{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:56:07Z","timestamp":1792446967232,"version":"4.5.0"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of diabetes and the strongest initiating risk factor for diabetic foot ulceration. Early diagnosis of DPN through screening measures is, therefore, of great importance for diabetic patients. Recently, shear wave elastography (SWE) has been used as a method that is complementary to neuroelectrophysiological examination in the diagnosis of DPN. We aimed to conduct a meta-analysis based on currently available data to evaluate the performance of tibial nerve stiffness on SWE for diagnosing DPN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Both PubMed, EMBASE, the Cochrane Library, and Web of Science were searched for studies that investigated the diagnostic performance of SWE for DPN up to March 1th, 2022. Three measures of diagnostic test performance, including the summary area under receiver operating characteristics curve (AUROC), the summary sensitivity and specificity, and the summary diagnostic odds ratios were used to assess the diagnostic accuracy of SWE. All included studies were published between 2017 and 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Six eligible studies (with 170 DPN patients, 28 clinically defined DPN patients, 168 non-DPN patients, and 154 control participants) that evaluated tibial nerve stiffness were included for meta-analysis. The summary sensitivity and specificity of SWE for tibial nerve stiffness were 75% (95% confidence interval [CI]: 68\u201380%) and 86% (95% CI: 80\u201390%), respectively, and the summary AUROC was 0.84 (95% CI: 0.81\u20130.87), for diagnosing DPN. A subgroup analysis of five two-dimensional SWE studies revealed similar diagnostic performance, showing the summary sensitivity and specificity of 77% (95% CI: 69\u201383%) and 86% (95% CI: 79\u201391%), respectively, and a summary AUROC value of 0.86 (95% CI: 0.83\u20130.89).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SWE is found to have good diagnostic accuracy for detecting DPN and has considerable potential as an important and noninvasive adjunctive tool in the management of patients with DPN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2022.915883","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T06:54:35Z","timestamp":1658472875000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["Shear wave elastography as a quantitative biomarker of diabetic peripheral neuropathy: A systematic review and meta-analysis"],"prefix":"10.3389","volume":"10","author":[{"given":"Bingtian","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guorong","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaocen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"13686","DOI":"10.1038\/s41598-021-93062-6","article-title":"Bidirectional association between periodontal disease and diabetes mellitus: a systematic review and meta-analysis of cohort studies","volume":"11","author":"Stohr","year":"2021","journal-title":"Sci Rep."},{"key":"B2","unstructured":"IDF Diabetes Atlas2019"},{"key":"B3","doi-asserted-by":"publisher","first-page":"671257","DOI":"10.3389\/fendo.2021.671257","article-title":"Advances in screening, early diagnosis and accurate staging of diabetic neuropathy","volume":"12","author":"Carmichael","year":"2021","journal-title":"Front Endocrinol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1007\/s11892-019-1212-8","article-title":"Epidemiology of peripheral neuropathy and lower extremity disease in diabetes","volume":"19","author":"Hicks","year":"2019","journal-title":"Curr Diab Rep."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.3969\/j.issn.1007-9572.2012.15.001","article-title":"New advances in the diagnosis and treatment of diabetic peripheral neuropathy","volume":"15","author":"Wang","year":"2012","journal-title":"Chin Gen Pract."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.3760\/cma.j.issn.0254-6450.2019.12.014","article-title":"Prevalence and risk factors of diabetic peripheral neuropathy in Chinese communities","volume":"40","author":"Qin","year":"2019","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi."},{"key":"B7","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/S2213-8587(19)30081-6","article-title":"Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention","volume":"7","author":"Selvarajah","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1053\/j.jfas.2016.01.012","article-title":"Mortality after nontraumatic major amputation among patients with diabetes and peripheral vascular disease: a systematic review","volume":"55","author":"Thorud","year":"2016","journal-title":"J Foot Ankle Surg."},{"key":"B9","doi-asserted-by":"publisher","first-page":"719356","DOI":"10.3389\/fendo.2021.719356","article-title":"Gold Standard for Diagnosis of DPN","volume":"12","author":"Yu","year":"2021","journal-title":"Front Endocrinol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.jvs.2009.05.017","article-title":"The Semmes Weinstein monofilament examination as a screening tool for diabetic peripheral neuropathy","volume":"50","author":"Feng","year":"2009","journal-title":"J Vasc Surg."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1001\/jamaneurol.2015.2347","article-title":"The importance of rare subtypes in diagnosis and treatment of peripheral neuropathy: a review","volume":"72","author":"Callaghan","year":"2015","journal-title":"JAMA Neurol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"273","DOI":"10.21037\/qims.2019.02.05","article-title":"Shear wave elastography evaluation of the median and tibial nerve in diabetic peripheral neuropathy","volume":"9","author":"He","year":"2019","journal-title":"Quant Imaging Med Surg."},{"key":"B13","doi-asserted-by":"publisher","first-page":"e1478","DOI":"10.1016\/j.cgh.2021.08.021","article-title":"Diagnostic accuracy of two-dimensional shear wave elastography for liver fibrosis: a multicenter prospective study","volume":"20","author":"Kakegawa","year":"2021","journal-title":"Clin Gastroenterol Hepatol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1002\/hep.29179","article-title":"Assessment of biopsy-proven liver fibrosis by two-dimensional shear wave elastography: an individual patient data-based meta-analysis","volume":"67","author":"Herrmann","year":"2018","journal-title":"Hepatology."