{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T07:08:46Z","timestamp":1793084926756,"version":"4.5.0"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T00:00:00Z","timestamp":1684108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Post-COVID-19 syndrome (PCS) usually occurs 3 months after the onset of COVID-19 with a symptom duration of at least 2 months without an alternative diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to describe the prevalence, characteristics, and impact on the quality of life (QoL) of post-COVID-19 syndrome in patients with a history of hospitalization for COVID-19.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We conducted a cross-sectional study. Patients who required hospitalization due to COVID-19 between March 2020 and October 2021 were invited to answer a PCS questionnaire and the EQ-5D instrument. A total of 246 patients were included: 187 (76%) met the definition of PCS and 54% were men, with a median age of 50 years (IQR 41\u201363).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 187 patients with PCS, the median time to symptom onset after hospital discharge was 1 day (IQR 1\u201320), and the median symptom duration was 150 days (IQR 90\u2013225). A total of 27 different symptoms were reported; the most frequent were difficulty concentrating (81%), dyspnea (75%), arthralgia (71%), fatigue (68%), and hair loss (60%). Some symptoms, such as difficulty concentrating, arthralgia\/myalgia, and hair loss, were more prevalent in women with PCS. Patients with PCS had a higher frequency of tobacco smoking (37 vs. 4%, <jats:italic>p<\/jats:italic> = 0.02) and increased severity of lung involvement in the initial chest tomography (75 vs. 58%, <jats:italic>p<\/jats:italic> = 0.01) than those without PCS. Patients with PCS were less likely to receive antivirals (15.5 vs. 27%, <jats:italic>p<\/jats:italic> = 0.04). No difference between ICU admission, mechanical ventilation, and length of hospital stay was found. Patients with PCS had a lower visual analog scale result for EQ-5D vs. those without (80 [IQR 70\u201390] vs. 89.5 [IQR 75\u201390], <jats:italic>p<\/jats:italic> = 0.05). All five QoL dimensions were affected in PCS patients, showing increased pain\/discomfort (67 vs. 39%, <jats:italic>p<\/jats:italic> = &amp;lt; 0.001), difficulties in performing usual activities (39.2 vs. 20.3%, <jats:italic>p<\/jats:italic> = 0.03), and anxiety\/depression (57.5 vs. 37%, <jats:italic>p<\/jats:italic> = 0.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PCS occurred in 76% of hospitalized patients with prolonged duration and QoL impairment. Neurological symptoms such as difficulty concentrating were the most frequent symptoms. Timely diagnostic and therapeutic interventions are required.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2023.1155951","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T05:01:50Z","timestamp":1684126910000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":31,"title":["Post-COVID-19 syndrome and quality of life impairment in severe COVID-19 Mexican patients"],"prefix":"10.3389","volume":"11","author":[{"given":"Carla Marina","family":"Rom\u00e1n-Montes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yesenia","family":"Flores-Soto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo Arturo","family":"Guaracha-Basa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla Mar\u00eda","family":"Tamez-Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Sifuentes-Osornio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma. 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