{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:36:59Z","timestamp":1790181419916,"version":"4.1.0"},"reference-count":90,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Investigate the anxiety and depression states among dry eye (DE) patients during the COVID-19 outbreak and analyze their influence factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was conducted in a tertiary eye hospital in Tianjin, China from March\u2013April 2021. Four hundred twenty-eight DE patients were tested with the Ocular Surface Disease Index, Short Healthy Anxiety Inventory, Hospital Anxiety and Depression Scale, and Pittsburgh Sleep Quality Index. Descriptive statistics was used to assess the difference between DE with depression or anxiety among different groups. And multiple linear regression was used to explore factors that influence anxiety and depression in DE patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence rates of anxiety and depression among DE patients during COVID-19 were 27.34 and 26.87%, respectively. The proportion with comorbid anxiety and depression was 24.30%. Patients' education level (<jats:italic>t<\/jats:italic> = \u22123.001, <jats:italic>P<\/jats:italic> &amp;lt; 0.05; <jats:italic>t<\/jats:italic> = \u22123.631, <jats:italic>P<\/jats:italic> &amp;lt; 0.05), course of disease (<jats:italic>t<\/jats:italic> = 2.341, <jats:italic>P<\/jats:italic> &amp;lt; 0.05; <jats:italic>t<\/jats:italic> = 2.444, <jats:italic>P<\/jats:italic> &amp;lt; 0.05), health anxiety (<jats:italic>t<\/jats:italic> = 3.015, <jats:italic>P<\/jats:italic> &amp;lt; 0.05; <jats:italic>t<\/jats:italic> = 2.731, <jats:italic>P<\/jats:italic> &amp;lt; 0.05), and subjective sleep quality (<jats:italic>t<\/jats:italic> = 3.610, <jats:italic>P<\/jats:italic> &amp;lt; 0.05; <jats:italic>t<\/jats:italic> = 4.203, <jats:italic>P<\/jats:italic> &amp;lt; 0.05) had certain influences on anxiety and depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results showed that subjective symptoms of DE patients were related to depression and anxiety. Higher education, shorter disease duration, lower health anxiety levels, and better subjective sleep quality were associated with the reduced depressive and anxiety symptoms in DE patients. These findings could be deemed beneficial to the treatment and prevention of DE during the COVID-19 epidemic.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2022.929909","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T09:06:21Z","timestamp":1659085581000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Anxiety and depression in dry eye patients during the COVID-19 pandemic: Mental state investigation and influencing factor 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