{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T13:50:40Z","timestamp":1779889840700,"version":"3.53.1"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>There are few studies on the prevalence and factors associated with frailty and pre-frailty in older adults with asthma worldwide. The aim of this study was to examine the epidemiological status and factors associated with frailty and pre-frailty in older adults with asthma in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Research design and methods<\/jats:title><jats:p>Data were obtained from the Sample Survey of Aged Population in Urban and Rural China in 2015, a nationwide cross-sectional survey covering 224,142 older people aged 60 years or older in 31 provinces\/autonomous regions\/municipalities in mainland China. We performed frailty and pre-frailty assessments using the frailty index, and the diagnosis of asthma in the older adults was self-reported based on the history of the physician's diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine thousand four hundred sixteen older adults with asthma were included in the study. The age-sex standardized prevalence of frailty and pre-frailty in Chinese older adults with asthma was 35.8% (95% CI 34.8%\u221236.7%) and 54.5% (95% CI 53.5%\u221255.5%). Multinomial logistic regression analysis showed that increased age, female, illiteracy, living alone, poor economic status, ADL disability, comorbid chronic diseases, previous hospitalization in the past year, and residence in northern China were associated with frailty and pre-frailty in older adults with asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of frailty and pre-frailty in Chinese older adults with asthma is very high, and assessment of frailty should become routine in the management of older adults with asthma. Appropriate public health prevention strategies based on identified risk factors for frailty in older adults with asthma should be developed to reduce the burden of frailty in Chinese older adults with asthma.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2023.1136135","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T17:53:05Z","timestamp":1677865985000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Epidemiological status and associated factors of frailty and pre-frailty in older adults with asthma in China: A national cross-sectional study"],"prefix":"10.3389","volume":"11","author":[{"given":"Xue-zhai","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-bing","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-bin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di-shan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu-xia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-ping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,3]]},"reference":[{"key":"B1","first-page":"1","article-title":"National surveillance of asthma: United States, 2001-2010","volume":"35","author":"Moorman","year":"2012","journal-title":"Vital Health Stat"},{"key":"B2","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.rmed.2018.02.010","article-title":"Prevalence and risk factors of asthma in mainland China: the CARE study","volume":"137","author":"Lin","year":"2018","journal-title":"Respir Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/S0140-6736(19)31147-X","article-title":"Prevalence, risk factors, and management of asthma in China: a national cross-sectional study","volume":"394","author":"Huang","year":"2019","journal-title":"Lancet."},{"key":"B4","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/S2213-2600(20)30105-3","article-title":"Prevalence and attributable health burden of chronic respiratory diseases, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"8","author":"Collaborators","year":"2020","journal-title":"Lancet Respir Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.1513\/AnnalsATS.201608-658ST","article-title":"An Official American Thoracic Society Workshop Report: evaluation and management of asthma in the elderly","volume":"13","author":"Skloot","year":"2016","journal-title":"Ann Am Thorac Soc."},{"key":"B6","doi-asserted-by":"publisher","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146","article-title":"Frailty in older adults: evidence for a phenotype","volume":"56","author":"Fried","year":"2001","journal-title":"J Gerontol A Biol Sci Med Sci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.mad.2019.04.005","article-title":"Age-related deficit accumulation and the diseases of ageing","volume":"180","author":"Rockwood","year":"2019","journal-title":"Mech Ageing Dev."},{"key":"B8","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/S0140-6736(12)62167-9","article-title":"Frailty in elderly people","volume":"381","author":"Clegg","year":"2013","journal-title":"Lancet."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1111\/j.1532-5415.2012.04054.x","article-title":"Prevalence of frailty in community-dwelling older persons: a systematic review","volume":"60","author":"Collard","year":"2012","journal-title":"J Am Geriatr Soc."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1016\/S0140-6736(19)31786-6","article-title":"Frailty: implications for clinical practice and public health","volume":"394","author":"Hoogendijk","year":"2019","journal-title":"Lancet."