{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T13:26:10Z","timestamp":1788009970324,"version":"build-2784847793"},"reference-count":88,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T00:00:00Z","timestamp":1654214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Diabetes mellitus (DM) have become seriously threatens to human health and life quality worldwide. As a systemic metabolic disease, multiple studies have revealed that DM is related to metabolic bone diseases and always induces higher risk of fracture. In view of this, the links between bone metabolism (BM) and DM (BMDM) have gained much attention and numerous related papers have been published. Nevertheless, no prior studies have yet been performed to analyze the field of BMDM research through bibliometric approach. To fill this knowledge gap, we performed a comprehensive bibliometric analysis of the global scientific publications in this field.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Articles and reviews regarding BMDM published between 2000 and 2021 were obtained from the Web of Science after manually screening. VOSviewer 1.6.16, CiteSpace V 5.8.R3, Bibliometrix, and two online analysis platforms were used to conduct the bibliometric and visualization analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 2,525 documents including 2,255 articles and 270 reviews were retrieved. Our analysis demonstrated a steady increasing trend in the number of publications over the past 22 years (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.989). The United States has occupied the leading position with the largest outputs and highest H-index. University of California San Francisco contributed the most publications, and Schwartz AV was the most influential author. Collaboration among institutions from different countries was relatively few. The journals that published the most BMDM-related papers were <jats:italic>Bone<\/jats:italic> and <jats:italic>Osteoporosis International<\/jats:italic>. Osteoporosis and related fractures are the main bone metabolic diseases of greatest concern in this field. According to co-cited references result, \u201chigh glucose environment,\u201d \u201cglycation end-product\u201d and \u201csodium-glucose co-transporter\u201d have been recognized as the current research focus in this domain. The keywords co-occurrence analysis indicated that \u201cdiabetic osteoporosis,\u201d \u201costeoarthritis,\u201d \u201cfracture risk,\u201d \u201cmeta-analysis,\u201d \u201costeogenic differentiation,\u201d \u201cbone regeneration,\u201d \u201costeogenesis,\u201d and \u201ctrabecular bone score\u201d might remain the research hotspots and frontiers in the near future.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>As a cross-discipline research field, the links between bone metabolism and diabetes mellitus are attracting increased attention. Osteoporosis and related fractures are the main bone metabolic diseases of greatest concern in this field. These insights may be helpful for clinicians to recognize diabetic osteopenia and provide more attention and support to such patients.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2022.918483","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T09:38:50Z","timestamp":1654249130000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":84,"title":["Mapping Knowledge Landscapes and Emerging Trends of the Links Between Bone Metabolism and Diabetes Mellitus: A Bibliometric Analysis From 2000 to 2021"],"prefix":"10.3389","volume":"10","author":[{"given":"Kunming","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaijie","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e442","DOI":"10.1371\/journal.pmed.0030442","article-title":"Projections of global mortality and burden of disease from 2002 to 2030","volume":"3","author":"Mathers","year":"2006","journal-title":"PLoS Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/S2213-8587(21)00347-8","article-title":"Bone fragility in diabetes: novel concepts and clinical implications","volume":"10","author":"Hofbauer","year":"2022","journal-title":"Lancet Diabetes Endocrinol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"116220","DOI":"10.1016\/j.bone.2021.116220","article-title":"Differential risk of fracture attributable to type 2 diabetes mellitus according to skeletal site","volume":"154","author":"Schousboe","year":"2022","journal-title":"Bone."