{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:29:58Z","timestamp":1792013398704,"version":"4.4.0"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study was to assess the status and trends of antiviral treatment in outpatients with herpes zoster in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prescription data on antiviral drugs were extracted from the database of the Hospital Prescription Analysis Program of China according to the inclusion criteria. Yearly prescriptions and costs were calculated, and trends were analyzed. The trends were further stratified by age, sex, and specific drug use. The distribution of defined daily costs (DDCs) of valaciclovir and famciclovir were analyzed, and trends in the median DDCs were identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 132,911 prescriptions from 49 hospitals located in six major areas of China were included in the analysis. The yearly prescriptions containing antivirals increased from 8,819 in 2010 to 16,361 in 2019. The percentage of prescriptions for patients aged 65 years and above also increased (27.7% in 2010 to 31.0% in 2019), and the number of prescriptions for females was higher than those for males (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001). The average cost of antivirals per prescription decreased; thus, the yearly cost showed no increasing trend. The main prescribed antivirals were valaciclovir and famciclovir, which progressively increased in prescriptions. The use of acyclovir decreased during the study period. Prescriptions containing topical formulations, acyclovir and penciclovir, both increased. The DDCs of valaciclovir and famciclovir decreased dramatically.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The use of antivirals has increased over the decade, while the cost has not. Antiviral treatments adhere well to recent recommendations, except for the use of topical antivirals. The findings of this study may benefit the healthcare source allocation and management of herpes zoster in China.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2022.942377","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T05:21:16Z","timestamp":1659072076000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Antiviral treatment in outpatients with herps zoster in six major areas of China, 2010\u20132019"],"prefix":"10.3389","volume":"10","author":[{"given":"Zhenwei","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"k5095","DOI":"10.1136\/bmj.k5095","article-title":"Herpes zoster infection","volume":"364","author":"Le","year":"2019","journal-title":"BMJ."},{"key":"B2","doi-asserted-by":"publisher","first-page":"e004833","DOI":"10.1136\/bmjopen-2014-004833","article-title":"Systematic review of incidence and complications of herpes zoster: towards a global perspective","volume":"4","author":"Kawai","year":"2014","journal-title":"BMJ Open."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2632","DOI":"10.1080\/21645515.2018.1489193","article-title":"A retrospective survey on herpes zoster disease burden and characteristics in Beijing, China","volume":"14","author":"Lu","year":"2018","journal-title":"Hum Vaccines Immunother."},{"key":"B4","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s40122-019-0127-z","article-title":"The epidemiology of herpes zoster and postherpetic neuralgia in china: results from a cross-sectional study","volume":"8","author":"Yang","year":"2019","journal-title":"Pain Ther."},{"key":"B5","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1056\/NEJMcp1302674","article-title":"Clinical practice: Herpes zoster","volume":"369","author":"Cohen","year":"2013","journal-title":"N Engl J Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1097\/j.pain.0000000000001718","article-title":"Aggregate health and economic burden of herpes zoster in the United States: illustrative example of a pain condition","volume":"161","author":"Harvey","year":"2020","journal-title":"Pain."},{"key":"B7","doi-asserted-by":"publisher","first-page":"ofz007","DOI":"10.1093\/ofid\/ofz007","article-title":"The economic burden and impact on quality of life of herpes zoster and postherpetic neuralgia in individuals aged 50 years or older in Italy","volume":"6","author":"Matthews","year":"2019","journal-title":"Open Forum Infect Dis."},{"key":"B8","doi-asserted-by":"publisher","first-page":"3325","DOI":"10.1007\/s12325-021-01717-7","article-title":"del R, Garcia-Martinez JA, Matthews S. 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