first-page":"e146","DOI":"10.1017\/S095026881900044X","article-title":"The health and economic impact of acute gastroenteritis in Belgium, 2010-2014","volume":"147","author":"Papadopoulos","year":"2019","journal-title":"Epidemiol Infect."},{"key":"B11","doi-asserted-by":"publisher","first-page":"e0195759","DOI":"10.1371\/journal.pone.0195759","article-title":"Cost of gastroenteritis in Australia: a healthcare perspective","volume":"13","author":"Barker","year":"2018","journal-title":"PLoS ONE."},{"key":"B12","doi-asserted-by":"publisher","first-page":"6","DOI":"10.13590\/j.cjfh.2021.04.013","article-title":"Burden assessment of acute gastroenteritis among community population in Jiaxing from 2018 to 2019","volume":"33","author":"Lin","year":"2021","journal-title":"J Food Safe."},{"key":"B13","doi-asserted-by":"publisher","first-page":"e281","DOI":"10.3346\/jkms.2020.35.e281","article-title":"An outbreak associated with Sapovirus GI3 in an elementary school in Gyeonggi-do, Korea","volume":"35","author":"Cho","year":"2020","journal-title":"J Korean Med Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1017\/S0950268807009375","article-title":"A common, symptom-based case definition for gastroenteritis","volume":"136","author":"Majowicz","year":"2008","journal-title":"Epidemiol Infect."},{"key":"B15","doi-asserted-by":"publisher","first-page":"327","DOI":"10.3350\/cmh.2014.20.4.327","article-title":"Cost-of-illness studies: concepts, scopes, and methods","volume":"20","author":"Jo","year":"2014","journal-title":"Clin Mol Hepatol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.9734\/ajpas\/2019\/v5i230132","article-title":"Diagnosing multicollinearity of logistic regression model","volume":"5","author":"Senaviratna","year":"2019","journal-title":"Asian J Probab."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1186\/s12889-021-11240-7","article-title":"Analysis of the current status and associated factors of tuberculosis knowledge, attitudes, and practices among elderly people in Shenzhen: a cross-sectional study","volume":"21","author":"Wang","year":"2021","journal-title":"BMC Public Health."},{"key":"B18","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1080\/13696998.2020.1737534","article-title":"Economic burden of needlestick injuries among healthcare workers in China","volume":"23","author":"Zhang","year":"2020","journal-title":"J Med Econ."},{"key":"B19","doi-asserted-by":"publisher","first-page":"e0003547","DOI":"10.1371\/journal.pntd.0003547","article-title":"Economic and disease burden of dengue in Mexico","volume":"9","author":"Undurraga","year":"2015","journal-title":"PLoS Negl Trop Dis."},{"key":"B20","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.meddos.2021.02.003","article-title":"Mean parotid dose prediction model using machine learning regression method for intensity-modulated radiotherapy in head and neck cancer","volume":"46","author":"Ranjith","year":"2021","journal-title":"Med Dosim."},{"key":"B21","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1017\/S0950268811000999","article-title":"Burden of acute gastroenteritis and healthcare-seeking behaviour in France: a population-based study","volume":"140","author":"Cauteren","year":"2012","journal-title":"Epidemiol Infect."},{"key":"B22","doi-asserted-by":"publisher","first-page":"589","DOI":"10.19813\/j.cnki.weishengyanjiu.2019.04.008","article-title":"Preliminary estimating the burden of foodborne acute gastrointestinal illness in Beijing City","volume":"48","author":"Ma","year":"2019","journal-title":"J hygiene research."},{"key":"B23","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1007\/BF03403685","article-title":"Estimating the under-reporting rate for infectious gastrointestinal illness in Ontario","volume":"96","author":"Majowicz","year":"2005","journal-title":"Can J Public Health."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1136\/bmj.318.7190.1046","article-title":"Study of infectious intestinal disease in England: rates in the community, presenting to general practice, and reported to national surveillance","volume":"318","author":"Wheeler","year":"1999","journal-title":"BMJ."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1016\/S1473-3099(18)30362-1","article-title":"Estimates of the global, regional, and national morbidity, mortality, and aetiologies of diarrhoea in 195 countries: a systematic analysis for the Global Burden of Disease Study 2016","volume":"18","author":"GBD","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"B26","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.envint.2018.08.014","article-title":"Associations of Salmonella hospitalizations with ambient temperature, humidity and rainfall in Hong Kong","volume":"120","author":"Wang","year":"2018","journal-title":"Environ Int."},{"key":"B27","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1186\/1471-2458-13-456","article-title":"Burden of self-reported acute gastrointestinal illness in China: a population-based survey","volume":"13","author":"Chen","year":"2013","journal-title":"BMC Public Health."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1017\/S0950268811002020","article-title":"The burden of self-reported acute gastrointestinal illness in Italy: a retrospective survey, 2008-2009","volume":"140","author":"Scavia","year":"2012","journal-title":"Epidemiol Infect."},{"key":"B29","first-page":"81","article-title":"Population-based estimates of acute gastrointestinal and foodborne illness in Barbados: a retrospective cross-sectional study","volume":"31","author":"Ingram","year":"2013","journal-title":"J Health Popul Nutr."},{"key":"B30","doi-asserted-by":"publisher","first-page":"207","DOI":"10.13481\/j.1671-587x.20150241","article-title":"Assessment of hospital visiting situation and disease burden of patients with foodborne diseases in Jilin Province","volume":"41","author":"Liu","year":"2015","journal-title":"J Jilin Univ (Med ed)"},{"key":"B31","first-page":"3806","article-title":"Multi-factor analysis of the disease burden and its risk factors among diarrhea patients in Guangxi","author":"Lin","year":"2009","journal-title":"Prev Med"}],"container-title":["Frontiers in Public Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2022.905458\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T16:00:45Z","timestamp":1655136045000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2022.905458\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,3]]},"references-count":31,"alternative-id":["10.3389\/fpubh.2022.905458"],"URL":"https:\/\/doi.org\/10.3389\/fpubh.2022.905458","relation":{},"ISSN":["2296-2565"],"issn-type":[{"value":"2296-2565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,3]]},"article-number":"905458"}}