},{"key":"B4","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s00198-006-0253-4","article-title":"Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes\u2013a meta-analysis","volume":"18","author":"Vestergaard","year":"2007","journal-title":"Osteoporos Int."},{"key":"B5","doi-asserted-by":"publisher","first-page":"137","DOI":"10.2337\/dc19-0925","article-title":"Vertebral fractures in individuals with type 2 diabetes: more than skeletal complications alone","volume":"43","author":"Koromani","year":"2020","journal-title":"Diabetes Care."},{"key":"B6","doi-asserted-by":"publisher","first-page":"115457","DOI":"10.1016\/j.bone.2020.115457","article-title":"The risk of hip and non-vertebral fractures in type 1 and type 2 diabetes: a systematic review and meta-analysis update","volume":"137","author":"Vilaca","year":"2020","journal-title":"Bone."},{"key":"B7","doi-asserted-by":"publisher","first-page":"111378","DOI":"10.1016\/j.exger.2021.111378","article-title":"Risk of non-vertebral fractures in men with type 2 diabetes: a systematic review and meta-analysis of cohort studies","volume":"150","author":"Gao","year":"2021","journal-title":"Exp Gerontol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"984","DOI":"10.2174\/1573399816666200324152517","article-title":"Diabetes mellitus and osteoporosis correlation: challenges and hopes","volume":"16","author":"Ala","year":"2020","journal-title":"Curr Diabetes Rev."},{"key":"B9","doi-asserted-by":"publisher","first-page":"808345","DOI":"10.3389\/fmed.2021.808345","article-title":"Editorial: osteoporosis in rheumatic diseases, what's new?","author":"Ruaro","year":"2021","journal-title":"Front Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1111\/1753-0407.12962","article-title":"Management of fracture risk in patients with diabetes-Chinese expert consensus","volume":"11","author":"Liu","year":"2019","journal-title":"J Diabetes."},{"key":"B11","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s40200-016-0275-1","article-title":"Mechanisms involved in altered bone metabolism in diabetes: a narrative review","volume":"15","author":"Ghodsi","year":"2016","journal-title":"J Diabetes Metab Disord."},{"key":"B12","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.lfs.2018.04.042","article-title":"Irbesartan attenuates advanced glycation end products-mediated damage in diabetes-associated osteoporosis through the AGEs\/RAGE pathway","volume":"205","author":"Cheng","year":"2018","journal-title":"Life Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.1210\/js.2019-00160","article-title":"Advanced glycation end products (AGEs), receptor for AGEs, diabetes, and bone: review of the literature","volume":"3","author":"Asadipooya","year":"2019","journal-title":"J Endocr Soc."},{"key":"B14","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1503\/cmaj.080486","article-title":"Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis","volume":"180","author":"Loke","year":"2009","journal-title":"CMA J"},{"key":"B15","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.diabres.2016.04.029","article-title":"DPP-4 inhibitor therapy and bone fractures in people with type 2 diabetes - a systematic review and meta-analysis","volume":"116","author":"Mamza","year":"2016","journal-title":"Diabetes Res Clin Pract."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1111\/dom.12742","article-title":"Lack of evidence for a harmful effect of sodium-glucose co-transporter 2 (SGLT2) inhibitors on fracture risk among type 2 diabetes patients: a network and cumulative meta-analysis of randomized controlled trials","volume":"18","author":"Tang","year":"2016","journal-title":"Diabetes Obes Metab."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1007\/s00198-019-04948-1","article-title":"Metformin use and risk of fracture: a systematic review and meta-analysis of observational studies","volume":"30","author":"Salari-Moghaddam","year":"2019","journal-title":"Osteoporos Int."