},{"key":"B11","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.jamda.2020.03.008","article-title":"The association between frailty and healthcare expenditure among Chinese older adults","volume":"21","author":"Jin","year":"2020","journal-title":"J Am Med Dir Assoc."},{"key":"B12","doi-asserted-by":"publisher","first-page":"996190","DOI":"10.3389\/fpubh.2022.996190","article-title":"A study on the prevalence and related factors of frailty and pre-frailty in the older population with diabetes in China: a national cross-sectional study","volume":"10","author":"Zeng","year":"2022","journal-title":"Front Public Health"},{"key":"B13","volume-title":"Survey Report on the Living Conditions of China's Urban and Rural Older Persons.","author":"Dang","year":"2018"},{"key":"B14","doi-asserted-by":"publisher","first-page":"979015","DOI":"10.3389\/fcvm.2022.979015","article-title":"Self-reported prevalence and potential factors influencing cardio-cerebral vascular disease among the Chinese elderly: a national cross-sectional study","volume":"9","author":"Meng","year":"2022","journal-title":"Front Cardiovasc Med."},{"key":"B15","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/1471-2318-8-24","article-title":"A standard procedure for creating a frailty index","volume":"8","author":"Searle","year":"2008","journal-title":"BMC Geriatr."},{"key":"B16","doi-asserted-by":"publisher","first-page":"759","DOI":"10.3109\/02770900903067895","article-title":"Prevalence of asthma among adult females and males in the United States: results from the National Health and Nutrition Examination Survey (NHANES), 2001-2004","volume":"46","author":"McHugh","year":"2009","journal-title":"J Asthma."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2022.10.005","article-title":"Frailty and muscle weakness in elderly patients with asthma and their association with cumulative lifetime oral corticosteroid exposure","author":"Ryu","year":"2022","journal-title":"Allergol Int."},{"key":"B18","doi-asserted-by":"publisher","first-page":"e000526","DOI":"10.1136\/bmjresp-2019-000526","article-title":"Asthma is associated with frailty among community-dwelling adults: the GAZEL cohort","volume":"7","author":"Landre","year":"2020","journal-title":"BMJ Open Respir Res"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7603\/s40681-015-0001-1","article-title":"Emerging roles of frailty and inflammaging in risk assessment of age-related chronic diseases in older adults: the intersection between aging biology and personalized medicine","volume":"5","author":"Wu","year":"2015","journal-title":"Biomedicine."},{"key":"B20","doi-asserted-by":"publisher","first-page":"636","DOI":"10.3760\/cma.j.issn.0578-1426.2019.09.004","article-title":"[Chinese guidelines for the diagnosis and treatment of allergic asthma (2019, the first edition)]","volume":"58","year":"2019","journal-title":"Zhonghua Nei Ke Za Zhi"},{"key":"B21","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1016\/j.jaci.2011.06.048","article-title":"Asthma in the elderly: current understanding and future research needs\u2013a report of a National Institute on Aging (NIA) workshop","volume":"128","author":"Hanania","year":"2011","journal-title":"J Allergy Clin Immunol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.je.2016.09.008","article-title":"Prevalence of frailty in Japan: a systematic review and meta-analysis","volume":"27","author":"Kojima","year":"2017","journal-title":"J Epidemiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.exger.2016.12.021","article-title":"Sex differences in frailty: a systematic review and meta-analysis","volume":"89","author":"Gordon","year":"2017","journal-title":"Exp Gerontol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1093\/ageing\/afz160","article-title":"Linking early life risk factors to frailty in old age: evidence from the China Health and Retirement Longitudinal Study","volume":"49","author":"Li","year":"2020","journal-title":"Age Ageing."},{"key":"B25","doi-asserted-by":"publisher","first-page":"e42","DOI":"10.1016\/S2468-2667(19)30226-9","article-title":"Social inequalities in multimorbidity, frailty, disability, and transitions to mortality: a 24-year follow-up of the Whitehall II cohort study","volume":"5","author":"Dugravot","year":"2020","journal-title":"Lancet Public Health."},{"key":"B26","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s12877-021-02745-2","article-title":"Associations of social isolation, social participation, and loneliness with frailty in older adults in Singapore: a panel data analysis","volume":"22","author":"Ge","year":"2022","journal-title":"BMC Geriatr."},{"key":"B27","doi-asserted-by":"publisher","first-page":"e323","DOI":"10.1016\/S2468-2667(18)30091-4","article-title":"Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493 737 UK Biobank participants","volume":"3","author":"Hanlon","year":"2018","journal-title":"Lancet Public Health."}],"container-title":["Frontiers in Public Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2023.1136135\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T17:53:12Z","timestamp":1677865992000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2023.1136135\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,3]]},"references-count":27,"alternative-id":["10.3389\/fpubh.2023.1136135"],"URL":"https:\/\/doi.org\/10.3389\/fpubh.2023.1136135","relation":{},"ISSN":["2296-2565"],"issn-type":[{"value":"2296-2565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,3]]},"article-number":"1136135"}}