{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:28:47Z","timestamp":1753892927649,"version":"3.41.2"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T00:00:00Z","timestamp":1655683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore the utility of the scoring system for screening and early warning of cervical cancer based on big data analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 420 women undergoing physical examination in Shenyang from January 2021 to January 2022 were screened by convenient sampling as the study subjects. All females accepted the human papilloma virus (HPV) tests and thin-prep cytology test (TCT), a Rating Questionnaire for Screening and Early Warning of Cervical Cancer was developed, and a warning threshold was derived according to the scores of the questionnaire and the goodness of fit for the results of HPV+TCT tests. The patients were graded according to the threshold, and corresponding intervention strategies for patients of different grades were developed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 420 people undergoing physical examination, 92 (21.90%) obtained scores \u22658 points, and 328 (78.10%) obtained scores &amp;lt; 8 points; in diagnosing cervical cancer, the Rating Questionnaire for Screening and Early Warning of Cervical Cancer had an AUC value of 0.848, specificity of 97.22%, and sensitivity of 86.46%; after scientific intervention, HPV test results showed a significant decrease in both high-risk positive cases and low-risk positive cases (<jats:italic>p<\/jats:italic> &amp;lt; 0.05), and TCT results showed that there was a significant difference in the number of patients with CIN I before and after intervention (<jats:italic>p<\/jats:italic> &amp;lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The scoring system for screening and early warning of cervical cancer based on big data analysis presents certain clinical value in the clinical screening of cervical cancer, which can further improve the screening coverage, is of great significance for the diagnosis and treatment of disease, and helps physician implement hierarchical diagnosis and treatment quickly and precisely.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2022.920956","type":"journal-article","created":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T05:45:44Z","timestamp":1655703944000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Utility of Scoring System for Screening and Early Warning of Cervical Cancer Based on Big Data Analysis"],"prefix":"10.3389","volume":"10","author":[{"given":"Dan","family":"Hou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binjie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangdan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"74","DOI":"10.11152\/mu-2646","article-title":"Elastography of the uterine cervix in gynecology: normal appearance, cervical intraepithelial neoplasia and cancer. A systematic review","volume":"23","author":"Dudea-Simon","year":"2021","journal-title":"Med Ultrason."},{"key":"B2","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1002\/ijgo.13465","article-title":"Association of pretreatment SUV of cervix and SCC-antigen with FIGO2018 stage in Stage IIB-IVB squamous cervical cancer and relationship to prognosis","volume":"152","author":"Shou","year":"2021","journal-title":"Int J Gynaecol Obstet."},{"key":"B3","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1080\/07357907.2020.1742349","article-title":"Flow cytometry characterization of pluripotent transmembrane glycoproteins on resident cervix uteri cells in patients screened for cervical cancer","volume":"38","author":"Colacurci","year":"2020","journal-title":"Cancer Invest."},{"key":"B4","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1136\/ijgc-2019-000890","article-title":"Oncologic outcome after completing or abandoning (radical) hysterectomy in patients with cervical cancer and intraoperative detection of lymph node positivity; ABRAX (ABandoning RAd hyst in cerviX cancer)","volume":"30","author":"Dostalek","year":"2020","journal-title":"Int J Gynecol Cancer."},{"key":"B5","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.remnie.2018.07.002","article-title":"Selective biopsy of the sentinel node in cancer of cervix: experience in validation phase","volume":"37","author":"Cea Garc\u00eda","year":"2018","journal-title":"Rev Esp Med Nucl Imagen Mol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1097\/PGP.0000000000000386","article-title":"Clear cell carcinoma of the uterine cervix presented as a submucosal tumor arising in a background of cervical endometriosis","volume":"37","author":"Hashiguchi","year":"2018","journal-title":"Int J Gynecol Pathol."},{"key":"B7","first-page":"S668","article-title":"A study of agreement between visual inspection with acetic acid of cervix and pap smear for cervical cancer screening","volume":"30","author":"Chaman","year":"2018","journal-title":"J Ayub Med Coll Abbottabad."},{"key":"B8","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1186\/s12985-020-01417-8","article-title":"Evaluation of the SureX HPV genotyping test for the detection of high-risk HPV in cervical cancer screening","volume":"17","author":"Wei","year":"2020","journal-title":"Virol J."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1001\/jama.2013.281053","article-title":"World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects","volume":"310","year":"2013","journal-title":"JAMA"},{"key":"B10","doi-asserted-by":"publisher","first-page":"3114","DOI":"10.1002\/ijc.32695","article-title":"Risk of CIN2 or more severe lesions after negative HPV-mRNA E6\/E7 overexpression assay and after negative HPV-DNA test: Concurrent cohorts with a 5-year follow-up","volume":"146","author":"Zorzi","year":"2020","journal-title":"Int J Cancer."