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1089\/scd.2021.0181","article-title":"Metformin rescues the impaired osteogenesis differentiation ability of rat adipose-derived stem cells in high glucose by activating autophagy","volume":"30","author":"Zhang","year":"2021","journal-title":"Stem Cells Dev."},{"key":"B19","doi-asserted-by":"publisher","first-page":"767591","DOI":"10.3389\/fpubh.2022.767591","article-title":"Bibliometric analysis of renal fibrosis in diabetic kidney disease from 1985 to 2020","volume":"10","author":"Zhang","year":"2022","journal-title":"Front Public Health."},{"key":"B20","doi-asserted-by":"publisher","first-page":"112414","DOI":"10.1016\/j.jep.2019.112414","article-title":"The ethnopharmacological literature: an analysis of the scientific landscape","volume":"250","author":"Yeung","year":"2020","journal-title":"J Ethnopharmacol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/j.outlook.2021.02.006","article-title":"Meta approaches in knowledge synthesis in nursing: a bibliometric analysis","volume":"69","author":"Kokol","year":"2021","journal-title":"Nurs Outlook."},{"key":"B22","doi-asserted-by":"publisher","first-page":"843735","DOI":"10.3389\/fonc.2022.843735","article-title":"The global research of artificial intelligence on prostate cancer: a 22-year bibliometric analysis","volume":"12","author":"Shen","year":"2022","journal-title":"Front Oncol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"787228","DOI":"10.3389\/fmed.2021.787228","article-title":"Mapping knowledge structure and themes trends of osteoporosis in rheumatoid arthritis: a bibliometric analysis","volume":"8","author":"Wu","year":"2021","journal-title":"Front Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s11192-009-0146-3","article-title":"Software survey: VOS viewer, a computer program for bibliometric mapping","volume":"84","author":"van-Eck","year":"2010","journal-title":"Scientometrics."},{"key":"B25","first-page":"724","article-title":"CiteSpace II: visualization and knowledge discovery in bibliographic databases","volume":"2005","author":"Synnestvedt","year":"2005","journal-title":"AMIA Annu Symp Proc."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1514282","DOI":"10.1155\/2020\/1514282","article-title":"Scientometric evaluation of research productivity on diabetes from the Kingdom of Saudi Arabia over the last two decades (2000-2019)","volume":"2020","author":"Gazzaz","year":"2020","journal-title":"J Diabetes Res."},{"key":"B27","doi-asserted-by":"publisher","first-page":"2914","DOI":"10.1016\/j.sjbs.2021.02.025","article-title":"Trends in diabetes research outputs in South Africa over 30 years from 2010 to 2019: a bibliometric analysis","volume":"28","author":"Okaiyeto","year":"2021","journal-title":"Saudi J Biol Sci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"318","DOI":"10.3390\/ijerph18010318","article-title":"Mapping the scientific landscape of diabetes research in Malaysia (2000-2018): a systematic scientometrics study","volume":"18","author":"Ganasegeran","year":"2021","journal-title":"Int J Environ Res Public Health."},{"key":"B29","doi-asserted-by":"publisher","first-page":"7991031","DOI":"10.1155\/2022\/7991031","article-title":"Worldwide research trends on diabetic foot ulcers (2004-2020): suggestions for researchers","volume":"2022","author":"Deng","year":"2022","journal-title":"J Diabetes Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1186\/s12882-021-02369-z","article-title":"The evolution and future of diabetic kidney disease research: a bibliometric analysis","volume":"22","author":"Wei","year":"2021","journal-title":"BMC Nephrol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1136\/bjophthalmol-2020-316609","article-title":"100 most-cited articles on diabetic retinopathy","volume":"105","author":"Koh","year":"2021","journal-title":"Br J Ophthalmol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1007\/s11657-021-01016-2","article-title":"Bibliometric analysis of global research trends on male osteoporosis: a neglected field deserves more attention","volume":"16","author":"Wu","year":"2021","journal-title":"Arch Osteoporos."},{"key":"B33","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s11657-021-00929-2","article-title":"Worldwide research tendency and hotspots on hip fracture: a 20-year bibliometric analysis","volume":"16","author":"Wu","year":"2021","journal-title":"Arch Osteoporos."