{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:38:02Z","timestamp":1790386682811,"version":"4.1.0"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>To characterize the pattern of hospitalization in patients with Alzheimer's disease (AD) or Parkinson's disease (PD), and compare the differences to see whether AD patients and PD patients have a different picture of hospitalization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The clinical features of all consecutive patients from January 2017 to December 2020 were reviewed. We identified AD patients and PD patients from an electronic database in a tertiary medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study group comprised 995 AD patients and 2,298 PD patients who were admitted to the hospital for the first time, and re-hospitalized 231 AD patients and 371 PD patients were also included. AD patients were older than PD patients when they were hospitalized (<jats:italic>p<\/jats:italic> &amp;lt; 0.001). AD patients had longer lengths of stay, higher re-hospitalization rates, and higher intrahospital mortality rates than PD patients during hospitalization even after adjusting age and gender. PD patients had higher levels of total cost than AD patients due to the cost of the deep brain stimulation (DBS) insertion. Hospitalizations for AD patients occurred most often in the department of geriatrics, while most PD patients were admitted to the department of neurology. Hospitalization due to the presence of comorbid conditions was much higher in AD patients, but a larger proportion of PD patients were hospitalized due to PD disease itself.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study found that AD patients and PD patients have a significantly different picture of hospitalization. It is important to implement different management for hospitalized AD and PD, and different emphasis should be given when establishing primary prevention strategies, informing care needs, and guiding healthcare resource planning.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2023.1159110","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T04:33:45Z","timestamp":1683174825000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Analyses of hospitalization in Alzheimer's disease and Parkinson's disease in a tertiary hospital"],"prefix":"10.3389","volume":"11","author":[{"given":"Sihui","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifang","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/S1474-4422(18)30403-4","article-title":"Global, regional, and national burden of Alzheimer's disease and other dementias, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"18","author":"GBD","year":"2019","journal-title":"Lancet Neurol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"e661","DOI":"10.1016\/S2468-2667(20)30185-7","article-title":"Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: a cross-sectional study","volume":"5","author":"Jia","year":"2020","journal-title":"Lancet Public Health."},{"key":"B3","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/S1474-4422(18)30295-3","article-title":"Global, regional, and national burden of Parkinson's disease, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016 [published correction appears in Lancet Neurol","volume":"17","author":"GBD","year":"2018","journal-title":"Lancet Neurol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1212\/01.wnl.0000247740.47667.03","article-title":"Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030","volume":"68","author":"Dorsey","year":"2007","journal-title":"Neurology."},{"key":"B5","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1159\/000171044","article-title":"Reasons for hospital admissions in dementia patients in Birmingham, UK, during 2002-2007","volume":"26","author":"Natalwala","year":"2008","journal-title":"Dement Geriatr Cogn Disord."},{"key":"B6","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1212\/WNL.41.2_Part_1.168","article-title":"Young-onset Parkinson's disease: a clinical review","volume":"41","author":"Golbe","year":"1991","journal-title":"Neurology."},{"key":"B7","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1002\/mds.870130605","article-title":"Young-onset Parkinson's disease revisited \u2013Clinical features, natural history, and mortality","volume":"13","author":"Schrag","year":"1998","journal-title":"Mov Disord."},{"key":"B8","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.parkreldis.2014.01.022","article-title":"Reasons for hospitalization in Parkinson's disease: a case-control study","volume":"20","author":"Braga","year":"2014","journal-title":"Parkinsonism Relat Disord."},{"key":"B9","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1001\/archneur.1997.00550150024011","article-title":"Mortality from Parkinson disease","volume":"54","author":"Louis","year":"1997","journal-title":"Arch Neurol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1136\/jnnp-2014-307822","article-title":"Hospitalisation and comorbidities in Parkinson's disease: a large Australian retrospective study","volume":"86","author":"Lubomski","year":"2015","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"B11","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1002\/mds.23449","article-title":"Clinical problems in the hospitalized Parkinson's disease patient: systematic review","volume":"26","author":"Gerlach","year":"2011","journal-title":"Mov Disord."},{"key":"B12","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1159\/000311032","article-title":"Impact of dementia on hospitalization","volume":"35","author":"Guijarro","year":"2010","journal-title":"Neuroepidemiology."},{"key":"B13","doi-asserted-by":"publisher","first-page":"13039","DOI":"10.1111\/ijcp.13039","article-title":"Factors that lead to hospitalisation in patients with Parkinson disease-a systematic review","volume":"72","author":"Koay","year":"2018","journal-title":"Int J Clin Pract."