{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:28:39Z","timestamp":1753892919776,"version":"3.41.2"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Comprehensive studies on the prognosis of solitary bone plasmacytoma (SPB) are lacking, especially in elderly patients with SPB. This study aims to establish a novel nomogram and risk stratification system to predict the overall survival (OS) of elderly patients with SPB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The data of elderly patients with SPB from 2000 to 2017 were identified in the SEER database. SPB patients were randomly assigned to the training set (<jats:italic>n<\/jats:italic> = 825) and validation set (<jats:italic>n<\/jats:italic> = 354). The Cox regression analysis was used to determine the independent risk factors for OS in elderly SPB patients. The nomogram was established and assessed by the area under the receiver operating curve (AUC), the consistency index (C-index), and the calibration plot. Patients were divided into low-, medium-, and high-risk groups based on the score of the nomogram. The Kaplan-Meier (K-M) curve was used to verify the differences in overall survival among the three groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>A total of 1,179 elderly patients with SPB were included in the study. Age at diagnosis, prior cancer before SPB, marital status, radiotherapy, and chemotherapy were independent risk factors of OS. The AUC of the 3, 5, and 8-year OS in the training and validation sets were between 0.707 and 0.860. The C-index and calibration plot also indicated that the nomogram has great predictive accuracy and robustness. After risk stratification, patients in the high-risk group had the worst OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A novel nomogram was built to predict the OS of elderly patients with SPB. It will help clinicians formulate more reasonable and personalized treatment strategies.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2022.954816","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T08:41:38Z","timestamp":1663058498000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["A new prediction model for overall survival of elderly patients with solitary bone plasmacytoma: A population-based study"],"prefix":"10.3389","volume":"10","author":[{"given":"Yingying","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiemin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaomei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaozhu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyi","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1038\/s41375-018-0099-8","article-title":"Treatment approaches and outcomes in plasmacytomas: analysis using a national dataset","volume":"32","author":"Goyal","year":"2018","journal-title":"Leukemia."},{"key":"B2","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1111\/j.1365-2141.2008.07421.x","article-title":"Plasmacytoma of bone, extramedullary plasmacytoma, and multiple myeloma: incidence and survival in the United States, 1992-2004","volume":"144","author":"Dores","year":"2009","journal-title":"Br J Haematol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s13045-017-0549-1","article-title":"Diagnosis, treatment, and response assessment in solitary plasmacytoma: updated recommendations from a European Expert Panel","volume":"11","author":"Caers","year":"2018","journal-title":"J Hematol Oncol."},{"key":"B4","article-title":"Solitary plasmacytoma: population-based analysis of survival trends and effect of various treatment modalities in the USA","volume-title":"BMC Cancer","author":"Thumallapally","year":"2017"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e2017052","DOI":"10.4084\/mjhid.2017.052","article-title":"Solitary plasmacytoma","volume":"9","author":"Grammatico","year":"2017","journal-title":"Mediterr J Hematol Infect Dis."},{"key":"B6","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/1471-2407-6-118","article-title":"Prognostic factors in solitary plasmacytoma of the bone: a multicenter Rare Cancer Network study","volume":"6","author":"Knobel","year":"2006","journal-title":"BMC Cancer"},{"key":"B7","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1016\/S0140-6736(14)60493-1","article-title":"Multiple myeloma","volume":"385","author":"R\u00f6llig","year":"2015","journal-title":"Lancet (London, England)."},{"key":"B8","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.spinee.2019.09.018","article-title":"Reossification and prognosis following radiotherapy with\/without surgery for spinal solitary plasmacytoma of the bone: a retrospective study of 39 patients","volume":"20","author":"Ouyang","year":"2020","journal-title":"Spine."},{"key":"B9","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1002\/cam4.3533","article-title":"Survival trends and prognostic factors in patients with solitary plasmacytoma of bone: a population-based study","volume":"10","author":"Shen","year":"2021","journal-title":"Cancer Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"895765","DOI":"10.1100\/2012\/895765","article-title":"A review for solitary plasmacytoma of bone and extramedullary plasmacytoma","volume":"2012","author":"Kilciksiz","year":"2012","journal-title":"ScientificWorld J."},{"key":"B11","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1002\/hon.2415","article-title":"Holte H. 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