},{"key":"B34","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1186\/s13018-022-03068-7","article-title":"Knowledge structure and emerging trends on osteonecrosis of the femoral head: a bibliometric and visualized study","volume":"17","author":"Wu","year":"2022","journal-title":"J Orthop Surg Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1186\/s12891-019-2804-9","article-title":"The global state of research in nonsurgical treatment of knee osteoarthritis: a bibliometric and visualized study","volume":"20","author":"Wang","year":"2019","journal-title":"BMC Muscul Disord."},{"key":"B36","doi-asserted-by":"publisher","first-page":"143","DOI":"10.3389\/fnmol.2019.00143","article-title":"Monoamine oxidases (MAOs) as privileged molecular targets in neuroscience: research literature analysis","volume":"12","author":"Yeung","year":"2019","journal-title":"Front Mol Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"587526","DOI":"10.3389\/fphar.2020.587526","article-title":"Open innovation in medical and pharmaceutical research: a literature landscape analysis","volume":"11","author":"Yeung","year":"2021","journal-title":"Front Pharmacol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"753923","DOI":"10.3389\/fendo.2021.753923","article-title":"Research hot spots and trends on melatonin from 2000 to 2019","volume":"12","author":"Meng","year":"2021","journal-title":"Front Endocrinol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1093\/aje\/kwm106","article-title":"Systematic review of type 1 and type 2 diabetes mellitus and risk of fracture","volume":"166","author":"Janghorbani","year":"2007","journal-title":"Am J Epidemiol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"5266","DOI":"10.1073\/pnas.0711119105","article-title":"Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice","volume":"105","author":"Ferron","year":"2008","journal-title":"Proc Natl Acad Sci U S A."},{"key":"B41","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1210\/jcem.86.1.7139","article-title":"Older women with diabetes have an increased risk of fracture: a prospective study","volume":"86","author":"Schwartz","year":"2001","journal-title":"J Clin Endocrinol Metab."},{"key":"B42","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s00198-009-1066-z","article-title":"Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus","volume":"21","author":"Saito","year":"2010","journal-title":"Osteoporos Int."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.2337\/diacare.24.7.1192","article-title":"Type 1 and type 2 diabetes and incident hip fractures in postmenopausal women","volume":"24","author":"Nicodemus","year":"2001","journal-title":"Diabetes Care."},{"key":"B44","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1038\/nrendo.2016.153","article-title":"Mechanisms of diabetes mellitus-induced bone fragility","volume":"13","author":"Napoli","year":"2017","journal-title":"Nat Rev Endocrinol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"845","DOI":"10.2337\/dc07-2270","article-title":"Rosiglitazone-associated fractures in type 2 diabetes: an Analysis from A Diabetes Outcome Progression Trial (ADOPT)","volume":"31","author":"Kahn","year":"2008","journal-title":"Diabetes Care."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1007\/s00125-005-1786-3","article-title":"Relative fracture risk in patients with diabetes mellitus, and the impact of insulin and oral antidiabetic medication on relative fracture risk","volume":"48","author":"Vestergaard","year":"2005","journal-title":"Diabetologia."},{"key":"B47","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.1001\/jama.2011.715","article-title":"Association of BMD and FRAX score with risk of fracture in older adults with type 2 diabetes","volume":"305","author":"Schwartz","year":"2011","journal-title":"JAMA."},{"key":"B48","doi-asserted-by":"publisher","first-page":"e18212","DOI":"10.2196\/18212","article-title":"Theme trends and knowledge structure on mobile health apps: bibliometric analysis","volume":"8","author":"Peng","year":"2020","journal-title":"JMIR Mhealth Uhealth."