{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T17:21:24Z","timestamp":1773595284086,"version":"3.50.1"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"Objectives<\/jats:title>Worldwide, around 18.2% of cervical cancer occurred in China, mainly because of lower screening coverage and screening quality in regional disparities. To assess self-sampling for human papillomavirus (HPV) testing, combined with the internet, as a primary cervical cancer screening (CCS) method in low-resource settings, and to establish an internet-based self-sampling CCS-management model.<\/jats:p><\/jats:sec>Methods<\/jats:title>The women who participated registered on a CCS website. We recruited 20,136 women, aged 30\u201359 years, from 13 provinces in China, to perform vaginal self-sampling for HPV testing as a primary CCS, based on the internet. A questionnaire was subsequently used to investigate the acceptability of self-sampling.<\/jats:p><\/jats:sec>Results<\/jats:title>Of the 20,103 women with qualified samples, 35.80% lived in remote areas, 37.69% had never undergone CCS, 59.96% were under-screened, and the overall prevalence of a high-risk of HPV was 13.86%. Of 8,136 respondents, 95.97% of women felt that self-sampling was easy to perform, 84.61% had no discomfort when using a self-sampling brush, 62.37% women were more likely to choose self-sampling for CCS in future, and 92.53% were willing to introduce the concept to others around them. The reliability and ease of self-sampling were independent factors influencing selection of self-sampling (p<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The Internet-facilitated self-sampling for HPV testing and management model for cervical cancer prevention is feasible and effective. It can be used as a supplement to the conventional screening, particularly in outlying areas with few medical resources, to improve the coverage of CCS.<\/jats:p><\/jats:sec>Clinical trial registration<\/jats:title>https:\/\/www.chictr.org.cn<\/jats:ext-link>, identifier: ChiCTR2000032331.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2022.938272","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T14:22:03Z","timestamp":1667830923000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Effectiveness and feasibility of self-sampling for human papillomavirus testing for internet-based cervical cancer 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