{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:26:03Z","timestamp":1792592763921,"version":"4.5.0"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>According to the World health organization, neonatal mortality is defined as the death of babies within the first 28 days of their lives. The newborn period is the most vulnerable period for a child's survival, with the bulk of neonatal deaths occurring on the first day and week. According to a recent study, about a third of all newborn deaths occur within the first day of life, and nearly three-quarters occur within the first week. This study aimed to assess the determinants of neonatal mortality among neonates admitted to the neonatal intensive care unit in Dessie comprehensive and specialized hospital, northeast Ethiopia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Health institution-based unmatched case-control study was conducted among neonates admitted to Dessie comprehensive and specialized hospital, Ethiopia from February 01 up to March 30, 2020. After keeping cases and controls in separate frames, study participants were chosen using a simple random sampling procedure until the sample size was met. Epi data version 7.0 and SPSS version 25 were used for data entry and analysis respectively. <jats:italic>P<\/jats:italic> \u2264 0.05 was used as a cut point of statistical significance in multivariable binary logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 698 (233 cases and 465 controls) participated in the study. Pregnancy induced hypertension (AOR = 3.02; 95% CI; 1.47\u20136.17), public hospital delivery (AOR = 3.44; 95% CI; 1.84\u20136.42), prematurity (AOR = 2.06; 95% CI; 1.43\u20132.96), being referred (AOR = 4.71; 95% CI; 3.01\u20137.39), and hypothermia (AOR = 2.44; 95% CI; 1.56\u20133.82) were determinant factors of neonatal mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pregnancy-induced hypertension, public hospital delivery, prematurity, referral, and hypothermia were found to be the determinant factors of neonatal mortality. It would be important to give due attention to neonates delivered from mothers with a history of hypertensive disorder. Besides better to give due attention to neonates delivered in public health institutions, prematurely delivered, referred, and hypothermic neonates. Lastly, further research should be conducted to investigate the additional determinants of neonatal mortality.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2022.979402","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T06:08:17Z","timestamp":1664258897000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Determinants of neonatal mortality among neonates admitted to neonatal intensive care unit of Dessie comprehensive and specialized hospital, Northeast Ethiopia; An unmatched case-control study"],"prefix":"10.3389","volume":"10","author":[{"given":"Getu Engida","family":"Wake","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalkidan","family":"Chernet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almaz","family":"Aklilu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fentahun","family":"Yenealem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girma","family":"Wogie Fitie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Amera Tizazu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohannes Moges","family":"Mittiku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moges","family":"Sisay Chekole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geremew Kindie","family":"Behulu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,27]]},"reference":[{"key":"B1","first-page":"433","year":"2006","journal-title":"Neonatal and Perinatal Mortality,Country, Regional and Global Estimates"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e20160551","DOI":"10.1542\/peds.2016-0551","article-title":"Standard terminology for fetal, infant, and perinatal deaths","volume":"137","author":"Barfield","year":"2016","journal-title":"Pediatrics."},{"key":"B3","unstructured":"48Un IgmeLevels & Trends in Child Mortality Report.2020"},{"key":"B4","first-page":"144","volume-title":"Making Every Baby Count: Audit and Review of Stillbirths and Neonatal Deaths","year":"2016"},{"key":"B5","first-page":"1","article-title":"Levels & Trends in Child Mortality: Estimates: Report","author":"UN","year":"2018"},{"key":"B6","unstructured":"Every newborn: An action plan to end Preventable deathsWho, Unicef582014"},{"key":"B7","first-page":"1","article-title":"Maternal and Newborn Health in Southern","author":"Region","year":"2020"},{"key":"B8","first-page":"115","year":"2016"},{"key":"B9","unstructured":"Ethiopia Mini Demographic and Health Survey 2019: Final Report12072019"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e0201125","DOI":"10.1371\/journal.pone.0201125","article-title":"Neonatal and under-five mortality rate in Indian districts with reference to Sustainable Development Goal 3: an analysis of the National Family Health Survey of India (NFHS), 2015\u20132016","volume":"13","author":"Bora","year":"2018","journal-title":"PLoS ONE."},{"key":"B11","first-page":"1","year":"2019","journal-title":"World Heal Organization"},{"key":"B12","unstructured":"20152018Milestones Country Progress, Plans and Moving ForwardReaching the Every Newborn National.2017"},{"key":"B13","unstructured":"149Delivering the Millennium Development Goals to Reduce Maternal and Child Mortality: A Sytematic Review of Impact Evaluation Evidence.2012"},{"key":"B14","unstructured":"40United Nations Inter-gr Child Mortal EstimLevels and Trends in Child Mortality: Report.2017"},{"key":"B15","unstructured":"Neonatal intensi (NICU) Training Management Protocolve care unit8\n            SavaDI\n          OT Pract.132014"},{"key":"B16","first-page":"28","year":"2015","journal-title":"Success Factors for Women's and Children's Health Ethiopia"},{"key":"B17","first-page":"124","year":"2015","journal-title":"World Health Statics. 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