},{"key":"B49","doi-asserted-by":"publisher","first-page":"3606","DOI":"10.2174\/1381612821666150710145753","article-title":"Antidiabetic drugs: mechanisms of action and potential outcomes on cellular metabolism","volume":"21","author":"Meneses","year":"2015","journal-title":"Curr Pharm Des."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.3390\/ijerph17061982","article-title":"Modeling the research landscapes of artificial intelligence applications in diabetes (GAPRESEARCH)","volume":"17","author":"Vu","year":"2020","journal-title":"Int J Environ Res Public Health."},{"key":"B51","doi-asserted-by":"publisher","first-page":"817620","DOI":"10.3389\/fendo.2022.817620","article-title":"Insights into genome-wide association study for diabetes: a bibliometric and visual analysis from 2001 to 2021","volume":"13","author":"Liu","year":"2022","journal-title":"Front Endocrinol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"300060519879591","DOI":"10.1177\/0300060519879591","article-title":"Comparison of FRAX in postmenopausal Asian women with and without type 2 diabetes mellitus: a retrospective observational study","volume":"48","author":"Wang","year":"2020","journal-title":"J Int Med Res."},{"key":"B53","doi-asserted-by":"publisher","first-page":"832977","DOI":"10.3389\/fendo.2022.832977","article-title":"Prevalent morphometrically assessed vertebral fractures in individuals with type 2 diabetes, prediabetes and normal glucose metabolism: the maastricht study","volume":"13","author":"Van Hulten","year":"2022","journal-title":"Front Endocrinol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1080\/21645515.2017.1420445","article-title":"Trends involving monoclonal antibody (mAb) research and commercialization: a scientometric analysis of IMS lifecycle R&D focus database (1980-2016)","volume":"14","author":"Lai","year":"2018","journal-title":"Hum Vaccin Immunother."},{"key":"B55","doi-asserted-by":"publisher","first-page":"259","DOI":"10.3389\/fimmu.2020.00259","article-title":"Bibliometric analysis of dendritic epidermal T Cell (DETC) research from 1983 to 2019","volume":"11","author":"Deng","year":"2020","journal-title":"Front Immunol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"165","DOI":"10.2147\/DDDT.S335024","article-title":"Chrysin attenuates high glucose-induced BMSC dysfunction via the activation of the PI3K\/AKT\/Nrf2 signaling pathway","volume":"16","author":"Li","year":"2022","journal-title":"Drug Des Devel Ther."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1159\/000479605","article-title":"Alpha-lipoic acid alleviates high-glucose suppressed osteogenic differentiation of MC3T3-E1 cells via antioxidant effect and PI3K\/Akt signaling pathway","volume":"42","author":"Dong","year":"2017","journal-title":"Cell Physiol Biochem."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.3390\/cells8121616","article-title":"Effect of high glucose-induced oxidative stress on paraoxonase 2 expression and activity in caco-2 cells","volume":"8","author":"Morresi","year":"2019","journal-title":"Cells."},{"key":"B59","doi-asserted-by":"publisher","first-page":"670076","DOI":"10.3389\/fphar.2021.670076","article-title":"Coordinated contribution of NADPH oxidase- and mitochondria-derived reactive oxygen species in metabolic syndrome and its implication in renal dysfunction","volume":"12","author":"Lee","year":"2021","journal-title":"Front Pharmacol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1093\/rb\/rbz030","article-title":"Inhibition of the negative effect of high glucose on osteogenic differentiation of bone marrow stromal cells by silicon ions from calcium silicate bioceramics","volume":"7","author":"Dong","year":"2020","journal-title":"Regen Biomater."},{"key":"B61","doi-asserted-by":"publisher","first-page":"735824","DOI":"10.3389\/fendo.2021.735824","article-title":"Effects of anti-diabetic drugs on fracture risk: a systematic review and network meta-analysis","volume":"12","author":"Zhang","year":"2021","journal-title":"Front Endocrinol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1084\/jem.20051947","article-title":"Regulation of osteoclast function and bone mass by RAGE","volume":"203","author":"Zhou","year":"2006","journal-title":"J Exp Med."