},{"key":"B15","doi-asserted-by":"publisher","first-page":"850","DOI":"10.3904\/kjim.2016.326","article-title":"Utility of shear wave elastography to detect papillary thyroid carcinoma in thyroid nodules: efficacy of the standard deviation elasticity","volume":"34","author":"Kim","year":"2019","journal-title":"Korean J Intern Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"221","DOI":"10.3233\/THC-191895","article-title":"The effectiveness of shear wave elastography in the diagnosis of PTMC","volume":"28","author":"Shang","year":"2020","journal-title":"Technol Health Care."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1177\/0284185120961422","article-title":"A qualitative and quantitative assessment of simultaneous strain, shear wave, and point shear wave elastography to distinguish malignant and benign breast lesions","volume":"62","author":"Altintas","year":"2021","journal-title":"Acta Radiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.crad.2020.10.016","article-title":"Virtual touch imaging quantification shear-wave elastography for breast lesions: the diagnostic value of qualitative and quantitative features","volume":"76","author":"Luo","year":"2021","journal-title":"Clin Radiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1148\/rg.2017160116","article-title":"Shear-wave elastography: basic physics and musculoskeletal applications","volume":"37","author":"Taljanovic","year":"2017","journal-title":"Radiographics."},{"key":"B20","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1148\/radiol.2016160135","article-title":"Evaluation of the tibial nerve with shear-wave elastography: a potential sonographic method for the diagnosis of diabetic peripheral neuropathy","volume":"282","author":"Dikici","year":"2017","journal-title":"Radiology."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1007\/s00330-018-5858-4","article-title":"Diagnostic performance of two-dimensional shear wave elastography for evaluating tibial nerve stiffness in patients with diabetic peripheral neuropathy","volume":"29","author":"Jiang","year":"2019","journal-title":"Eur Radiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1002\/jum.15198","article-title":"Feasibility of point shear wave elastography for evaluating diabetic peripheral neuropathy","volume":"39","author":"Wei","year":"2020","journal-title":"J Ultrasound Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"108965","DOI":"10.1016\/j.ejrad.2020.108965","article-title":"Application value of conventional ultrasound and real-time shear wave elastography in patients with type 2 diabetic polyneuropathy","volume":"126","author":"Chen","year":"2020","journal-title":"Eur J Radiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ."},{"key":"B25","doi-asserted-by":"publisher","first-page":"529","DOI":"10.7326\/0003-4819-155-8-201110180-00009","article-title":"QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies","volume":"155","author":"Whiting","year":"2011","journal-title":"Ann Intern Med."},{"key":"B26","year":"2020"},{"key":"B27","doi-asserted-by":"publisher","first-page":"e27104","DOI":"10.1097\/MD.0000000000027104","article-title":"Value of shear wave elastography combined with the Toronto clinical scoring system in diagnosis of diabetic peripheral neuropathy","volume":"100","author":"Wang","year":"2021","journal-title":"Medicine."},{"key":"B28","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s00415-006-0261-5","article-title":"Subclinical diabetic neuropathy with normal conventional electrophysiological study","volume":"254","author":"Bae","year":"2007","journal-title":"J Neurol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1002\/mus.26624","article-title":"Ultrasound elastography for the evaluation of peripheral nerves: a systematic review","volume":"60","author":"Wee","year":"2019","journal-title":"Muscle Nerve."},{"key":"B30","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0168-8227(01)00278-9","article-title":"Evaluation of three screening tests and a risk assessment model for diagnosing peripheral neuropathy in the diabetes clinic","volume":"54","author":"Olaleye","year":"2001","journal-title":"Diabetes Res Clin Pract."},{"key":"B31","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.ejrad.2018.09.027","article-title":"The effectiveness of ultrasonography and ultrasonographic elastography in the diagnosis of carpal tunnel syndrome and evaluation of treatment response after steroid injection","volume":"108","author":"Asadov","year":"2018","journal-title":"Eur J Radiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s12876-019-0976-2","article-title":"Diagnostic effect of shear wave elastography imaging for differentiation of malignant liver lesions: a meta-analysis","volume":"19","author":"Hu","year":"2019","journal-title":"BMC Gastroenterol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"22248","DOI":"10.1038\/s41598-020-79215-z","article-title":"Application of the novel estimation method by shear wave elastography using vibrator to human skeletal muscle","volume":"10","author":"Tsuchida","year":"2020","journal-title":"Sci Rep."},{"key":"B34","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1002\/mus.25245","article-title":"Posture-induced changes in peripheral nerve stiffness measured by ultrasound shear-wave elastography","volume":"55","author":"Greening","year":"2017","journal-title":"Muscle Nerve."}],"container-title":["Frontiers in Public Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2022.915883\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T06:54:42Z","timestamp":1658472882000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2022.915883\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,22]]},"references-count":34,"alternative-id":["10.3389\/fpubh.2022.915883"],"URL":"https:\/\/doi.org\/10.3389\/fpubh.2022.915883","relation":{},"ISSN":["2296-2565"],"issn-type":[{"value":"2296-2565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,22]]},"article-number":"915883"}}