{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T10:52:13Z","timestamp":1793357533408,"version":"4.5.0"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T00:00:00Z","timestamp":1680739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The triglyceride-glucose (TyG)-driven indices, incorporating obesity indices, have been proposed as reliable markers of insulin resistance and related comorbidities such as diabetes. This study evaluated the effectiveness of these indices in detecting prediabetes in normal-weight individuals from a Middle Eastern population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the data of 5,996 adult Qatari participants from the Qatar Biobank cohort, we employed adjusted logistic regression to assess the ability of various obesity and triglyceride-related indices to detect prediabetes in normal-weight (18.5\u2009\u2264\u2009BMI &amp;lt;25\u2009kg\/m<jats:sup>2<\/jats:sup>) adults (\u226518\u2009years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the normal-weight adults, 13.62% had prediabetes. TyG-waist-to-height ratio (TyG-WHTR) was significantly associated with prediabetes among normal-weight men [OR per 1-SD 2.68; 95% CI (1.67\u20134.32)] and women [OR per 1-SD 2.82; 95% CI (1.61\u20134.94)]. Compared with other indices, TyG-WHTR had the highest area under the curve (AUC) value for prediabetes in men [AUC: 0.76, 95% CI (0.70\u20130.81)] and women [AUC: 0.73, 95% CI (0.66\u20130.80)], and performed significantly higher than other indices (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05) in detecting prediabetes in men. Tyg-WHTR shared similar diagnostic values as fasting plasma glucose (FPG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our findings suggest that the TyG-WHTR index could be a better indicator of prediabetes for general clinical usage in normal weight Qatari adult men than other obesity and TyG-related indices. TyG-WHTR can help identify a person\u2019s risk for developing prediabetes in both men and women when combined with FPG results.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2023.1086771","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T04:42:46Z","timestamp":1680756166000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":32,"title":["The triglyceride glucose-waist-to-height ratio outperforms obesity and other triglyceride-related parameters in detecting prediabetes in normal-weight Qatari adults: A cross-sectional study"],"prefix":"10.3389","volume":"11","author":[{"given":"Neyla S.","family":"Al Akl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias N.","family":"Haoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halima","family":"Bensmail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelilah","family":"Arredouani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,4,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"631","DOI":"10.5604\/12321966.1226858.","article-title":"Prevalence of metabolic syndrome in normal weight individuals","volume":"23","author":"Suliga","year":"2016","journal-title":"Ann Agric Environ Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2141","DOI":"10.1038\/s41366-021-00858-7","article-title":"Normal weight obesity and unaddressed cardiometabolic health risk-a narrative review","volume":"45","author":"Wijayatunga","year":"2021","journal-title":"Int J Obes"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1093\/eurheartj\/ehp487","article-title":"Normal weight obesity: A risk factor for cardiometabolic dysregulation and cardiovascular mortality","volume":"31","author":"Romero-Corral","year":"2010","journal-title":"Eur Heart J"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.3390\/nu12041106","article-title":"Normal-weight obesity is associated with increased cardiometabolic risk in young adults","volume":"12","author":"Correa-Rodr\u00edguez","year":"2020","journal-title":"Nutrients"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1093\/nutrit\/nuw019","article-title":"Normal-weight obesity syndrome: Diagnosis, prevalence, and clinical implications","volume":"74","author":"Franco","year":"2016","journal-title":"Nutr Rev"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.2337\/dc18-S002","article-title":"2. 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