},{"key":"B63","doi-asserted-by":"publisher","first-page":"e12834","DOI":"10.1111\/cpr.12834","article-title":"Advanced glycation end products inhibit the osteogenic differentiation potential of adipose-derived stem cells by modulating Wnt\/\u03b2-catenin signalling pathway via DNA methylation","volume":"53","author":"Li","year":"2020","journal-title":"Cell Prolif."},{"key":"B64","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1007\/s00223-017-0243-x","article-title":"Advanced glycation end product 3 (AGE3) increases apoptosis and the expression of sclerostin by stimulating TGF-\u03b2 expression and secretion in osteocyte-like MLO-Y4-A2 cells","volume":"100","author":"Notsu","year":"2017","journal-title":"Calcif Tissue Int."},{"key":"B65","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1359\/jbmr.1997.12.3.439","article-title":"Advanced glycation endproducts stimulate interleukin-6 production by human bone-derived cells","volume":"12","author":"Takagi","year":"1997","journal-title":"J Bone Miner Res."},{"key":"B66","doi-asserted-by":"publisher","first-page":"3255","DOI":"10.3892\/mmr.2020.11422","article-title":"Inhibitor of RAGE and glucose-induced inflammation in bone marrow mesenchymal stem cells: effect and mechanism of action","volume":"22","author":"Jiang","year":"2020","journal-title":"Mol Med Rep."},{"key":"B67","doi-asserted-by":"publisher","first-page":"6904","DOI":"10.3390\/ijms22136904","article-title":"Molecular characteristics of RAGE and advances in small-molecule inhibitors","volume":"22","author":"Kim","year":"2021","journal-title":"Int J Mol Sci."},{"key":"B68","doi-asserted-by":"publisher","first-page":"k119","DOI":"10.1136\/bmj.k119","article-title":"Cardiovascular outcomes associated with canagliflozin versus other non-gliflozin antidiabetic drugs: population based cohort study","volume":"360","author":"Patorno","year":"2018","journal-title":"BMJ."},{"key":"B69","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1056\/NEJMoa1611925","article-title":"Canagliflozin and cardiovascular and renal events in type 2 diabetes","volume":"377","author":"Neal","year":"2017","journal-title":"N Engl J Med."},{"key":"B70","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/S2213-8587(14)70227-X","article-title":"Possible adverse effects of SGLT2 inhibitors on bone","volume":"3","author":"Taylor","year":"2015","journal-title":"Lancet Diabetes Endocrinol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1002\/dmrr.2903","article-title":"Sodium-glucose cotransporter 2 (SGLT2) inhibitors and fracture risk in patients with type 2 diabetes mellitus: a meta-analysis","volume":"33","author":"Ruanpeng","year":"2017","journal-title":"Diabetes Metab Res Rev."},{"key":"B72","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1111\/dom.13176","article-title":"Initiation of dapagliflozin and treatment-emergent fractures","volume":"20","author":"Toulis","year":"2018","journal-title":"Diabetes Obes Metab."},{"key":"B73","doi-asserted-by":"publisher","first-page":"700","DOI":"10.3389\/fendo.2019.00700","article-title":"Dapagliflozin attenuates hyperglycemia related osteoporosis in ZDF rats by alleviating hypercalciuria","volume":"10","author":"Wang","year":"2019","journal-title":"Front Endocrinol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1359\/JBMR.040311","article-title":"Diabetes is associated independently of body composition with BMD and bone volume in older white and black men and women: the health, aging, and body composition study","volume":"19","author":"Strotmeyer","year":"2004","journal-title":"J Bone Miner Res."},{"key":"B75","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.jpeds.2003.10.066","article-title":"Alterations in bone characteristics associated with glycemic control in adolescents with type 1 diabetes mellitus","volume":"144","author":"Heap","year":"2004","journal-title":"J Pediatr."},{"key":"B76","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1002\/dmrr.449","article-title":"Skeletal involvement in patients with diabetes mellitus","volume":"20","author":"Carnevale","year":"2004","journal-title":"Diabetes Metab Res Rev."