},{"key":"B14","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1007\/s10654-019-00481-x","article-title":"Hospitalisation of people with dementia: evidence from English electronic health records from 2008 to 2016","volume":"34","author":"Sommerlad","year":"2019","journal-title":"Eur J Epidemiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1111\/j.1532-5415.2010.02924.x","article-title":"Hospitalization in community-dwelling persons with Alzheimer's disease: frequency and causes","volume":"58","author":"Rudolph","year":"2010","journal-title":"J Am Geriatr Soc."},{"key":"B16","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.jalz.2015.06.1892","article-title":"Diagnosis and treatment of dementia in neurology outpatient departments of general hospitals in China","volume":"12","author":"Jia","year":"2016","journal-title":"Alzheimers Dement."},{"key":"B17","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s12916-019-1369-7","article-title":"Hospitalisation rates and predictors in people with dementia: a systematic review and meta-analysis","volume":"17","author":"Shepherd","year":"2019","journal-title":"BMC Med"},{"key":"B18","doi-asserted-by":"publisher","first-page":"e035779","DOI":"10.1136\/bmjopen-2019-035779","article-title":"The association between dementia severity and hospitalisation profile in a newly assessed clinical cohort: the South London and Maudsley case register","volume":"10","author":"Gungabissoon","year":"2020","journal-title":"BMJ Open."},{"key":"B19","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.jamda.2013.01.011","article-title":"Causes of hospital admission for people with dementia: a systematic review and meta-analysis","volume":"14","author":"Toot","year":"2013","journal-title":"J Am Med Dir Assoc."},{"key":"B20","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1097\/01.NAJ.0000308961.99857.33","article-title":"Preventing aspiration in older adults with dysphagia","volume":"108","author":"Palmer","year":"2008","journal-title":"Am J Nurs."},{"key":"B21","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1002\/gps.2722","article-title":"Discharge diagnosis and comorbidity profile in hospitalized older patients with dementia","volume":"27","author":"Zuliani","year":"2012","journal-title":"Int J Geriatr Psychiatry."},{"key":"B22","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.archger.2016.06.008","article-title":"Outcomes of dementia: systematic review and meta-analysis of hospital administrative database studies","volume":"66","author":"Rao","year":"2016","journal-title":"Arch Gerontol Geriatr."},{"key":"B23","doi-asserted-by":"publisher","first-page":"411","DOI":"10.3233\/JPD-212874","article-title":"Rate of hospitalizations and underlying reasons among people with parkinson's disease: population-based cohort study in UK primary care","volume":"12","author":"Okunoye","year":"2022","journal-title":"J Parkinsons Dis."},{"key":"B24","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1111\/j.1445-5994.2006.01123.x","article-title":"Reasons for admission to hospital for Parkinson's disease","volume":"36","author":"Temlett","year":"2006","journal-title":"Intern Med J."},{"key":"B25","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.parkreldis.2016.01.011","article-title":"A systematic review of interventions to reduce hospitalisation in Parkinson's disease","volume":"24","author":"Muzerengi","year":"2016","journal-title":"Parkinsonism Relat Disord."},{"key":"B26","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.parkreldis.2010.11.009","article-title":"Management of the hospitalized patient with Parkinson's disease: current state of the field and need for guidelines","volume":"17","author":"Aminoff","year":"2011","journal-title":"Parkinsonism Relat Disord."},{"key":"B27","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/j.parkreldis.2013.06.006","article-title":"High rates and the risk factors for emergency room visits and hospitalization in Parkinson's disease","volume":"19","author":"Hassan","year":"2013","journal-title":"Parkinsonism Relat Disord."},{"key":"B28","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1111\/j.1600-0404.2009.01239.x","article-title":"Parkinson's disease and hospital admissions: frequencies, diagnoses and costs","volume":"121","author":"Vossius","year":"2010","journal-title":"Acta Neurol Scand."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.2174\/1570159X18666200528142429","article-title":"Recent advancements in pathogenesis, diagnostics and treatment of Alzheimer's disease","volume":"18","author":"Khan","year":"2020","journal-title":"Curr Neuropharmacol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.mcna.2018.10.009","article-title":"The Alzheimer's disease clinical spectrum: diagnosis and management","volume":"103","author":"Atri","year":"2019","journal-title":"Med Clin North Am."},{"key":"B31","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1192\/bjp.bp.112.119354","article-title":"Determinants for undetected dementia and late-life depression","volume":"203","author":"Chen","year":"2013","journal-title":"Br J Psychiatry."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1007\/s10072-020-04253-4","article-title":"Societ\u00e0 Italiana di NeuroGeriatria (SINEG). The role of the neuropsychologist in memory clinics","volume":"41","author":"Salvadori","year":"2020","journal-title":"Neurol Sci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/s10072-004-0232-5","article-title":"Comorbid disorders and hospitalisation in Parkinson's disease: a prospective study","volume":"25","author":"Martignoni","year":"2004","journal-title":"Neurol Sci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1093\/oxfordjournals.aje.a121399","article-title":"Epidemiologic studies of Parkinson's disease. II A hospital-based survey","volume":"95","author":"Kessler","year":"1972","journal-title":"Am J Epidemiol."}],"container-title":["Frontiers in Public Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2023.1159110\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T04:33:49Z","timestamp":1683174829000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2023.1159110\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,4]]},"references-count":34,"alternative-id":["10.3389\/fpubh.2023.1159110"],"URL":"https:\/\/doi.org\/10.3389\/fpubh.2023.1159110","relation":{},"ISSN":["2296-2565"],"issn-type":[{"value":"2296-2565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,4]]},"article-number":"1159110"}}