},{"key":"B11","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1158\/1055-9965.EPI-20-1177","article-title":"Assessing 10-Year Safety of a Single Negative HPV Test for Cervical Cancer Screening: Evidence from FOCAL-DECADE Cohort","volume":"30","author":"Gottschlich","year":"2021","journal-title":"Cancer Epidemiol Biomarkers Prev."},{"key":"B12","doi-asserted-by":"publisher","first-page":"112","DOI":"10.4132\/jptm.2019.11.29","article-title":"Comparison of papanicolaou smear and human papillomavirus (HPV) test as cervical screening tools: can we rely on HPV test alone as a screening method? An 11-year retrospective experience at a single institution","volume":"54","author":"Kang","year":"2020","journal-title":"J Pathol Transl Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/s13187-020-01835-w","article-title":"Investigating bangladeshi rural women's awareness and knowledge of cervical cancer and attitude towards HPV vaccination: a community-based cross-sectional analysis","volume":"37","author":"Banik","year":"2022","journal-title":"J Cancer Educ."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.1007\/s10147-020-01727-5","article-title":"Evaluation of the concordance in HPV type between self- and physician-collected samples using a brush-based device and a PCR-based HPV DNA test in Japanese referred patients with abnormal cytology or HPV infection","volume":"25","author":"Onuma","year":"2020","journal-title":"Int J Clin Oncol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s13027-020-0278-x","article-title":"E6\/E7 mRNA test for the detection of high grade cervical intraepithelial neoplasia (CIN2+): a systematic review","volume":"15","author":"Derbie","year":"2020","journal-title":"Infect Agent Cancer."},{"key":"B16","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1080\/08870446.2019.1678749","article-title":"Psychosocial impact of inclusion of HPV test on the management of women with atypical squamous cells of undetermined significance: a study within a randomised pragmatic trial in a middle-income country","volume":"35","author":"Garc\u00e9s-Palacio","year":"2020","journal-title":"Psychol Health."},{"key":"B17","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1111\/jrh.12615","article-title":"Rural-urban differences in HPV testing for cervical cancer screening","volume":"38","author":"Locklar","year":"2022","journal-title":"J Rural Health."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2629","DOI":"10.1002\/ijc.32195","article-title":"Recent increase in incidence of cervical precancerous lesions in Norway: Nationwide study from 1992 to 2016","volume":"145","author":"Orumaa","year":"2019","journal-title":"Int J Cancer."},{"key":"B19","doi-asserted-by":"publisher","first-page":"102040","DOI":"10.1016\/j.jogoh.2020.102040","article-title":"Is the age of cervical cancer diagnosis changing over time?","volume":"50","author":"Gnade","year":"2021","journal-title":"J Gynecol Obstet Hum Reprod."},{"key":"B20","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1007\/s13187-020-01777-3","article-title":"The impact of continuity of care on cervical cancer screening: how visit pattern affects guideline concordance","volume":"37","author":"Li","year":"2022","journal-title":"J Cancer Educ."},{"key":"B21","doi-asserted-by":"publisher","first-page":"840","DOI":"10.3760\/cma.j.issn.0529-567x.2019.12.008","article-title":"Economic evaluation of fifteen cervical cancer screening strategies in rural China","volume":"54","author":"Wang","year":"2019","journal-title":"Zhonghua Fu Chan Ke Za Zhi."},{"key":"B22","doi-asserted-by":"publisher","first-page":"17169","DOI":"10.1074\/jbc.RA120.014048","article-title":"Dysregulation of hsa-miR-34a and hsa-miR-449a leads to overexpression of PACS-1 and loss of DNA damage response (DDR) in cervical cancer","volume":"295","author":"Veena","year":"2020","journal-title":"J Biol Chem."},{"key":"B23","doi-asserted-by":"publisher","first-page":"9725","DOI":"10.1007\/s11033-020-05960-z","article-title":"High-risk HPV infection modulates the promoter hypermethylation of APC, SFRP1, and PTEN in cervical cancer patients of North India","volume":"47","author":"Kadian","year":"2020","journal-title":"Mol Biol Rep."},{"key":"B24","doi-asserted-by":"publisher","first-page":"100102","DOI":"10.1016\/j.jmh.2022.100102","article-title":"What do South Asian immigrant women know about HPV, cervical cancer and its early detection: a cross-sectional Australian study","volume":"5","author":"Alam","year":"2022","journal-title":"J Migr Health."},{"key":"B25","doi-asserted-by":"publisher","first-page":"31","DOI":"10.4103\/ijc.IJC_403_18","article-title":"Cervical intraepithelial neoplasia during pregnancy","volume":"57","author":"Suchonska","year":"2020","journal-title":"Indian J Cancer."}],"container-title":["Frontiers in Public Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2022.920956\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T05:45:47Z","timestamp":1655703947000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2022.920956\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,20]]},"references-count":25,"alternative-id":["10.3389\/fpubh.2022.920956"],"URL":"https:\/\/doi.org\/10.3389\/fpubh.2022.920956","relation":{},"ISSN":["2296-2565"],"issn-type":[{"type":"electronic","value":"2296-2565"}],"subject":[],"published":{"date-parts":[[2022,6,20]]},"article-number":"920956"}}