{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:27:56Z","timestamp":1787027276698,"version":"build-2736575974"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T00:00:00Z","timestamp":1679011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to evaluate the intervention effect of concurrent training on children with malignant tumors to provide evidence for prescribing exercise for children with malignant tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twelve databases were searched from inception to October 15, 2022. Two researchers independently screened the literature, evaluated the quality, extracted the data, and performed the meta-analysis using R.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      A total of nine randomized controlled trials involving 371 children were included in this study. The meta-analysis revealed that muscle strength was significantly greater in the exercise group compared to the usual care group [SMD = 0.26, 95% CI (0.04, 0.48),\n                      <jats:italic>P<\/jats:italic>\n                      = 0.023], with subgroup analysis showing no significant difference in upper limb [SMD = 0.13, 95% CI (\u22120.17, 0.43),\n                      <jats:italic>P<\/jats:italic>\n                      = 0.318] and a considerable difference in lower limb strength [SMD = 0.41, 95% CI (0.08, 0.74),\n                      <jats:italic>P<\/jats:italic>\n                      = 0.015]. Physical activity [SMD = 0.57, 95% CI (0.03, 1.1),\n                      <jats:italic>P<\/jats:italic>\n                      = 0.038], timed up and down stairs test [SMD = \u22121.22, 95% CI (\u22122.04, \u22120.4),\n                      <jats:italic>P<\/jats:italic>\n                      = 0.004], 6-min walking ability [SMD = 0.75, 95% CI (0.38, 1.11),\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.01], quality of life [SMD = 0.28, 95% CI (0.02, 0.53),\n                      <jats:italic>P<\/jats:italic>\n                      = 0.033], and cancer-related fatigue [SMD = \u22120.53, 95% CI (\u22120.86, \u22120.19),\n                      <jats:italic>P<\/jats:italic>\n                      = 0.002] were significantly better than the usual care group. There were no significant differences in peak oxygen uptake [SMD = 0.13, 95% CI (\u22120.18, 0.44),\n                      <jats:italic>P<\/jats:italic>\n                      = 0.397], depression [SMD = 0.06, 95% CI (\u22120.38, 0.5),\n                      <jats:italic>P<\/jats:italic>\n                      = 0.791], and withdrawal rates [RR = 0.59, 95% CI (0.21, 1.63),\n                      <jats:italic>P<\/jats:italic>\n                      = 0.308] between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Concurrent training could improve physical performance for children with malignancy but had no significant effect on mental health. Because the quality level of evidence is mostly very low, future high-quality randomized controlled trials are required to confirm these findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic review registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/www.crd.york.ac.uk\/PROSPERO\/display_record.php?RecordID=364140<\/jats:ext-link>\n                      , identifier CRD42022308176.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2023.1127255","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T00:55:49Z","timestamp":1679014549000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Effect of concurrent training on physical performance and quality of life in children with malignancy: A systematic review and 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