{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:42:03Z","timestamp":1788910923199,"version":"build-2803163510"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T00:00:00Z","timestamp":1691020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011901","name":"Rajiv Gandhi Science and Technology Commission, Government of Maharashtra","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>India is witnessing an epidemic of type 2 diabetes. Overweight\/obesity, overnutrition, physical inactivity, and family history are well-known risk factors for diabetes. We investigated the role of undernutrition in the development of diabetes among rural adolescent girls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>DERVAN cohort study was set up in the KONKAN region of the western Indian state of Maharashtra. It enrolled 1,520 adolescent girls (16\u201318 years old at the time of enrollment). We measured glycemic parameters (glucose, insulin, and HbA<jats:sub>1<\/jats:sub>C) and body size using anthropometry and body composition using bioimpedance. Prediabetes was diagnosed using the American Diabetic Association (ADA) criteria. We also calculated various HOMA indices for insulin resistance (HOMA-IR), \u03b2-cell function (HOMA-\u03b2), insulin sensitivity (HOMA-S), and compensatory \u03b2-cell response using a homeostasis model. BMI, body fat%, and waist circumferences were treated as exposures and all the glycemic parameters and indices as outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age of the subjects was 16.6 years. The median weight, height, and BMI were 40.7 kg, 151.7 cm, and 17.5 kg\/m<jats:sup>2<\/jats:sup>, respectively. Prevalence of underweight was 28.8%, and stunting was observed in 30.4%. Thinness and obesity using BMI were observed in 58.4% and 4.2%, respectively. The median body fat% was 22.5, and excess body fat (&amp;gt;35%) was observed in 5.7%. The prevalence of prediabetes was 39.4%. Fasting insulin concentrations, HOMA-IR, and HOMA-\u03b2 showed a positive trend across body composition quartiles (<jats:italic>p<\/jats:italic> &amp;lt; 0.001). HOMA-S and compensatory \u03b2-cell response showed an inverse trend (<jats:italic>p<\/jats:italic> &amp;lt; 0.001). Compared with prediabetic girls in the overweight\/obese group, girls most undernourished group had lower median insulin concentrations (8.1 \u03bcIU\/ml vs. 17.1 \u03bcIU\/ml), lower HOMA-IR (1.1 vs. 2.3), and lower HOMA-\u03b2 (75.6 vs. 129.2) but higher sensitivity (87.4 vs. 43.7) (<jats:italic>p<\/jats:italic> &amp;lt; 0.001) for all.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We have reported a high prevalence of prediabetes among rural adolescent girls with a very low prevalence of obesity. Prediabetes in obesity is driven by hyperinsulinemia and overworking of the pancreas while poor \u03b2-cell function and poor insulin secretion are major drivers in the undernourished group. The high-risk diabetes screening programs are much needed for the undernourished populations. Caution should be exercised for planning the interventions as overfeeding (or overnutrition) is likely to put the populations at risk of development of obesity and insulin resistance.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2023.1181401","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T18:11:28Z","timestamp":1691086288000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Prediabetes in rural adolescent girls from DERVAN cohort: data from the KONKAN region of the state of Maharashtra, India 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