},{"key":"B77","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1210\/en.2003-0746","article-title":"Bone is a target for the antidiabetic compound rosiglitazone","volume":"145","author":"Rzonca","year":"2004","journal-title":"Endocrinology."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1963","DOI":"10.1007\/s00125-004-1560-y","article-title":"Type 2 diabetes mellitus is associated with increased axial bone density in men and women from the hertfordshire cohort study: evidence for an indirect effect of insulin resistance?","volume":"47","author":"Dennison","year":"2004","journal-title":"Diabetologia."},{"key":"B79","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.1002\/jbmr.2573","article-title":"Bone geometry, volumetric density, microarchitecture, and estimated bone strength assessed by HR-pQCT in adult patients with type 1 diabetes mellitus","volume":"30","author":"Shanbhogue","year":"2015","journal-title":"J Bone Miner Res."},{"key":"B80","doi-asserted-by":"publisher","first-page":"2508","DOI":"10.3390\/ijerph19052508","article-title":"A bibliometric analysis of the literature on norovirus disease from 1991-2021","volume":"19","author":"Ogunsakin","year":"2022","journal-title":"Int J Environ Res Public Health."},{"key":"B81","doi-asserted-by":"publisher","first-page":"115451","DOI":"10.1016\/j.bone.2020.115451","article-title":"Trabecular bone score and transilial bone trabecular histomorphometry in type 1 diabetes and healthy controls","volume":"137","author":"Thangavelu","year":"2020","journal-title":"Bone."},{"key":"B82","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1007\/s00198-021-05934-2","article-title":"Influence of glycemic control and hypoglycemia on the risk of fracture in patients with diabetes mellitus: a systematic review and meta-analysis of observational studies","volume":"32","author":"Hidayat","year":"2021","journal-title":"Osteoporos Int."},{"key":"B83","doi-asserted-by":"publisher","first-page":"107990","DOI":"10.1016\/j.diabres.2019.107990","article-title":"Sulfonylurea and fracture risk in patients with type 2 diabetes mellitus: a meta-analysis","volume":"159","author":"Zhang","year":"2020","journal-title":"Diabetes Res Clin Pract."},{"key":"B84","first-page":"3900","article-title":"Research on the correlation of diabetes mellitus complicated with osteoporosis with lipid metabolism, adipokines and inflammatory factors and its regression analysis","volume":"21","author":"Chen","year":"2017","journal-title":"Eur Rev Med Pharmacol Sci."},{"key":"B85","doi-asserted-by":"publisher","first-page":"3043","DOI":"10.1007\/s00198-017-4148-3","article-title":"Parathyroid hormone (1-34) promotes fracture healing in ovariectomized rats with type 2 diabetes mellitus","volume":"28","author":"Liu","year":"2017","journal-title":"Osteoporos Int."},{"key":"B86","doi-asserted-by":"publisher","first-page":"4450","DOI":"10.1002\/jcb.29662","article-title":"Teneligliptin inhibits IL-1\u03b2-induced degradation of extracellular matrix in human chondrocytes","volume":"121","author":"Gao","year":"2020","journal-title":"J Cell Biochem."},{"key":"B87","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.molimm.2021.09.009","article-title":"Trelagliptin ameliorates IL-1\u03b2-impaired chondrocyte function via the AMPK\/SOX-9 pathway","volume":"140","author":"Liu","year":"2021","journal-title":"Mol Immunol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1111\/os.13000","article-title":"Proline-Serine-threonine phosphatase-interacting protein 2 alleviates diabetes mellitus-osteoarthritis in rats through attenuating synovial inflammation and cartilage injury","volume":"13","author":"Li","year":"2021","journal-title":"Orthop Surg."}],"container-title":["Frontiers in Public Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2022.918483\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T09:39:00Z","timestamp":1654249140000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2022.918483\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,3]]},"references-count":88,"alternative-id":["10.3389\/fpubh.2022.918483"],"URL":"https:\/\/doi.org\/10.3389\/fpubh.2022.918483","relation":{},"ISSN":["2296-2565"],"issn-type":[{"value":"2296-2565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,3]]},"article-number":"918483"}}